Results 81 to 90 of about 4,623 (196)

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, Volume 2, Issue 3, June 2026.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Ca2+ Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl– Channels

Frontiers in Cell and Developmental Biology, 2020
All vertebrate cells activate Cl– currents (ICl,swell) when swollen by hypotonic bath solution. The volume-regulated anion channel VRAC has now been identified as LRRC8/SWELL1.
Raquel Centeio, Jiraporn Ousingsawat, Rainer Schreiber, Karl Kunzelmann   +3 more
doaj   +1 more source

CLCA2 and TMEM16A do not directly interact.

, 2018
(A) Immunoblots of cells transfected with CLCA2, TMEM16A, or both. Proteins were immunoprecipitated and detected with antibodies specific for either protein. (B) Cells stably expressing vector or CLCA2 were transiently transfected with TMEM16A (TMEM) and
Aarushi Sharma (5216615), Grace Ramena (2549773), Louis Premkumar (5216612), Yufang Yin (2549770), Randolph C. Elble (502366)   +4 more
core   +1 more source

TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension [PDF]

British Journal of Pharmacology, 2019
Background and PurposeCoronary artery disease leads to ischaemic heart disease and ultimately myocardial infarction. Thus, it is important to determine the factors that regulate coronary blood flow. Ca2+‐activated chloride channels contribute to the regulation of arterial tone; however, their role in coronary arteries is unknown.
Henry R. Askew Page, Thomas Dalsgaard, Samuel N. Baldwin, Thomas A. Jepps, Oleksandr Povstyan, Søren P. Olesen, Iain A. Greenwood   +6 more
openaire   +5 more sources

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

TMEM92 shields DDX3X from TTC3‐mediated degradation to confer chemoresistance in triple‐negative breast cancer

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
TMEM92 protects DDX3X from degradation by the E3 ligase TTC3, promoting TNBC cell proliferation and tumour growth. Depleting TMEM92 not only suppresses tumour growth but also sensitises cells to cisplatin, suggesting that targeting this axis is a potential therapeutic strategy.
Hao Shen, Xiaochao Jia, Xu Li, Zhi Li, Zhihua Zhang, Yang Zhao, Lei Shen, Xiaoqiu Bu, Qiang Ma, Chunli Liang, Xiaoti Lin, Lin‐Xiaoxi Ma, Chuan Qin   +12 more
wiley   +1 more source

Potentiation of TMEM16A Currents by CLCA1 in Cystic Fibrosis Airway

, 2021
In the airway, proper activity of the anion channel cystic fibrosis transmembrane conductance regulator (CFTR) contributes to innate immune defense by maintaining a hydratedand alkaline mucus layer through the conductance of chloride and bicarbonate ions.
Berry, Kayla
core   +2 more sources

The role of TMEM16A (ANO1) and TMEM16F (ANO6) in cell migration [PDF]

Pflügers Archiv - European Journal of Physiology, 2013
Members of the TMEM16 family have recently been described as Ca(2+)-activated Cl(-) channels. They have been implicated in cancer and appear to be associated with poor patient prognosis. Here, we investigate the role of TMEM16 channels in cell migration, which is largely unknown.
Jacobsen, K.S., Zeeberg, K., Sauter, Daniel Rafael Peter, Poulsen, K.A., Hoffmann, Else Kay, Schwab, A.   +5 more
openaire   +4 more sources

Non-canonical translation start sites in the TMEM16A chloride channel

, 2014
TMEM16A is a plasma membrane protein with voltage- and calcium-dependent chloride channel activity. The role of the various TMEM16A domains in expression and function is poorly known.
Caci, Emanuela, Tomati, Valeria, Scudieri, Paolo, Farrugia, Gianrico, Galietta, Luis J. V., Ravazzolo, Roberto, Mazzone, Amelia, Galietta, Luis J.V., Sondo, Elvira   +8 more
core   +1 more source

Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo [PDF]

, 2020
In autosomal dominant polycystic kidney disease (ADPKD) multiple bilateral renal cysts gradually enlarge, leading to a decline in renal function. Transepithelial chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) and ...
Rainer Schreiber, Cabrita, Ines, Kunzelmann, Karl, Andre Kraus, Kathrin Skoczynski, Kraus, Andre, Schreiber, Rainer, Scholz, Julia Katharina, Julia Katharina Scholz, Karl Kunzelmann, Ines Cabrita, Skoczynski, Kathrin, Björn Buchholz, Buchholz, Björn   +13 more
core   +1 more source