Results 201 to 210 of about 621,791 (286)

Efficacy and safety of frail patients treated with ciltacabtagene autoleucel in the real world: A Center for International Blood and Marrow Transplant Research analysis

Cancer, Volume 132, Issue 19, 1 October 2026.
Abstract Background Ciltacabtagene autoleucel (cilta‐cel), an anti–B‐cell maturation antigen (BCMA) chimeric antigen receptor T‐cell (CAR‐T) therapy, is approved for relapsed/refractory multiple myeloma (RRMM). Methods Using the Center for International Blood and Marrow Transplant Research registry, this study evaluated outcomes of frail patients ...
Hira Mian, Muhammad Salman Faisal, Tiening Chen, Ruta Brazauskas, Temitope Oloyede, Nausheen Ahmed, Aimaz Afrough, Larry D. Anderson, Rahul Banerjee, Jesus Berdeja, Aram Bidikian, Jakob Devos, Binod Dhakal, Ajoy Dias, Danai Dima, Yvonne A. Efebera, Lohith Gowda, Doris K. Hansen, Hamza Hashmi, Heather J. Landau, Lazaros Lekakis, Abu‐Sayeef Mirza, Ravi Narra, Krina Patel, Ashley E. Rosko, Mark Schroeder, Surbhi Sidana, Saad Usmani, Marcelo C. Pasquini, Taiga Nishihori, Othman Salim Akhtar, Meera Mohan   +31 more
wiley   +1 more source

Model‐Based Analysis with Mechanistic Insights to CAR‐T‐Cell Therapy Kinetics: Case Study with Axicabtagene Ciloleucel and Brexucabtagene Autoleucel

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1027-1040, October 2026.
Model‐informed drug development is increasingly used to support chimeric antigen receptor (CAR)‐T‐cell therapy programs. However, most population pharmacokinetic (PK) CAR‐T‐cell models available in literature are variations of an empirical piecewise‐linear model, which accurately describes the observed data but lacks a mechanistic foundation.
Anna M. Mc Laughlin, Martin Bergstrand, Ana Ruiz‐Garcia, Simone Filosto, Rhine Shen   +4 more
wiley   +1 more source

A cancer therapeutic vaccine based on clustered Tn-antigen mimetics induces strong antibody-mediated protective immunity. [PDF]

Angew Chem Int Ed Engl, 2014
Richichi B, Thomas B, Fiore M, Bosco R, Qureshi H, Nativi C, Renaudet O, BenMohamed L.   +7 more
europepmc   +1 more source

Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody. [PDF]

Angew Chem Int Ed Engl, 2015
Martínez-Sáez N, Castro-López J, Valero-González J, Madariaga D, Compañón I, Somovilla VJ, Salvadó M, Asensio JL, Jiménez-Barbero J, Avenoza A, Busto JH, Bernardes GJ, Peregrina JM, Hurtado-Guerrero R, Corzana F.   +14 more
europepmc   +1 more source

Adeno‐Associated Virus Vector‐Mediated Expression of Neuroligin 2 in the Mouse Hippocampus Attenuates the Progression of Pentylenetetrazol‐Induced Seizures

The Journal of Gene Medicine, Volume 28, Issue 10, October 2026.
Mice received bilateral hippocampal injections of an AAV vector expressing NL2, followed by repeated PTZ administration. NL2 expression in the HPC attenuated seizure progression and reduced c‐Fos expression in the ventral HPC. These findings suggest that AAV‐mediated NL2 expression in the HPC may be a potential therapeutic strategy for seizure control.
Tomohiro Tokutake, Akane Hara, Ayano Murayama, Yuto Mitsuda, Jun Yokose, Yusuke Yano, Yuki Shigetsura, Mika Ito, Naomi Takino, Shinichi Kumagai, Kuniko Shimazaki, Shin‐Ichi Muramatsu, Atsumi Nitta   +12 more
wiley   +1 more source

Predictors of Liver Steatosis Progression Among People Living With HIV in Low‐ and Middle‐Income Countries: A Multicentre Longitudinal Study

