Results 71 to 80 of about 43,824 (207)
The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms with COVID-19 severity
EXCLI Journal : Experimental and Clinical Sciences, 2022 Genes involved in the regulation of viral recognition and its entry into a host cell have been identified as candidates for genetic association studies on COVID-19 severity.
Zorana Dobrijević +6 more
doaj +1 more source
Advanced Science, EarlyView.In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo +14 more
wiley +1 more source
Performance of PCA3 and TMPRSS2:ERG urinary biomarkers in prediction of biopsy outcome in the Canary Prostate Active Surveillance Study (PASS). [PDF]
, 2019 BackgroundFor men on active surveillance for prostate cancer, biomarkers may improve prediction of reclassification to higher grade or volume cancer.
Bianchi-Frias, Daniella +16 more
core
Advanced Science, EarlyView.Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke +14 more
wiley +1 more source
The proteolytic activation of (H3N2) influenza A virus hemagglutinin is facilitated by different type II transmembrane serine proteases [PDF]
, 2016 Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is necessary for viral activation and infectivity. In humans and mice, members of the type II transmembrane protease family (TTSP), e.g., TMPRSS2, TMPRSS4, and TMPRSS11d (HAT), have ...
Bergmann, S. (Silke) +10 more
core +6 more sources
Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells [PDF]
, 2011 Nucleosome positioning at transcription start sites is known to regulate gene expression by altering DNA accessibility to transcription factors; however, its role at enhancers is poorly understood.
Andreu-Vieyra, Claudia +6 more
core +3 more sources
ChemMedChem, EarlyView.This study uses six small‐molecule inhibitors to evaluate optimal cellular accumulation assay conditions in a 96‐well format with high performance liquid chromatography with tandem mass spectrometry detection. The obtained medium to high‐throughput workflow is suitable for reliably identifying cellular accumulation, valuable for preclinical selection ...
Alina Metzen, Katharina Rox
wiley +1 more source
Frontiers in ImmunologyIntroductionSARS-CoV-2 and Mycobacterium tuberculosis (Mtb) share similarities in their modes of transmission, pathophysiological symptoms, and clinical manifestations.
Mary Ngongang Kameni +20 more
doaj +1 more source
Frontiers in Microbiology, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a widespread outbreak of highly pathogenic coronavirus disease 2019 (COVID-19). It is therefore important and timely to characterize interactions between the virus and host cell at ...
Jiya Sun +19 more
doaj +1 more source
Molecular characterization and clinical impact of TMPRSS2-ERG rearrangement on prostate cancer: comparison between FISH and RT-PCR [PDF]
, 2013 Prostate cancer (PCa) is a very heterogeneous disease, and there are constraints in its current diagnosis. Serum PSA levels, digital rectal examination (DRE), and histopathologic analysis often drive to overdiagnosis and overtreatment.
Calatrava, Ana +8 more
core +4 more sources