Results 11 to 20 of about 4,623 (196)
Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice. [PDF]
PLoS ONE, 2015 TMEM16A/ANO1 is a calcium-activated chloride channel expressed in several types of epithelia and involved in various physiological processes, including proliferation and development.
Devendra Kumar Maurya +7 more
doaj +11 more sources
TMEM16A in Cystic Fibrosis: Activating or Inhibiting? [PDF]
Frontiers in Pharmacology, 2019 The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann +8 more
doaj +7 more sources
Journal of Advanced Research, 2021 Introduction: Ca2+-activated Cl− channel TMEM16A is expressed in endothelial cells, and contributes to many diseases such as hypertension, blood-brain barrier dysfunction, and pulmonary hypertension.
Qinghuan Xiao
exaly +3 more sources
Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis [PDF]
Cell Death and Disease, 2022 Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of liver transplantation. Transmembrane member 16A (TMEM16A), a component of hepatocyte Ca2+-activated chloride channel, has been implicated in a variety of ...
Jiawei Guo +17 more
doaj +2 more sources
The diverse roles of TMEM16A Ca2+-activated Cl− channels in inflammation
Journal of Advanced Research, 2021 Background: Transmembrane protein 16A (TMEM16A) Ca2+-activated Cl− channels have diverse physiological functions, such as epithelial secretion of Cl− and fluid and sensation of pain.
Qinghuan Xiao
exaly +3 more sources
Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells [PDF]
Membranes, 2021 Regulation of the Ca2+-activated Cl− channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent ...
Khaoula Talbi +4 more
doaj +3 more sources
Epithelial Chloride Transport by CFTR Requires TMEM16A [PDF]
Scientific Reports, 2017 AbstractCystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the secretory chloride/bicarbonate channel in airways and intestine that is activated through ATP binding and phosphorylation by protein kinase A, but fails to operate in cystic fibrosis (CF).
Roberta Benedetto +8 more
openaire +6 more sources
Journal of Advanced Research, 2020 TMEM16A Ca2+-activated Cl− channels are expressed in pancreatic acinar cells and participate in inflammation-associated diseases. Whether TMEM16A contributes to the pathogenesis of acute pancreatitis (AP) remains unknown.
Qinghuan Xiao
exaly +3 more sources
The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin
Frontiers in Pharmacology, 2021 The transmembrane 16 (TMEM16) family contains 10 subtypes, and the function of each protein is different. TMEM16A is a calcium-activated chloride channel involved in physiological and pathological situations.
Masataka Sunagawa +2 more
exaly +3 more sources
Control of Ion Transport by Tmem16a Expressed in Murine Intestine [PDF]
Frontiers in Physiology, 2019 Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann +8 more
doaj +3 more sources