Journal of the International AIDS Society, Volume 29, Issue 10, October 2026.
ABSTRACT Introduction Liver steatosis is increasingly recognized as a major comorbidity in people living with HIV (PLWH), with growing evidence suggesting an increased risk of progression to advanced liver disease. We assessed predictors of liver steatosis progression over 36 months in PLWH from low‐ and middle‐income countries.
Marie K. Plaisy, Thierry Tiendrebeogo, Carlotta Mondoka, Mark H. Kuniholm, Rodrigo de Carvalho Moreira, Aggrey Semeere, Rohidas T. Borse, Albert Minga, Gilles Wandeler, Gad Murenzi, Brenda E. Crabtree‐Ramírez, Niharika Samala, Jeremy Ross, Ephrem Mensah, Ardele Mandiriri, Sandra W. Cardoso, Jean Paul Mivumbi, Lameck Diero, Haridas Prasad, Paola Alarcón Murra, Belinda V. Chihota, Suzanne Goodrich, Thida Chanyachukul, Ellen Brazier, Stephany N. Duda, Hugo Perazzo, Antoine Jaquet, the International epidemiology Databases to Evaluate AIDS (IeDEA)   +27 more
wiley   +1 more source

IgM promotes antitumor immunity to a Tn-expressing solid tumor. [PDF]

J Immunother Cancer
Nzuki HL, Jennings-Gee JE, Trivette M, Mosher TH, Adams-Sims AE, Hegarty AA, Haas KM.   +6 more
europepmc   +1 more source

The Microbiome in Glioblastoma: Mechanisms, Tumor–Immune Interactions, and Translational Perspectives

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Proposed microbiome‐related pathways and translational landscape in glioblastoma. Gut dysbiosis may alter microbial metabolites, inflammatory mediators, barrier integrity, immune signaling, and vagal communication, thereby influencing the GBM neuroimmune microenvironment.
Tareq Nayef AlRamadneh, Renuka Jyothi‐S, Priya Priyadarshini‐Nayak, Anima Nanda, Shaker Al‐Hasnaawei, Akanksha Bhatt, Ashish Singh‐Chauhan, Siya Singla, Manoj Kumar Mishra   +8 more
wiley   +1 more source

CAR T Cells Targeting O-Glycosylated Fibronectin Exhibit Potent Cytolytic Activity and Combine with Tumoral Toll-Like Receptor Agonism to Overcome Tumor Resistance. [PDF]

Cancer Immunol Res
King-Peoples TR, Keane JT, Lewis HS, Liu F, Brookens SK, Dagher OK, Parvathaneni K, Gardner BL, Ahmed A, Furth EE, Lal P, Posey AD.   +11 more
europepmc   +1 more source

O‐GlcNAcylation Stimulation Modulates Na+/K+ ATPase and Improves Outcomes in Hemorrhagic Shock

MedComm, Volume 7, Issue 10, October 2026.
Acute stimulation of O‐GlcNAcylation via NButGT injections in rats subjected to hemorrhagic shock improves hemodynamic parameters, reduces organ dysfunction, and restores ionic imbalance. These beneficial effects are notably mediated through modulation of the Na+/K+‐ATPase pump, highlighting O‐GlcNAcylation as a promising therapeutic target in ...
Thomas Dupas, Amandine Vergnaud, Virginie Aillerie, Martin Bouaud, Angélique Erraud, Thomas Pelé, Antoine Persello, Barbara Ribeiro de Oliveira, Jérôme Montnach, Aurore Girardeau, Jules Lecomte, Nolwenn Tessier, Mathilde Guyon, Angélique Blangy‐Letheule, Matthieu Rivière, Jacques Lebreton, Arnaud Tessier, Edith Bigot‐Corbel, Aurélia A. Leroux, Michel De Waard, Nicolas J. Prat, Bertrand Rozec, Manon Denis, Benjamin Lauzier   +23 more
wiley   +1 more source