Results 31 to 40 of about 3,802 (167)
Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f
Gastro Hep Advances, 2022 Background and Aims: Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn.
Rainer Schreiber +2 more
doaj +1 more source
TMEM16A in gastrointestinal and vascular smooth muscle contractility. [PDF]
J PhysiolAbstractCalcium‐activated Cl− channels (CaCC) are widely expressed proteins which regulate various physiological functions. TMEM16A is a CaCC expressed in the gastrointestinal and cardiovascular systems, where it is a major regulator of tissue contraction.
Tas ST, Anderson MO, Cil O.
europepmc +3 more sources
Electrophysiological Characterization of TMEM16A [PDF]
Biophysical Journal, 2015 Sweating is an essential physiological process to regulate body temperature in humans and various disorders are associated with dysregulated sweat formation.Primary sweat secretion in human eccrine sweat glands is initiated by Ca2+-activated Cl- channels (CaCC).
Bruggemann, Andrea +10 more
openaire +1 more source
The pharmacology of the TMEM16A channel: therapeutic opportunities
Trends in Pharmacological Sciences, 2022 The TMEM16A Ca2+-gated Cl- channel is involved in a variety of vital physiological functions and may be targeted pharmacologically for therapeutic benefit in diseases such as hypertension, stroke, and cystic fibrosis (CF). The determination of the TMEM16A structure and high-throughput screening efforts, alongside ex vivo and in vivo animal studies and ...
Rumaitha Al-Hosni +3 more
openaire +2 more sources
Niclosamide potentiates TMEM16A and induces vasoconstriction
Biophysical Journal, 2023 ABSTRACT The TMEM16A calcium-activated chloride channel is a promising therapeutic target for various diseases. Niclosamide, an anthelmintic medication, has been considered as a TMEM16A inhibitor for treating asthma and chronic obstructive pulmonary disease, but was recently found to possess broad-spectrum off-target effects.
Pengfei Liang +4 more
openaire +3 more sources
The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A [PDF]
Biophysical Journal, 2020 The calcium-activated chloride channel TMEM16A is involved in many physiological processes, and insufficient function of TMEM16A may lead to the occurrence of various diseases. Therefore, TMEM16A activators are supposed to be potentially useful for treatment of TMEM16A downregulation-inducing diseases.
Shuai Guo +7 more
openaire +2 more sources
Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-Activated Cl- channel TMEM16A. [PDF]
PLoS ONE, 2012 The Ca(2+)-activated Cl(-) channel TMEM16A is involved in epithelial fluid secretion, smooth muscle contraction and neurosensory signaling. We identified a Thai herbal antidiarrheal formulation that inhibited TMEM16A Cl(-) conductance. C18-reversed-phase
Zhen Yao +5 more
doaj +1 more source
Arctigenin Attenuates Vascular Inflammation Induced by High Salt through TMEM16A/ESM1/VCAM-1 Pathway
Biomedicines, 2022 Salt-sensitive hypertension is closely related to inflammation, but the mechanism is barely known. Transmembrane member 16A (TMEM16A) is the Ca2+-activated chloride channel in epithelial cells, smooth muscle cells, and sensory neurons.
Mengying Zeng +5 more
doaj +1 more source
Reduced Expression of TMEM16A Impairs Nitric Oxide-Dependent Cl− Transport in Retinal Amacrine Cells
Frontiers in Cellular Neuroscience, 2022 Postsynaptic cytosolic Cl− concentration determines whether GABAergic and glycinergic synapses are inhibitory or excitatory. We have shown that nitric oxide (NO) initiates the release of Cl− from acidic internal stores into the cytosol of retinal ...
Tyler Christopher Rodriguez +3 more
doaj +1 more source
Functional expression of TMEM16A in taste bud cells [PDF]
The Journal of Physiology, 2021 Key points Taste transduction occurs in taste buds in the tongue epithelium. The Ca2+‐activated Cl– channels TMEM16A and TMEM16B play relevant physiological roles in several sensory systems. Here, we report that TMEM16A, but not TMEM16B, is expressed in the apical part of taste buds.
Guarascio D. M. +4 more
openaire +3 more sources