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MOLECULAR ANALYSIS OF BRCA1/2 GENES AND MULTIGENE-PANEL TESTING IN SICILIAN TRIPLE NEGATIVE BREAST CANCER [PDF]
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Seminars in Cancer Biology, 2022
Triple-negative breast cancer (TNBC) is a broad collection of breast cancer that tests negative for estrogen receptors (ER), progesterone receptors (PR), and excess human epidermal growth factor receptor 2 (HER2) protein. TNBC is considered to have poorer prognosis than other types of breast cancer because of a lack of effective therapeutic targets ...
Zhan Hua, Jason White, Jianjun Zhou
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Triple-negative breast cancer (TNBC) is a broad collection of breast cancer that tests negative for estrogen receptors (ER), progesterone receptors (PR), and excess human epidermal growth factor receptor 2 (HER2) protein. TNBC is considered to have poorer prognosis than other types of breast cancer because of a lack of effective therapeutic targets ...
Zhan Hua, Jason White, Jianjun Zhou
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Accelerating AXL targeting for TNBC therapy
The International Journal of Biochemistry & Cell Biology, 2021The tyrosine kinase receptor AXL of the TAM (TYRO3, AXL and MERTK) family is considered as a promising therapeutic target for different hematological cancers and solid tumors. AXL is involved in multiple pro-tumorigenic processes including cell migration, invasion, epithelial-mesenchymal transition (EMT), and stemness, and recent studies demonstrated ...
Lohit Khera, Sima Lev
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AKT inhibition improves OS in TNBC [PDF]
Nature Reviews Clinical Oncology, 2020 exaly +3 more sources
Pembrolizumab can delay progression of TNBC
Nature Reviews Clinical Oncology, 2020exaly +3 more sources
The Achilles heel of TNBCs: Ferroptosis heterogeneity
Cell Metabolism, 2023Resistance to ferroptosis, a form of programmed cell death, is associated with the development of some refractory cancers. In this issue, Yang et al. systematically illustrate the ferroptosis heterogeneity in triple-negative breast cancers (TNBCs) and reveal an innovative immunotherapy combination strategy for the luminal androgen receptor (LAR ...
Li, Jiang, Xiao-Meng, Gao, Ji, Cao
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