Results 31 to 40 of about 43,824 (207)

Genetic variants in TMPRSS2 and Structure of SARS-CoV-2 spike glycoprotein and TMPRSS2 complex [PDF]

, 2020
AbstractSARS-CoV-2, a highly transmittable pathogen has infected over 3.8 million people around the globe. The spike glycoprotein of SARS-CoV-2 engages host ACE2 for adhesion, TMPRSS2 for activation and entry. With the aid of whole-exome sequencing, we report a variant rs12329760 inTMPRSS2gene and its mutant V160M, which might impede viral entry ...
Ravikanth Vishnubhotla, Naveen Vankadari, Vijayasarathy Ketavarapu, Ramars Amanchy, Steffie Avanthi, Govardhan Bale, Duvvur Nageshwar Reddy, Mitnala Sasikala   +7 more
openaire   +1 more source

TMPRSS2 Serves as a Prognostic Biomarker and Correlated With Immune Infiltrates in Breast Invasive Cancer and Lung Adenocarcinoma

Frontiers in Molecular Biosciences, 2022
TMPRSS2 is a transmembrane serine protease and plays a pivotal role in coronavirus disease 2019 (COVID-19). However, the correlation of TMPRSS2 with prognosis and immune infiltration in tumors has not yet been explored.
Xinhua Xiao, Huizhuang Shan, Yangyang Niu, Peihong Wang, Donghe Li, Yuyin Zhang, Jiayi Wang, Yingli Wu, Hua Jiang   +8 more
doaj   +1 more source

Is Low Alveolar Type II Cell SOD3 in the Lungs of Elderly Linked to the Observed Severity of COVID-19? [PDF]

, 2020
Human lungs single cell RNA sequencing data from healthy donors (elderly and young; GEO accession number GSE122960) were analyzed to isolate and specifically study gene expression in alveolar type II cells.
Abouhashem, Ahmed S., Azzazy, Hassan M. E., Sen, Chandan K., Singh, Kanhaiya   +3 more
core   +1 more source

Molecular docking between human TMPRSS2 and SARS-CoV-2 spike protein: conformation and intermolecular interactions

AIMS Microbiology, 2020
Entry of SARS-CoV-2, etiological agent of COVID-19, in the host cell is driven by the interaction of its spike protein with human ACE2 receptor and a serine protease, TMPRSS2.
Mushtaq Hussain, Nusrat Jabeen, Anusha Amanullah, Ayesha Ashraf Baig, Basma Aziz, Sanya Shabbir, Fozia Raza, Nasir Uddin   +7 more
doaj   +1 more source

Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells [PDF]

, 2013
The development and growth of prostate cancer is dependent on androgens; thus, the identification of androgen-regulated genes in prostate cancer cells is vital for defining the mechanisms of prostate cancer development and progression and developing new ...
Brinkmann, Chen, Ciara O'Hanlon-Brown, Claessens, Cleutjens, Cook, Cunha, Dai, Devos, Feldman, Greg N Brooke, Gregory, Haelens, Haelens, Ham, Heinlein, Jonathan Waxman, Laki Buluwela, Lin, Lu, Luke, Lund, Massie, Massie, Ngan, Nird  , Rennie, Rowling, Shang, Shen, Silvia Ottaviani, Simak Ali, Song, Sreekumar, Verrijdt, Wang, Yu   +36 more
core   +1 more source

Evidence of SARS-CoV-2 Transmission Through the Ocular Route

Clinical Ophthalmology, 2021
Jing-Yu Qu, Hua-Tao Xie, Ming-Chang Zhang Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of ChinaCorrespondence: Ming-Chang Zhang; Hua-Tao ...
Qu JY, Xie HT, Zhang MC
doaj  

ACE-2, TMPRSS2 and Beyond; Promising Targets and Tools for COVID-19 Prophylaxis and Treatment

Bezmiâlem Science, 2020
Several repurposing drugs and ongoing vaccine researches to combat Coronavirus Disease-19 (COVID-19) are testing clinically, worldwide. COVID-19 caused by severe acute respiratory failure syndrome-CoV-2, uses angiotensin-converting enzyme 2 (ACE-2) as a ...
Akçahan GEPDİREMEN, Meltem KUMAŞ
doaj   +1 more source

Ginsenosides, potential TMPRSS2 inhibitors, a trade-off between the therapeutic combination for anti-PD-1 immunotherapy and the treatment of COVID-19 infection of LUAD patients

Frontiers in Pharmacology, 2023
Background: Acting as a viral entry for coronavirus to invade human cells, TMPRSS2 has become a target for the prevention and treatment of COVID-19 infection.
Mei Meng, Rui Gao, Zixue Liu, Fengxiang Liu, Shiyu Du, Shiyu Du, Shiyu Du, Yizhi Song, Jian He   +8 more
doaj   +1 more source

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells [PDF]

, 2018
Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus.
A Milewska, A Pratelli, A Quan, Aleksandra Milewska, AM Zaki, Artur Szczepanski, B Hernaez, B Jancekova, BA Mainou, BJ Dille, C Burkard, C Kooi, C Liu, C Liu, D Dutta, DM Blau, E Dietzel, E Girard, E Hamme Van, EJ Bowman, F Samson, G Preta, GA Wudiri, GM Li, GR Ares, H Imhoff, H Lin, H Wang, IC Huang, IM Mackay, J Li, J Schindelin, J Somsel Rodman, JA Mitchell, JK Millet, JL Wang, JP Lim, JR Henley, Judy A. Mitchell, K Erles, K Erles, K Owczarek, K Shirato, K Shirato, Katarzyna Owczarek, Krzysztof Pyrc, KS Choi, L Kleist von, L Pelkmans, LH Wang, LJ Reed, M Marsh, MG Hemida, MJ Geisow, MJ Vincent, O Achour, O Heikkila, P Duckert, P Eifart, P Oh, Q Xu, R Nomura, S Bertram, S Bolte, S Gierer, S Matsuyama, SL Priestnall, TA Hill, VC Chu, X Ren, Y Inoue, Y Phonphok, Z Qian, Z Qinfen, Zbigniew Baster, Zenon Rajfur   +75 more
core   +8 more sources

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy. [PDF]

, 2017
Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications.
Alva, Ajjai S, Brockman, Scott, Chinnaiyan, Arul M, Chugh, Rashmi, Feng, Felix Y, Grasso, Catherine S, Gursky, Amy, Haakenson, Christine, Henderson, James, Herman, Kirk, Hovelson, Daniel H, Husain, Hatim, Hussain, Maha H, Kamberov, Emmanuel, Kandarpa, Malathi, Kang, Qing, Krauss, John C, Langmore, John, Liu, Chia-Jen, Lonigro, Robert J, Mills, Ryan E, Morgan, Todd M, Quist, Michael J, Ramnath, Nithya, Robinson, Dan, Smith, David C, Talpaz, Moshe, Tesmer, Tim, Tewari, Muneesh, Tomlins, Scott A, Tuck, Missy, Wang, Yugang   +31 more
core   +1 more source