Results 51 to 60 of about 74,225 (263)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Duku peel ethyl acetate extract as an adjunctive treatment of doxorubicin on triple negative breast cancer 4T1 cells

Indonesian Journal of Biotechnology
Triple‐negative breast cancer (TNBC) faces significant treatment challenges due to its resistance to chemotherapy and high‐rate metastatic occurrence.
Faaza Aulia Rahman, Aulia Nur Septiani, Desty Restia Rahmawati, Novia Permata Hapsari, Edy Meiyanto, Ratna Asmah Susidarti   +5 more
doaj   +1 more source

Real-World Efficacy and Safety of the KEYNOTE-522 Protocol for Neoadjuvant Triple-Negative Breast Cancer: A Single-Center Experience. [PDF]

Batna Journal of Medical Sciences
Triple-negative breast cancer (TNBC), defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression, is an aggressive subtype associated with a high risk of relapse and ...
Assia BENSALEM, Khouloud BRAHIMI, Abdelaziz AMMARI, Sihem BENSALEM, Nour Djihane BOUATROUS, Meryem BOUDJERDA   +5 more
doaj   +1 more source

MSLN and basal markers expression in TNBC.

, 2014
Abbreviations: MSLN = mesothelin; TNBC = triple negative breast carcinomas. *CK5/6 status unknown for 3 cases, CK14 status unknown for 17 cases, EGFR status unknown for 9 cases.MSLN and basal markers expression in TNBC.
Gary Tozbikian (674932), Prasad S. Adusumilli (341164), Sujata Patil (674937), Jorge S. Reis-Filho (265332), Britta Weigelt (40755), Alice Y. Ho (674938), Muzaffar Akram (674936), Hannah Yong Wen (674939), Larry Norton (8447), Edi Brogi (674933), Kyuichi Kadota (674934), Jeffrey Catalano (674935)   +11 more
core   +1 more source

Cdh1 Deficiency Sensitizes TNBC Cells to PARP Inhibitors

, 2022
Triple-negative breast cancer (TNBC) is a type of breast tumor that currently lacks options for targeted therapy. Tremendous effort has been made to identify treatment targets for TNBC.
Lan, Mengjiao, Peng, Jin, Xu, Yongfeng, Xiong, Qunli, Zhu, Qing, Jinlu Liu, Pumin Zhang, Ying Zhou, Li, Junjun, Zhang, Zhiwei, Qunli Xiong, Junjun Li, Yongfeng Xu, Zhu Zeng, Zhiwei Zhang, Qing Zhu, Wu, Wei, Mengjiao Lan, Yang, Yang, Zhou, Ying, Xiaojuan Yang, Zhang, Pumin, Liu, Jinlu, Wei Wu, Yang Yang, Yang, Xiaojuan, Jin Peng, Zeng, Zhu   +27 more
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Development of nanocomplex mimic‐hsa‐miR‐143‐3p loaded exosome (exo‐miR) to inhibit viability, migration and proliferation of triple‐negative breast cancer

Indonesian Journal of Biotechnology
Breast cancer represents the highest number of cancer cases in Indonesia, with triple‐negative breast cancer (TNBC) being a common subtype (10–15%). MicroRNAs play a role in cancer epigenetics and contributing as core factors to the disease.
Fita Nilasari, Sofia Mubarika Haryana, Dwi Aris Agung Nugrahaningsih, Pamungkas Bagus Satriyo   +3 more
doaj   +1 more source

miRNA-gene relations with a potential role in TNBC.

, 2015
TNBC query (blue edges) refers to relations retrieved by miRTex by querying for ‘ “triple negative breast cancer” OR TNBC’; TNBC down-regulated gene query (red edges) refers to relations retrieved by miRTex by querying with a list of 252 gene down ...
Yifan Peng (800374), Karen E. Ross (800373), K. Vijay-Shanker (781828), Gang Li (34549), Cecilia N. Arighi (781826), Cathy H. Wu (14336)   +5 more
core   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source