Results 81 to 90 of about 3,827 (168)

TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension [PDF]

British Journal of Pharmacology, 2019
Background and PurposeCoronary artery disease leads to ischaemic heart disease and ultimately myocardial infarction. Thus, it is important to determine the factors that regulate coronary blood flow. Ca2+‐activated chloride channels contribute to the regulation of arterial tone; however, their role in coronary arteries is unknown.
Henry R. Askew Page, Thomas Dalsgaard, Samuel N. Baldwin, Thomas A. Jepps, Oleksandr Povstyan, Søren P. Olesen, Iain A. Greenwood   +6 more
openaire   +5 more sources

Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis

Journal of Experimental Pharmacology, 2021
Madalena C Pinto,1,* Iris AL Silva,1,* Miriam F Figueira,2 Margarida D Amaral,1 Miquéias Lopes-Pacheco1,* 1Biosystems & Integrative Sciences Institute (BioISI), Faculty of Sciences, University of Lisboa, Lisboa, Portugal; 2Marsico Lung ...
Pinto MC, Silva IAL, Figueira MF, Amaral MD, Lopes-Pacheco M   +4 more
doaj  

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, Volume 2, Issue 3, June 2026.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Calcium- and Voltage-Dependent Dual Gating ANO1 is an Intrinsic Determinant of Repolarization in Rod Bipolar Cells of the Mouse Retina

Cells, 2020
TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.
Sun-Sook Paik, Yong Soo Park, In-Beom Kim   +2 more
doaj   +1 more source

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

TMEM92 shields DDX3X from TTC3‐mediated degradation to confer chemoresistance in triple‐negative breast cancer

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
TMEM92 protects DDX3X from degradation by the E3 ligase TTC3, promoting TNBC cell proliferation and tumour growth. Depleting TMEM92 not only suppresses tumour growth but also sensitises cells to cisplatin, suggesting that targeting this axis is a potential therapeutic strategy.
Hao Shen, Xiaochao Jia, Xu Li, Zhi Li, Zhihua Zhang, Yang Zhao, Lei Shen, Xiaoqiu Bu, Qiang Ma, Chunli Liang, Xiaoti Lin, Lin‐Xiaoxi Ma, Chuan Qin   +12 more
wiley   +1 more source

Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin.

PLoS ONE, 2015
Induction of mucus hypersecretion in the airway epithelium by Th2 cytokines is associated with the expression of TMEM16A, a Ca2+-activated Cl- channel. We asked whether exposure of airway epithelial cells to bacterial components, a condition that mimics ...
Emanuela Caci, Paolo Scudieri, Emma Di Carlo, Patrizia Morelli, Silvia Bruno, Ida De Fino, Alessandra Bragonzi, Ambra Gianotti, Elvira Sondo, Loretta Ferrera, Alessandro Palleschi, Luigi Santambrogio, Roberto Ravazzolo, Luis J V Galietta   +13 more
doaj   +1 more source

Endothelial Dysfunction Following Enhanced TMEM16A Activity in Human Pulmonary Arteries

Cells, 2020
Endothelial dysfunction is one of the hallmarks of different vascular diseases, including pulmonary arterial hypertension (PAH). Ion channelome changes have long been connected to vascular remodeling in PAH, yet only recently has the focus shifted ...
Davor Skofic Maurer, Diana Zabini, Chandran Nagaraj, Neha Sharma, Miklós Lengyel, Bence M. Nagy, Saša Frank, Walter Klepetko, Elisabeth Gschwandtner, Péter Enyedi, Grazyna Kwapiszewska, Horst Olschewski, Andrea Olschewski   +12 more
doaj   +1 more source

9‐phenanthrol inhibits TMEM16A channels

The FASEB Journal, 2013
Intravascular pressure stimulates several smooth muscle cell TRP channels, including TRPM4, leading to membrane depolarization and vasoconstriction (the myogenic response). Previous studies using 9‐phenanthrol (9‐phen), a TRPM4 channel inhibitor, suggest that TRPM4 is essential for pressure‐induced depolarization and constriction ...
Sarah Burris, Zachary P. Neeb, Jonathan Jaggar   +2 more
openaire   +1 more source

Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury

Neural Regeneration Research, 2019
Transmembrane member 16A (TMEM16A) is involved in many physiological functions, such as epithelial secretion, sensory conduction, nociception, control of neuronal excitability, and regulation of smooth muscle contraction, and may be important in ...
Qin-Yi Chen, Chao-Yang Tan, Yang Wang, Ke-Tao Ma, Li Li, Jun-Qiang Si   +5 more
doaj   +1 more source