Association between TNF-α polymorphisms and responsiveness to TNF-α blockers in ankylosing spondylitis and psoriatic arthritis: a meta-analysis [PDF]
Scientific ReportsTo investigate the association between tumor necrosis factor-alpha (TNF-α) polymorphisms and the responsiveness to anti-TNF-α therapy in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA).
Young Ho Lee, Gwan Gyu Song
doaj +2 more sources
Mechanism of inhibitory effect of atorvastatin on resistin expression induced by tumor necrosis factor-α in macrophages [PDF]
Journal of Biomedical Science, 2009 Atorvastatin has been shown to reduce resistin expression in macrophages after pro-inflammatory stimulation. However, the mechanism of reducing resistin expression by atorvastatin is not known. Therefore, we sought to investigate the molecular mechanisms
Chua Su-Kiat +3 more
doaj +3 more sources
Promising TNF-α inhibitors: Targeting pathogenic TNF-α/TNFR signaling to restore Th17/Treg balance in rheumatoid arthritis [PDF]
Journal of Pharmaceutical AnalysisThe pleiotropic regulatory effect of tumor necrosis factor-alpha (TNF-α), an essential cytokine involved in immune regulation, is of significant importance in the immune response.
Jiajie Kuai +4 more
doaj +2 more sources
Assessment of IL6 and TNF α in Chronic Lymphocytic Leukemia [PDF]
International Journal of Medical Arts, 2022 Background: Among the cytokines and inflammatory markers, Interleukin 6 [IL6] and TNF α are the most common markers in the practice of medicine. Many studies determine the values of these two markers among the patients with chronic lymphocytic leukemia ...
Mohamed Abd-El-Haleem Mousa +3 more
doaj +1 more source
IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells. [PDF]
, 2012 Connective tissue growth factor (CTGF/CCN2) is an angiogenetic and profibrotic factor, acting downstream of TGF-β, involved in both airway- and vascular remodeling.
Fehrholz, Markus +6 more
core +16 more sources
Assessment of Anti-TNF-α Activities in Keratinocytes Expressing Inducible TNF- α: A Novel Tool for Anti-TNF-α Drug Screening. [PDF]
PLoS ONE, 2016 Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine important in normal and pathological biological processes. Newly synthesized pro-TNF-α is expressed on the plasma membrane and cleaved to release soluble TNF-α protein: both are ...
Sutthirat Udommethaporn +3 more
doaj +1 more source
Experimental Gerontology, 2023 Tumor necrosis factor (TNF)-α is a proinflammatory cytokine involved in the pathogenesis of sarcopenia, but its short half-life and inconsistent reproducibility limit the potential of TNF-α to be an ideal sarcopenia biomarker.
Wei-Ju Lin +7 more
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Serum TGF-β and TNF-α During Psoriasis Therapy with Narrowband Ultraviolet B [PDF]
American Journal of Applied Sciences, 2014 Although it is now an accepted concept that narrow-band UVB therapy is an efficacious therapy for psoriasis, the relationship between the response rate and the potential effects on serum cytokines is less well-established. The purpose of this study was to investigate the correlation between the response rate and the changes of serum TGF-I² and TNF-I ...
Ahmad Taha Khalaf, Yan Yuehua
openaire +1 more source
Melatonin attenuates oxidative stress and modulates inflammatory response after experimental burn trauma [PDF]
, 2018 Introduction. Thermal injury activates an inflammatory response. Melatonin possesses anti-oxidant and anti-inflammatory properties. The objective of the present work was to study melatonin effects on the inflammatory response under ...
Atanasova, Milena +3 more
core +7 more sources
Tristetraprolin Down-Regulation Contributes to Persistent TNF-Alpha Expression Induced by Cigarette Smoke Extract through a Post-Transcriptional Mechanism. [PDF]
PLoS ONE, 2016 Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD).
Xue-Ke Zhao +20 more
doaj +1 more source