Results 21 to 30 of about 51,359 (249)

Neural Functions Play Different Roles in Triple Negative Breast Cancer (TNBC) and non-TNBC [PDF]

Scientific Reports, 2020
AbstractTriple negative breast cancer (TNBC) represents the most malignant subtype of breast cancer, and yet our understanding about its unique biology remains elusive. We have conducted a comparative computational analysis of transcriptomic data of TNBC and non-TNBC (NTNBC) tissue samples from the TCGA database, focused on genes involved in neural ...
Renbo Tan, Haoyang Li, Zhenyu Huang, Yi Zhou, Mingxin Tao, Xin Gao, Ying Xu   +6 more
openaire   +3 more sources

Luminescent iridium(III)-pyridyl based complexes: tumor inhibitory studies in 4T1 mammary carcinoma mice model [PDF]

Exploration of Drug Science
Aim: The iridium(III) [Ir(III)] complexes exhibit anticancer properties, and along with their photoluminescence properties, they can be employed as diagnostic agents. Hence, we have tried to evaluate both properties.
Natesan Sundarmurthy Karthikeyan, Shishu Kant Suman, Prasad P. Phadnis, Lalrinawma Zote, Chandan Kumar, Vasanthakumaran Sudarsan   +5 more
doaj   +1 more source

A master regulator of cholesterol biosynthesis constitutes a therapeutic liability of triple negative breast cancer

Molecular & Cellular Oncology, 2020
Lipid and cholesterol reprogramming are often observed in specific cancer subtypes. We find that triple-negative breast cancers (TNBCs), but not estrogen receptor-positive (ER+) ones, adopt nuclear receptor RAR-related orphan receptor γ (RORγ) as their ...
Demin Cai, Xiong Zhang, Hong-Wu Chen
doaj   +1 more source

Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer

Cells, 2020
Triple-negative breast cancer (TNBC) stands out for its aggressiveness and accelerated rate of proliferation. Evidence shows that exercise may exert antitumorigenic effects, but the biochemical mechanisms underlying them remain unclear. Our objective was
Anderson Vulczak, Anderson de Oliveira Souza, Gustavo Duarte Ferrari, Ana Elisa Caleiro Seixas Azzolini, Gabriela Pereira-da-Silva, Luciane Carla Alberici   +5 more
doaj   +1 more source

Combined Analysis of Disseminated Tumor Cells (DTCs) and Circulating Tumor DNA (ctDNA) in a Patient Suffering from Triple Negative Breast Cancer Revealed Elevated Risk

Frontiers in Bioscience-Landmark, 2022
Background: Disseminated tumor cells (DTCs) in bone marrow aspirates of patients with primary breast cancer may serve as independent prognostic markers associated with impaired survival.
Ivonne Nel, Henrike Herzog, Bahriye Aktas   +2 more
doaj   +1 more source

The Molecular Mechanisms behind Advanced Breast Cancer Metabolism: Warburg Effect, OXPHOS, and Calcium

Frontiers in Bioscience-Landmark
Altered metabolism represents a fundamental difference between cancer cells and normal cells. Cancer cells have a unique ability to reprogram their metabolism by deviating their reliance from primarily oxidative phosphorylation (OXPHOS) to glycolysis, in
Erna Mitaishvili, Hanna Feinsod, Zachary David, Jessica Shpigel, Chelsea Fernandez, Moira Sauane, Columba de la Parra   +6 more
doaj   +1 more source

The Potential of PSMA as a Vascular Target in TNBC

Cells, 2023
Recent studies proving prostate-specific membrane antigen (PSMA) expression on triple-negative breast cancer (TNBC) cells and adjacent endothelial cells suggest PSMA as a promising target for therapy of until now not-targetable cancer entities. In this study, PSMA and its isoform expression were analyzed in different TNBC cells, breast cancer stem ...
Amelie Heesch, Lars Ortmanns, Jochen Maurer, Elmar Stickeler, Sabri E. M. Sahnoun, Felix M. Mottaghy, Agnieszka Morgenroth   +6 more
openaire   +5 more sources

Paracrine Signaling from Breast Cancer Cells Causes Activation of ID4 Expression in Tumor-Associated Macrophages

Cells, 2020
Background: Tumor-associated macrophages (TAMs) constitute a major portion of the leukocyte infiltrate found in breast cancer (BC). BC cells may reprogram TAMs in a pro-angiogenic and immunosuppressive sense.
Sara Donzelli, Andrea Sacconi, Chiara Turco, Enzo Gallo, Elisa Milano, Ilaria Iosue, Giovanni Blandino, Francesco Fazi, Giulia Fontemaggi   +8 more
doaj   +1 more source

Regulatory Effect of miR497-5p–CCNE1 Axis in Triple-Negative Breast Cancer Cells and Its Predictive Value for Early Diagnosis [Retraction]

Cancer Management and Research, 2023
Liu WW, Li WD, Zhang YJ, Zhang ML. Cancer Manag Res. 2021;13:439–447. Following publication of the article, the authors raised concerns over the duplication of the two bar charts in Figure 5D.
Liu WW, Li WD, Zhang YJ, Zhang ML
doaj  

Revealing Cellular Heterogeneity and Key Regulatory Factors of Triple-Negative Breast Cancer through Single-Cell RNA Sequencing

Frontiers in Bioscience-Landmark
Background: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC). TNBC has a poor prognosis due to high intratumoral heterogeneity and metastasis, pointing to the need to explore distinct molecular subtypes and gene ...
Hu Zhang, Yanan Sun, Xinna Du
doaj   +1 more source