Results 91 to 100 of about 43,824 (207)

Establishment of stable Vero cell lines expressing TMPRSS2 and MSPL: A useful tool for propagating porcine epidemic diarrhea virus in the absence of exogenous trypsin

Virulence, 2020
Porcine epidemic diarrhea virus (PEDV) is the causative agent of porcine epidemic diarrhea, causing substantial economic losses to the swine industry worldwide.
Xiaona Wang, Xinyuan Qiao, Ling Sui, Haiyuan Zhao, Fengsai Li, Yan-Dong Tang, Wen Shi, Yuyao Guo, Yanping Jiang, Li Wang, Han Zhou, Lijie Tang, Yigang Xu, Yijing Li   +13 more
doaj   +1 more source

The Transmembrane Protease Serine 2 (TMPRSS2) Non-Protease Domains Regulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike-Mediated Virus Entry

Viruses, 2023
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters cells by binding to the angiotensin-converting enzyme 2 (hACE2) receptor. This process is aided by the transmembrane protease serine 2 (TMPRSS2), which enhances entry efficiency and ...
Romano Strobelt, Julia Adler, Yosef Shaul   +2 more
doaj   +1 more source

Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]

, 2011
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet, Amberg, Sean M, Chen, Yen Ting, Craik, Charles S, Goetz, David H, Hansell, Elizabeth, Lu, Kai, McKerrow, James, Roush, William R, Simmons, Graham, Zhou, Yanchen   +10 more
core   +1 more source

COVID‐19 and diabetic ketoacidosis: National outcomes, predictors, and resource utilization in the United States

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background The impact of COVID‐19 infection on diabetic ketoacidosis (DKA) outcomes remains incompletely characterized at a national level. Methods We analyzed adult DKA hospitalizations in the United States from the 2020–2021 National Inpatient Sample.
Jia Ee Chia, Song Peng Ang, Luis Chozet, Eunseuk Lee, Jose Iglesias   +4 more
wiley   +1 more source

Spiking dependence of SARS‐CoV‐2 pathogenicity on TMPRSS2

Journal of Medical Virology, 2021
AbstractEpidemiological data shows a discrepancy in COVID‐19 susceptibility and outcomes with some regions being more heavily affected than others. However, the factors that determine host susceptibility and pathogenicity remain elusive. An increasing number of publications highlight the role of Transmembrane Serine Protease 2 (TMPRSS2) in the ...
Asim Z. Abbasi, Dania A. Kiyani, Syeda M. Hamid, Muhammad Saalim, Ammad Fahim, Nasir Jalal   +5 more
openaire   +3 more sources

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression [PDF]

, 2015
The ERG gene is fused to TMPRSS2 in approximately 50% of prostate cancers (PrCa), resulting in its overexpression. However, whether this is the sole mechanism underlying ERG elevation in PrCa is currently unclear.
Asara, John M., Beck, Andrew H., Cheng, Liang, Dai, Xiangpeng, Gan, Wenjian, Huang, Jiaoti, Inuzuka, Hiroyuki, Li, Zhen, Liu, Pengda, Lunardi, Andrea, Pandolfi, Pier Paolo, Sun, Yin, Varmeh, Shoreh, Wei, Wenyi, Zhang, Jinfang   +14 more
core   +1 more source

Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome

Immunology, Volume 177, Issue 3, Page 596-612, March 2026.
Decreased fetal brain macrophages were previously reported in Ts1Cje mice, a model of Down syndrome (DS). We confirmed the reduction in primitive macrophages, brain macrophage precursors, using Ts1Cje‐derived mouse embryonic stem cells (Ts1Cje‐mESCs) and human induced pluripotent stem cells with trisomy 21 (Tri21‐hiPSCs), with in vivo validation ...
Koki Harada, Keiichi Ishihara, Sayaka Wakayama, Teruhiko Wakayama, Sae Yamamoto, Haruhiko Sago, Shun Shimohama, Satoshi Akiba, Florent Ginhoux, Kazuyuki Takata   +9 more
wiley   +1 more source

Genetic interaction between Tmprss2-ERG gene fusion and Nkx3.1-loss does not enhance prostate tumorigenesis in mouse models.

PLoS ONE, 2015
Gene fusions involving ETS family transcription factors (mainly TMPRSS2-ERG and TMPRSS2-ETV1 fusions) have been found in ~50% of human prostate cancer cases.
Douglas E Linn, Roderick T Bronson, Zhe Li   +2 more
doaj   +1 more source

Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians. [PDF]

, 2016
African-Americans are diagnosed with more aggressive prostate cancers and have worse survival than Caucasians, however a comprehensive understanding of this health disparity remains unclear.
Dahiya, Rajvir, Dasgupta, Pritha, Deng, Guoren, Hashimoto, Yutaka, Kato, Taku, Kulkarni, Priyanka, Kumar, Deepak, Majid, Shahana, Mitsui, Yozo, Saini, Sharanjot, Shiina, Marisa, Sumida, Mitsuho, Tabatabai, Laura, Tanaka, Yuichiro, Varahram, Shahryari, Yamamura, Soichiro   +15 more
core   +2 more sources

The X Factor in Immunity: Sex Differences Shaped by the X Chromosome

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic, Megan Wynalda, Montserrat C. Anguera   +2 more
wiley   +1 more source