Results 31 to 40 of about 1,383,229 (318)

Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activation and apoptosis in oxygen–glucose deprived cultured cortical cells

Neurobiology of Disease, 2009
TNF-α has been reported to be relevant in stroke-induced neuronal death. However the precise function of TNF-α in brain ischemia remains controversial since there are data supporting either a detrimental or a protective effect. Here we show that TNF-α is
Nahuai Badiola, Cristina Malagelada, Nuria Llecha, Juan Hidalgo, Joan X. Comella, Josefa Sabriá, José Rodríguez-Alvarez   +6 more
doaj   +1 more source

Inhibition of Akt phosphorylation attenuates resistance to TNF-α cytotoxic effects in MCF-7 cells, but not in their doxorubicin resistant derivatives [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Acquisition of TNF-α resistance plays role in the onset and growth of malignant tumors. Previous studies have demonstrated that MCF-7 cell line and its doxorubicin resistant variant MCF-7/Adr are resistant against the cytotoxic effects of ...
Morteza Ghandadi, Atieh Mohammadi, Javad Behravan, Khalil Abnous, Negin Haj-Ali, Melika Ehtesham Gharaee, Fatemeh Mosaffa   +6 more
doaj   +1 more source

TNF‐α polymorphisms affect persistence and progression of HBV infection

Molecular Genetics & Genomic Medicine, 2019
Background Hepatitis B virus (HBV) infections are a major threat worldwide. Disease progression and outcome is diverse and depends on host genetic background. Recently, a high rate of HBV reactivation in individuals receiving tumor necrosis factor‐α (TNF‐
Anna Woziwodzka, Magda Rybicka, Alicja Sznarkowska, Tomasz Romanowski, Marcin Dręczewski, Piotr Stalke, Krzysztof Piotr Bielawski   +6 more
doaj   +1 more source

The expression of TNF-α, IL-1β, and IL-10 in the diabetes mellitus condition induced by the combination of spirulina and chitosan

Bali Medical Journal, 2020
Background: Rapid wound healing is needed after tooth extraction treatment so that prosthodontics treatment can be done immediately. However, systemic diseases, such as diabetes mellitus, can inhibit the wound healing process. The state of hyperglycemia in people with diabetes mellitus can interfere with the function of macrophages and neutrophils ...
Nike Hendrijantini, -, Ratri Maya Sitalaksmi, -, Muhammad Dimas Aditya Ari, -, Tiffany Josephine Hidayat, -, Prisca Agustina Nurcahyani Putri, -, Daniel Sukandar, -   +5 more
openaire   +1 more source

TNF-α Differentially Regulates Cell Cycle Genes in Promyelocytic and Granulocytic HL-60/S4 Cells

G3: Genes, Genomes, Genetics, 2019
Tumor necrosis factor alpha (TNF-α) is a potent cytokine involved in systemic inflammation and immune modulation. Signaling responses that involve TNF-α are context dependent and capable of stimulating pathways promoting both cell death and survival. TNF-
Elsie C. Jacobson, Lekha Jain, Mark H. Vickers, Ada L. Olins, Donald E. Olins, Jo K. Perry, Justin M. O’Sullivan   +6 more
doaj   +1 more source

Regulatory T cells in Crohn's disease following anti‐TNF‐α therapy

JGH Open, 2020
Background and Aim Anti‐tumor necrosis factor alpha (TNF‐α) therapy is an effective therapy for Crohn's disease (CD). We investigated FoxP3+ and CD127− regulatory T cells (Tregs) before and after administration of anti‐TNF‐α therapy in CD.
Toshimi Chiba, Mikiya Endo, Shoko Miura, Yuko Hayashi, Yoshiko Asakura, Kotaro Oyama, Takayuki Matsumoto   +6 more
doaj   +1 more source

The TNF-α-308G/A Gene Polymorphism and Serum TNF-α Levels in Women With Preeclampsia

Journal of Family and Reproductive Health, 2022
Objective: Worldwide, preeclampsia (PE) is a multifactorial disorder reported in 2–5% of pregnancies, which increases mortality during pregnancy. In general, 10–15% of maternal deaths are directly related to PE and eclampsia.
Allahdad Khodadadi, Ata Ghadiri, Mehri Ghafourian, Sara Iranparast, Mahin Najafian   +4 more
doaj   +1 more source

TNF-α in Uveitis: From Bench to Clinic

Frontiers in Pharmacology, 2021
Uveitis is an inflammation of the iris, ciliary body, vitreous, retina, or choroid, which has been shown to be the first manifestation of numerous systemic diseases.
Qi Jiang, Zhaohuai Li, Tianyu Tao, Runping Duan, Xianggui Wang, Xianggui Wang, Wenru Su   +6 more
doaj   +1 more source

Effect of Artemisia fruit extract on TNF- α and IL-6 levels in streptozotocin-induced diabetic mice

Journal of Contemporary Medical Sciences, 2019
Objective: The present study was conducted to investigate the effects of Artemisia extract on some immunological parameters in streptozotocin-induced diabetic mice. Methods: After preparation of Artemisia extract, many chemical tests were used to identify the type of element and compounds presented in this plant using many chemical techniques ...
Ekhlass N. Ali, Emad Mahmoud Eltyeaf, Ashwaq A. Kadhem, Jamela Jouda   +3 more
openaire   +2 more sources

Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers [PDF]

, 2003
Objectives: Our study sought to elucidate the role of oxidative stress for shedding of tumor necrosis factor-α (TNF-α) and for activating TNF-α-converting enzyme (TACE).
Welsch, Ulrich, Sommerhoff, Christian P., Gilles, Stefanie, Zahler, Stefan, Becker, Bernhard F.   +4 more
core   +1 more source