Results 11 to 20 of about 2,494,759 (166)

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

bioRxiv, 2020
The COVID-19 pandemic has caused significant morbidity and mortality. Currently, there is a critical shortage of proven treatment options and an urgent need to understand the pathogenesis of multi-organ failure and lung damage.
Rajendra Karki, B. Sharma, Shraddha Tuladhar, E. P. Williams, Lillian Zalduondo, Parimal Samir, M. Zheng, Balamurugan Sundaram, Balaji Banoth, R. K. Subbarao Malireddi, Patrick Schreiner, Geoffrey Neale, Peter Vogel, R. Webby, C. Jonsson, T. Kanneganti   +15 more
semanticscholar   +1 more source

TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

Cell Death and Disease, 2021
Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes within these networks and both are associated with disruption of gut ...
J. Woznicki, N. Saini, P. Flood, Subhasree Rajaram, Ciaran M. Lee, Panagiota Stamou, Agnieszka Skowyra, Milan Bustamante-Garrido, Karine Regazzoni, N. Crawford, S. McDade, D. Longley, P. Aza‐Blanc, F. Shanahan, S. Zulquernain, J. McCarthy, S. Melgar, B. Mcrae, K. Nally   +18 more
semanticscholar   +1 more source

Tristetraprolin Down-Regulation Contributes to Persistent TNF-Alpha Expression Induced by Cigarette Smoke Extract through a Post-Transcriptional Mechanism. [PDF]

PLoS ONE, 2016
Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD).
Xue-Ke Zhao, Pulin Che, Ming-Liang Cheng, Quan Zhang, Mao Mu, Hong Li, Yuan Luo, Yue-Dong Liang, Xin-Hua Luo, Chang-Qing Gao, Patricia L Jackson, J Michael Wells, Yong Zhou, Meng Hu, Guoqiang Cai, Victor J Thannickal, Chad Steele, J Edwin Blalock, Xiaosi Han, Ching-Yi Chen, Qiang Ding   +20 more
doaj   +1 more source

The Role of TNF-α and Anti-TNF-α Agents during Preconception, Pregnancy, and Breastfeeding

International Journal of Molecular Sciences, 2021
Tumor necrosis factor-alpha (TNF-α) is a multifunctional Th1 cytokine and one of the most important inflammatory cytokines. In pregnancy, TNF-α influences hormone synthesis, placental architecture, and embryonic development.
K. Romanowska-Próchnicka, A. Felis-Giemza, M. Olesińska, Piotr Wojdasiewicz, A. Paradowska-Gorycka, D. Szukiewicz   +5 more
semanticscholar   +1 more source

The role of IL-1β and TNF-α in intervertebral disc degeneration.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
Low back pain (LBP), a prevalent and costly disease around the world, is predominantly caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial burden to public health and the economy. IDD is mainly caused by aging, trauma,
Yongjie Wang, Ming-Xue Che, Jingguo Xin, Zhi Zheng, Jiang-Bin Li, Shao-Kun Zhang   +5 more
semanticscholar   +1 more source

Anti-TNF-α Compounds as a Treatment for Depression

Molecules, 2021
Millions of people around the world suffer from psychiatric illnesses, causing unbearable burden and immense distress to patients and their families. Accumulating evidence suggests that inflammation may contribute to the pathophysiology of psychiatric ...
Sarit Uzzan, A. Azab
semanticscholar   +1 more source

The dual role of tumor necrosis factor-alpha (TNF-α) in breast cancer: molecular insights and therapeutic approaches

Cellular Oncology, 2020
Breast cancer is the most prevalent cancer among women worldwide and the fifth cause of death among all cancer patients. Breast cancer development is driven by genetic and epigenetic alterations, with the tumor microenvironment (TME) playing an essential
Daniel Cruceriu, Oana Baldasici, O. Bălăcescu, I. Berindan-Neagoe   +3 more
semanticscholar   +1 more source

Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss

Acta Biomaterialia, 2020
Mesenchymal stem cell (MSC)–derived exosome plays a central role in the cell-free therapeutics involving MSCs and the contents can be customized under disease-associated microenvironments.
Yukihiro Nakao, T. Fukuda, Qun-Zhou Zhang, T. Sanui, T. Shinjo, X. Kou, Chider Chen, Da-Wei Liu, Yukari Watanabe, Chikako Hayashi, Hiroaki Yamato, Karen Yotsumoto, Urara Tanaka, T. Taketomi, T. Uchiumi, A. Le, S. Shi, F. Nishimura   +17 more
semanticscholar   +1 more source

Correlation Between TNF- α and Degree of Gastritis

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2018
Background: TNF- α is a cytokine that plays an active role in the pathogenesis of gastritis. The correlation of TNF-α levels in the gastric mucosa with the severity of gastritis has long been known.
Ricky Rivalino, Darmadi, Gontar Alamsyah Siregar   +2 more
doaj   +1 more source

Impact of TNF-α Inhibitors on Body Weight and BMI: A Systematic Review and Meta-Analysis

Frontiers in Pharmacology, 2020
ObjectiveThe aim of this systematic review and meta-analysis of longitudinal studies was to ascertain to effects of TNF-α inhibitor therapy on body weight and BMI.MethodsThree databases (PubMed, OVID, and EMBASE) were systematically searched from ...
Olivia Patsalos, Bethan Dalton, Jenni Leppanen, Mohammad A. A. Ibrahim, Hubertus Himmerich   +4 more
doaj   +1 more source