Results 31 to 40 of about 82,941 (302)

PD-L1 expression in triple-negative breast cancer: a cross-sectional study in a Polish population

Polish Journal of Pathology, 2021
Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast carcinomas and represents an aggressive variant with a high mortality rate. PD-L1 is a protein that plays a pivotal role in suppressing the adaptive immune system.
Łukasz Szylberg, Ewa Antoniewicz, Wojciech Olszewski, Adam Kowalewski, Marek Zdrenka, Beata Dziekan, Matthew Ibbs, Violetta Filas, Andrzej Marszałek   +8 more
doaj   +1 more source

Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer

Cells, 2020
Triple-negative breast cancer (TNBC) stands out for its aggressiveness and accelerated rate of proliferation. Evidence shows that exercise may exert antitumorigenic effects, but the biochemical mechanisms underlying them remain unclear. Our objective was
Anderson Vulczak, Anderson de Oliveira Souza, Gustavo Duarte Ferrari, Ana Elisa Caleiro Seixas Azzolini, Gabriela Pereira-da-Silva, Luciane Carla Alberici   +5 more
doaj   +1 more source

HDAC inhibition potentiates immunotherapy in triple negative breast cancer. [PDF]

, 2017
Triple-negative breast cancer (TNBC) represents a more aggressive and difficult subtype of breast cancer where responses to chemotherapy occur, but toxicity is significant and resistance often follows. Immunotherapy has shown promising results in various
Ali, Niwa, Budillon, Alfredo, Krings, Gregor, Munster, Pamela N, Park, Jeenah, Pawlowska, Nela, Rosenblum, Michael D, Terranova-Barberio, Manuela, Thomas, Scott   +8 more
core   +1 more source

The Molecular Mechanisms behind Advanced Breast Cancer Metabolism: Warburg Effect, OXPHOS, and Calcium

Frontiers in Bioscience-Landmark
Altered metabolism represents a fundamental difference between cancer cells and normal cells. Cancer cells have a unique ability to reprogram their metabolism by deviating their reliance from primarily oxidative phosphorylation (OXPHOS) to glycolysis, in
Erna Mitaishvili, Hanna Feinsod, Zachary David, Jessica Shpigel, Chelsea Fernandez, Moira Sauane, Columba de la Parra   +6 more
doaj   +1 more source

Combined Analysis of Disseminated Tumor Cells (DTCs) and Circulating Tumor DNA (ctDNA) in a Patient Suffering from Triple Negative Breast Cancer Revealed Elevated Risk

Frontiers in Bioscience-Landmark, 2022
Background: Disseminated tumor cells (DTCs) in bone marrow aspirates of patients with primary breast cancer may serve as independent prognostic markers associated with impaired survival.
Ivonne Nel, Henrike Herzog, Bahriye Aktas   +2 more
doaj   +1 more source

Paracrine Signaling from Breast Cancer Cells Causes Activation of ID4 Expression in Tumor-Associated Macrophages

Cells, 2020
Background: Tumor-associated macrophages (TAMs) constitute a major portion of the leukocyte infiltrate found in breast cancer (BC). BC cells may reprogram TAMs in a pro-angiogenic and immunosuppressive sense.
Sara Donzelli, Andrea Sacconi, Chiara Turco, Enzo Gallo, Elisa Milano, Ilaria Iosue, Giovanni Blandino, Francesco Fazi, Giulia Fontemaggi   +8 more
doaj   +1 more source

Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry assay. [PDF]

, 2017
BackgroundGlucocorticoid receptor (GR) activity plays a role in many aspects of human physiology and may play a crucial role in chemotherapy resistance in a wide variety of solid tumors.
Block, Thaddeus S, Lynch, Frank J, Munster, Pamela N, Murphy, Tiffany I, Nguyen, Dat P   +4 more
core   +2 more sources

Regulatory Effect of miR497-5p–CCNE1 Axis in Triple-Negative Breast Cancer Cells and Its Predictive Value for Early Diagnosis [Retraction]

Cancer Management and Research, 2023
Liu WW, Li WD, Zhang YJ, Zhang ML. Cancer Manag Res. 2021;13:439–447. Following publication of the article, the authors raised concerns over the duplication of the two bar charts in Figure 5D.
Liu WW, Li WD, Zhang YJ, Zhang ML
doaj  

Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer. [PDF]

, 2017
Breast cancer remains the leading cause of cancer death in women owing to metastasis and the development of resistance to established therapies. Macrophages are the most abundant immune cells in the breast tumor microenvironment and can both inhibit and ...
A Fantozzi, A Sica, Ainhoa Mielgo, Almudena Santos, B Ruffell, B Weigelt, BA Pulaski, BP Schneider, BZ Qian, C Marquette, Carlos Figueiredo, CD Mills, CJ Aslakson, CT Guy, CX Ma, D Ohlund, Dean Hammond, DF Quail, DF Quail, DG DeNardo, DH Fagan, DL Dexter, EA Rakha, EM Fox, EY Lin, F Klemm, Fiona Campbell, HA Wahba, JB Wyckoff, JE Maglione, JFR Robertson, JL Gooch, K Friedbichler, KA Lodhia, KM Bussard, KR Bauer, L Bingle, L Ireland, Lesley G. Ellies, Lucy Ireland, M Augsten, M Guha, M Pollak, MC Schmid, Michael Schmid, MJ Campbell, OC Olson, PJ Murray, RD Leek, RL Jones, RL Siegel, S Massarweh, SA Davie, SK Denduluri, SM Farabaugh, SR Nielsen, T Shree, TD Schmittgen, Thomas Bogenrieder, Ulrike Weyer-Czernilofsky, V Bronte, WJ Gradishar, XHF Zhang, Y Mao, YH Lu, YH Zhang, YW Wan   +66 more
core   +2 more sources

Revealing Cellular Heterogeneity and Key Regulatory Factors of Triple-Negative Breast Cancer through Single-Cell RNA Sequencing

Frontiers in Bioscience-Landmark
Background: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC). TNBC has a poor prognosis due to high intratumoral heterogeneity and metastasis, pointing to the need to explore distinct molecular subtypes and gene ...
Hu Zhang, Yanan Sun, Xinna Du
doaj   +1 more source