Results 71 to 80 of about 4,623 (196)

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

Extracellular Chloride Regulates TMEM16A Gating [PDF]

Biophysical Journal, 2015
The gating mechanism of TMEM16A, an essential subunit of the Ca2+-activated Cl- channel, remains incompletely understood. Gating of TMEM16A channels is complex because elevation of intracellular calcium concentration ([Ca2+]i), strong depolarizations (Vm), and high extracellular Cl or highly permeant anions seem to contribute.
Contreras-Vite, Juan A., Cruz-Rangel, Silvia, Pérez-Cornejo, Patricia, Hartzell, H. Criss, Arreola, Jorge   +4 more
openaire   +1 more source

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source

Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

Frontiers in Physiology, 2019
Calcium-activated anion secretion is expected to ameliorate cystic fibrosis, a genetic disease that carries an anion secretory defect in exocrine tissues.
Génesis Vega, Génesis Vega, Anita Guequén, Malin E. V. Johansson, Liisa Arike, Beatriz Martínez-Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Amber R. Philp, Luis J. Galietta, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores   +15 more
doaj   +1 more source

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source

Expression of cytokeratin 5 and Ki67 in the olfactory epithelium of TMEM16A^-/- and TMEM16A^+/+ littermate mice.

, 2015
Confocal images of coronal sections of the olfactory epithelium from a region near the transition zone with the respiratory epithelium at P4 from TMEM16A+/+ (A-C) and TMEM16A-/- (D-F) mice. Cell nuclei were stained by DAPI. Scale bars = 10 μm.
Devendra Kumar Maurya (753367), Anna Menini (266689), Nicoletta Pedemonte (383764), Tiago Henriques (753368), Jason R. Rock (247452), Monica Marini (753369), Brian D. Harfe (148989), Luis J. V. Galietta (753370)   +7 more
core   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells. [PDF]

PLoS ONE, 2014
Metastasis leads to poor prognosis in colorectal cancer patients, and there is a growing need for new therapeutic targets. TMEM16A (ANO1, DOG1 or TAOS2) has recently been identified as a calcium-activated chloride channel (CaCC) and is reported to be ...
Yujie Sui, Meiyan Sun, Fei Wu, Longfei Yang, Weihua Di, Guizhen Zhang, Lili Zhong, Zhiming Ma, Jinhao Zheng, Xuedong Fang, Tonghui Ma   +10 more
doaj   +1 more source

Cell densities in the olfactory epithelium of TMEM16A^-/- and TMEM16A^+/+ littermate mice.

, 2015
Comparison among the average number of supporting cells and olfactory sensory neurons in the olfactory epithelium of TMEM16A-/- and TMEM16A+/+ littermate mice.
Devendra Kumar Maurya (753367), Anna Menini (266689), Nicoletta Pedemonte (383764), Tiago Henriques (753368), Jason R. Rock (247452), Monica Marini (753369), Brian D. Harfe (148989), Luis J. V. Galietta (753370)   +7 more
core   +1 more source

Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction

FASEB BioAdvances, 2020
The calcium‐activated chloride channel (CaCC) TMEM16A enables chloride secretion across several transporting epithelia, including in the airways. Additional roles for TMEM16A have been proposed, which include regulating mucus production and secretion and
Henry Danahay, Roy Fox, Sarah Lilley, Holly Charlton, Kathryn Adley, Lee Christie, Ejaz Ansari, Camille Ehre, Alexis Flen, Michael J. Tuvim, Burton F. Dickey, Colin Williams, Sarah Beaudoin, Stephen P Collingwood, Martin Gosling   +14 more
doaj   +1 more source