Results 61 to 70 of about 3,827 (168)

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing [PDF]

Journal of Biological Chemistry, 2009
Expression of TMEM16A protein is associated with the activity of Ca(2+)-activated Cl(-) channels. TMEM16A primary transcript undergoes alternative splicing. thus resulting in the generation of multiple isoforms. We have determined the pattern of splicing and assessed the functional properties of the corresponding TMEM16A variants.
Ferrera, Loretta, Caputo, Antonella, Ubby, Ifeoma, Bussani, Erica, Zegarra-Moran, Olga, Ravazzolo, Roberto, Pagani, Franco, Galietta, Luis J. V.   +7 more
openaire   +4 more sources

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville, Ryan F. Yoshimura, Hanh A. Nguyen, Ruiming Zhao, Derk J. Hogenkamp, Steve A. N. Goldstein, Geoffrey W. Abbott   +6 more
wiley   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Intermolecular Interactions in the TMEM16A Dimer Controlling Channel Activity [PDF]

Scientific Reports, 2016
AbstractTMEM16A and TMEM16B are plasma membrane proteins with Ca2+-dependent Cl− channel function. By replacing the carboxy-terminus of TMEM16A with the equivalent region of TMEM16B, we obtained channels with potentiation of channel activity. Progressive shortening of the chimeric region restricted the “activating domain” to a short sequence close to ...
Scudieri, Paolo, Musante, Ilaria, Gianotti, Ambra, Moran, Oscar, Galietta, Luis J. V.   +4 more
openaire   +5 more sources

Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

Frontiers in Physiology, 2019
Calcium-activated anion secretion is expected to ameliorate cystic fibrosis, a genetic disease that carries an anion secretory defect in exocrine tissues.
Génesis Vega, Génesis Vega, Anita Guequén, Malin E. V. Johansson, Liisa Arike, Beatriz Martínez-Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Amber R. Philp, Luis J. Galietta, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores   +15 more
doaj   +1 more source

Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction

FASEB BioAdvances, 2020
The calcium‐activated chloride channel (CaCC) TMEM16A enables chloride secretion across several transporting epithelia, including in the airways. Additional roles for TMEM16A have been proposed, which include regulating mucus production and secretion and
Henry Danahay, Roy Fox, Sarah Lilley, Holly Charlton, Kathryn Adley, Lee Christie, Ejaz Ansari, Camille Ehre, Alexis Flen, Michael J. Tuvim, Burton F. Dickey, Colin Williams, Sarah Beaudoin, Stephen P Collingwood, Martin Gosling   +14 more
doaj   +1 more source

Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells. [PDF]

PLoS ONE, 2014
Metastasis leads to poor prognosis in colorectal cancer patients, and there is a growing need for new therapeutic targets. TMEM16A (ANO1, DOG1 or TAOS2) has recently been identified as a calcium-activated chloride channel (CaCC) and is reported to be ...
Yujie Sui, Meiyan Sun, Fei Wu, Longfei Yang, Weihua Di, Guizhen Zhang, Lili Zhong, Zhiming Ma, Jinhao Zheng, Xuedong Fang, Tonghui Ma   +10 more
doaj   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source