Results 1 to 10 of about 43,824 (207)

Detection of SARS-CoV-2 infection in thyroid follicular cells from a COVID-19 autopsy series

European Thyroid Journal, 2023
Objective: To understand whether thyroid cells can be directly infected by the SARS-CoV-2 virus and to establish a putative correlation with the expression of the host entry machinery: ACE-2, TMPRSS2, and furin.
Sofia Macedo, Ana Pestana, Liliana Santos, Celestino Neves, Susana Guimarães, Amaro Duarte-Neto, Marisa Dolhnikoff, Paulo Saldiva, Georgina Alves, Rute Oliveira, Didier Cabanes, Fátima Carneiro, Manuel Sobrinho-Simões, Paula Soares   +13 more
doaj   +1 more source

Skrining Potensi Essential Oil Cananga odorata dalam Penghambatannya Terhadap ACE II dan TMPRSS2 sebagai Anti Covid-19: Pendekatan In Silico

Jurnal Ilmiah Biosaintropis (Bioscience-Tropic), 2023
COVID-19 is a disease caused by viruses of the coronavirus class that are known to enter humans through the Angiotensin Coverting Enzyme (ACE II) receptor protein and transmembrane serine protease (TMPRSS 2).
Yoni Rina Bintari, Dian Novita Wulandari
doaj   +1 more source

Camostat Mesylate Versus Lopinavir/Ritonavir in Hospitalized Patients With COVID-19—Results From a Randomized, Controlled, Open Label, Platform Trial (ACOVACT)

Frontiers in Pharmacology, 2022
Background: To date, no oral antiviral drug has proven to be beneficial in hospitalized patients with COVID-19.Methods: In this randomized, controlled, open-label, platform trial, we randomly assigned patients ≥18 years hospitalized with COVID-19 ...
M. Karolyi, E. Pawelka, S. Omid, F. Koenig, V. Kauer, B. Rumpf, W. Hoepler, A. Kuran, H. Laferl, T. Seitz, M. Traugott, V. Rathkolb, M. Mueller, A. Abrahamowicz, C. Schoergenhofer, M. Hecking, A. Assinger, C. Wenisch, M. Zeitlinger, B. Jilma, A. Zoufaly, A. Zoufaly   +21 more
doaj   +1 more source

Optimization of East Java Propolis Extraction as Anti SARS-Cov-2 by Molecular Docking Study

Jurnal Ilmu dan Teknologi Hasil Ternak, 2022
The purpose of this research is to obtain the optimum propolis extraction method using microwave extraction so as to produce anti-SARS CoV-2 compounds. The research method used was experimental with a completely randomized factorial design consisting of ...
Sofia Aulia Hidayat, Agus Susilo, Khothibul Umam Al Awwaly, Miftakhul Cahyati   +3 more
doaj   +1 more source

The role of proteases in the invasion of SARS-CoV-2 virus into human host cells

Journal of Current Biomedical Reports, 2021
The new coronavirus, which originally broke out in Wuhan, China, in December 2019, increase quickly around the world, causing a pandemic all over the world. The virus uses its spike protein to enter the human host cells.
Maryam Saeidi, Fatemeh Rouhollah
doaj   +1 more source

Impact of TMPRSS2 Expression, Mutation Prognostics, and Small Molecule (CD, AD, TQ, and TQFL12) Inhibition on Pan-Cancer Tumors and Susceptibility to SARS-CoV-2

Molecules, 2022
As a cellular protease, transmembrane serine protease 2 (TMPRSS2) plays roles in various physiological and pathological processes, including cancer and viral entry, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Jiewen Fu, Shuguang Liu, Qi Tan, Zhiying Liu, Jie Qian, Ting Li, Jiaman Du, Binghui Song, Dabing Li, Lianmei Zhang, Jiayue He, Kan Guo, Baixu Zhou, Hanchun Chen, Shangyi Fu, Xiaoyan Liu, Jingliang Cheng, Tao He, Junjiang Fu   +18 more
doaj   +1 more source

Growing concerns on male reproductive health amidst COVID-19 pandemic

Journal of Family Medicine and Primary Care, 2022
Blood–testis barrier is body's innate mechanism to defend germ cells by creating a physical and immunological barrier. But some viral infections are known to evade it.
Megha Agrawal, Vikas Kumar, Gyan Vardhan
doaj   +1 more source

High Expression of ACE2 and TMPRSS2 at the Resection Margin Makes Lung Cancer Survivors Susceptible to SARS-CoV-2 With Unfavorable Prognosis

Frontiers in Oncology, 2021
BackgroundCoronavirus disease 2019 (COVID-19) has rapidly spread worldwide. Systematic analysis of lung cancer survivors at molecular and clinical levels is warranted to understand the disease course and clinical characteristics.MethodsA single-center ...
Qianqian Wang, Liangyu Li, Liangyu Li, Tianyu Qu, Jie Li, Jie Li, Lingxiang Wu, Lingxiang Wu, Kening Li, Kening Li, Ziyu Wang, Ziyu Wang, Mengyan Zhu, Mengyan Zhu, Bin Huang, Bin Huang, Wei Wu, Wei Wu, Min Wu, Min Wu, Rong Ding, Rong Ding, Zhihong Zhang, Qianghu Wang, Qianghu Wang, Xinyi Xia, Xinyi Xia, Xinyi Xia, Pengping Li, Pengping Li, Zhi Zhang, Renhua Guo   +31 more
doaj   +1 more source

A Pan-Cancer In Silico Analysis of the COVID-19 Internalization Protease: Transmembrane Proteaseserine-2

Frontiers in Genetics, 2022
The new coronavirus (2019-nCoV) is an emerging pathogen that can cause severe respiratory infections in humans. It is worth noting that many of the affected COVID-19 patients have malignant tumors.
Yiming Meng, Jing Sun, Guirong Zhang, Tao Yu, Haozhe Piao, Haozhe Piao   +5 more
doaj   +1 more source

Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial [PDF]

BioImpacts, 2020
Introduction: Bromhexine is a potential therapeutic option in COVID-19, but no data from a randomized clinical trial has been available. The present study aimed to evaluate the efficacy of bromhexine in intensive care unit (ICU) admission, mechanical ...
Khalil Ansarin, Ramin Tolouian, Mohammadreza Ardalan, Ali Taghizadieh, Mojtaba Varshochi, Soheil Teimouri, Tahere Vaezi, Hamed Valizadeh, Parviz Saleh, Saeid Safiri, Kenneth R. Chapman   +10 more
doaj   +1 more source