Detection of Tn, sialyn-Tn and T antigens in HNPCC
, 1996 The simple mucin-type carbohydrate antigens Tn, sialosyl-Tn, T and the 'cryptic' sialylated variant of the last represent the mucin core oligosaccharide structures that are produced in the initial steps of the mucin biosynthetic pathway.
G. BARRESI +4 more
core
Polymeric α‐Hairpinin Allergens Induce a Functional Response via a Single Antibody
Allergy, EarlyView.
Gage O. Leighton +16 more
wiley +1 more source
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Brain Pathology, EarlyView.Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová +19 more
wiley +1 more source
Development of a scalable synthesis of the Sialyl-Tn antigen
Amandeep Sehmbi Uwill abstract Development of a scalable synthesis of the Sialyl-Tn antigen Amandeep Sehmbi, Michael Reynolds, John F. Trant The sialyl-Tn antigen (sTn) is a naturally occurring carbohydrate commonly associated with epithelial cancers ...
Sehmbi, Amandeep
core +1 more source
Erratum to: Identification of Tn antigen O-GalNAc-expressing glycoproteins in human carcinomas using novel anti-Tn recombinant antibodies. [PDF]
Glycobiology, 2020 Matsumoto Y +12 more
europepmc +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Identification of Tn antigen O-GalNAc-expressing glycoproteins in human carcinomas using novel anti-Tn recombinant antibodies. [PDF]
Glycobiology, 2020 Matsumoto Y +12 more
europepmc +1 more source
TROP2 immunoreactivity in pulmonary large cell neuroendocrine carcinoma
Histopathology, EarlyView.Frequently positive TROP2 IHC suggests that TROP2 antibody‐drug conjugates may be potential treatments for LCNEC. Introduction TROP2 antibody‐drug conjugates have shown promising anti‐tumour activity, but neither the activity of these agents nor TROP2 expression has been well studied in pulmonary large cell neuroendocrine carcinoma (LCNEC), a rare and ...
Michael Minkley +6 more
wiley +1 more source
Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue. [PDF]
Chem Sci, 2020 Pifferi C +9 more
europepmc +1 more source