Results 251 to 260 of about 81,953 (280)

Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in Cosmc

Cancer Research, 2008
Abstract Neoplastic lesions typically express specific carbohydrate antigens on glycolipids, mucins, and other glycoproteins. Such antigens are often under epigenetic control and are subject to reversion and loss upon therapeutic selective pressure.
Tongzhong, Ju, Grainger S, Lanneau, Tripti, Gautam, Yingchun, Wang, Baoyun, Xia, Sean R, Stowell, Margaret T, Willard, Wenyi, Wang, Jonathan Y, Xia, Rosemary E, Zuna, Zoltan, Laszik, Doris M, Benbrook, Marie H, Hanigan, Richard D, Cummings   +13 more
openaire   +2 more sources

Synthesis of Sulfur-Containing Analogues of ΑGalNAc (Tn-Antigen) and ΒGal1,3ΑGalNAc (T-Antigen)

Monatshefte f?r Chemie / Chemical Monthly, 2002
A method for the preparation of thio-analogues of the T- and Tn-antigen was developed. Thus, starting from a known N-acetamido-glucoside derivative, the epidithio analogue of the Tn-antigen was accessible in a four-step reaction sequence. The corresponding epidithio analogue and the thioanhydro derivative of the T-antigen were synthesized starting from
Wenzl, Irmgard, Neuwirth, Norbert, Hedenetz, Alexander, Fiedler, Christian, Streicher, Hansjörg, Unger, Frank M., Schmid, Walther   +6 more
openaire   +2 more sources

TN, A General Carcinoma-Associated Antigen

1985
Abstract Tn antigen, the immediate precursor in the biosynthesis of T (Thomsen-Friedenreich) antigen does not occur in immunoreactive form in healthy tissues. However, we found it in about 90% of all primary carcinomas (CAs) and their metastases, as well as in the two T lymphomas studied. Thus, Tn is a CA-associated antigen.
G.F. SPRINGER, H. TEGTMEYER, P.R. DESAI, E.F. SCANLON, C.R. TAYLOR   +4 more
openaire   +1 more source

Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer.

Cancer research, 1989
Mucin glycoproteins are major secretory products of the colon and contain O-linked oligosaccharides synthesized on a polypeptide backbone. The initial step in the synthesis of O-linked oligosaccharides is the addition of N-acetylgalactosamine to serine or threonine residues forming the Tn antigen. This substance can then receive additional carbohydrate
S H, Itzkowitz, M, Yuan, C K, Montgomery, T, Kjeldsen, H K, Takahashi, W L, Bigbee, Y S, Kim   +6 more
openaire   +1 more source

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Boris Boll, Peter Schellongowski   +2 more
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Rujul H Parikh, Sagar Lonial
exaly  

Expression of Tn and sialyl Tn antigens in synovial tissues in rheumatoid arthritis.

Clinical and experimental rheumatology, 2010
The carbohydrate chains represented by mucins (MUCs) are expressed by a variety of normal and malignant secretory epithelial cells and induce a variety of immunoreactions. Tn and sialyl Tn antigens are tumour-associated carbohydrate antigens which are borne on the core proteins of mucins.
H, Ishino, Y, Kawahito, M, Hamaguchi, N, Takeuchi, D, Tokunaga, T, Hojo, M, Wada, A, Yamamoto, M, Kadoya, Y, Tsubouchi, M, Kohno, H, Nakada   +11 more
openaire   +1 more source

A guide to antigen processing and presentation

Nature Reviews Immunology, 2022
Novalia Pishesha, Thibault J Harmand, Hidde L Ploegh   +2 more
exaly  

Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity

Cell, 2023
Leyuan Ma
exaly  

MR1 antigen presentation to MAIT cells and other MR1-restricted T cells

Nature Reviews Immunology, 2023
Hamish E G Mcwilliam, JOSÉ A Villadangos, Villadangos JOSÉ A   +2 more
exaly