Results 11 to 20 of about 597,646 (216)
Frontiers in Immunology, 2021 BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has infected over 112M patients and resulted in almost 2.5M deaths worldwide.
Esmaeil Mortaz +15 more
doaj +1 more source
Critical role of tumor necrosis factor-α in the early process of wound healing in skin
Journal of Dermatology and Dermatologic Surgery, 2017 Tumor necrosis factor (TNF)-α is quickly released and initiates inflammation at wound tissues, but its precise role in wound healing is not fully understood.
Masae Ritsu +7 more
doaj +1 more source
Physiological Reports, 2021 Intravenous infusion of relatively higher doses of angiotensin II (AngII) elicits natriuresis as opposed to its usual anti‐natruretic response. As AngII can induce tumor necrosis factor‐α (TNFα) production which elicits natriuresis via its action on TNFα
Dewan S. A. Majid, Alexander Castillo
doaj +1 more source
TNF-α in Uveitis: From Bench to Clinic
Frontiers in Pharmacology, 2021 Uveitis is an inflammation of the iris, ciliary body, vitreous, retina, or choroid, which has been shown to be the first manifestation of numerous systemic diseases.
Qi Jiang +6 more
doaj +1 more source
Copper-Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF-α/ATP7A Axis. [PDF]
Adv Sci (Weinh)This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xiao X +7 more
europepmc +2 more sources
Pulmonary artery perfusion with anti-tumor necrosis factor alpha antibody reduces cardiopulmonary bypass-induced inflammatory lung injury in a rabbit model. [PDF]
PLoS ONE, 2013 Inflammatory lung injury is one of the main complications associated with cardiopulmonary bypass (CPB). Tumor necrosis factor-α (TNF-α) is one of the key factors mediating the CPB-induced inflammatory reactions.
Yang Yu +4 more
doaj +1 more source
TNF‐α polymorphisms affect persistence and progression of HBV infection
Molecular Genetics & Genomic Medicine, 2019 Background Hepatitis B virus (HBV) infections are a major threat worldwide. Disease progression and outcome is diverse and depends on host genetic background. Recently, a high rate of HBV reactivation in individuals receiving tumor necrosis factor‐α (TNF‐
Anna Woziwodzka +6 more
doaj +1 more source
Regulatory T cells in Crohn's disease following anti‐TNF‐α therapy
JGH Open, 2020 Background and Aim Anti‐tumor necrosis factor alpha (TNF‐α) therapy is an effective therapy for Crohn's disease (CD). We investigated FoxP3+ and CD127− regulatory T cells (Tregs) before and after administration of anti‐TNF‐α therapy in CD.
Toshimi Chiba +6 more
doaj +1 more source
The TNF-α-308G/A Gene Polymorphism and Serum TNF-α Levels in Women With Preeclampsia
Journal of Family and Reproductive Health, 2022 Objective: Worldwide, preeclampsia (PE) is a multifactorial disorder reported in 2–5% of pregnancies, which increases mortality during pregnancy. In general, 10–15% of maternal deaths are directly related to PE and eclampsia.
Allahdad Khodadadi +4 more
doaj +1 more source
Neurobiology of Disease, 2009 TNF-α has been reported to be relevant in stroke-induced neuronal death. However the precise function of TNF-α in brain ischemia remains controversial since there are data supporting either a detrimental or a protective effect. Here we show that TNF-α is
Nahuai Badiola +6 more
doaj +1 more source