Results 21 to 30 of about 1,312 (166)

An overview of the past decade of bufalin in the treatment of refractory and drug-resistant cancers: current status, challenges, and future perspectives

Frontiers in Pharmacology, 2023
Profound progress has been made in cancer treatment in the past three decades. However, drug resistance remains prevalent and a critical challenge.
Qingmei Ye, Qingmei Ye, Xin Zhou, Han Ren, Fangxuan Han, Rong Lin, Juan Li   +6 more
doaj   +1 more source

Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads

Molecules, 2022
Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000 years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of amphibians and toads and can also be extracted from natural products such ...
Hesham R. El-Seedi, Nermeen Yosri, Bishoy El-Aarag, Shaymaa H. Mahmoud, Ahmed Zayed, Ming Du, Aamer Saeed, Syed G. Musharraf, Islam M. El-Garawani, Mohamed R. Habib, Haroon Elrasheid Tahir, Momtaz M. Hegab, Xiaobo Zou, Zhiming Guo, Thomas Efferth, Shaden A. M. Khalifa   +15 more
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Clinical and electrocardiographic evaluation during experimental toad poisoning in dogs

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
Accidents involving toad poisoning are frequent and dogs are the most common victims; they become poisoned by biting or ingesting a toad. When released in the organism, the venom is absorbed by both the oral mucosa and the digestive tract, initiating its
AC Camplesi, M Sakate, NMB Simão, R Marucio, FCD Mota, CF Moya-Araujo   +5 more
doaj   +1 more source

Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides

Molecules, 2021
Toad venom contains a large number of bufadienolides, which have a variety of pharmacological activities, including antitumor, cardiovascular, anti-inflammatory, analgesic and immunomodulatory effects.
Huili Shao, Bingqian Li, Huan Li, Lei Gao, Chao Zhang, Huagang Sheng, Liqiao Zhu   +6 more
doaj   +1 more source

Comparative Analysis of the Bufonis Venenum by Using TLC, HPLC, and LC-MS for Different Extraction Methods

Journal of Pharmacopuncture, 2012
Objectives: Toad venom, called Chan-Su, is a traditional Oriental medicine secreted from the auricular and the skin glands of the Bufo bufo gargarizanz Cantor or B.
Lee Hyo-Jae , Koung Fan-Pei, Kwon Ki-Rok, Kang Dae-In, Cohen Lorenzo, Yang Pei-Ying , Yoo Hwa-Seung   +6 more
doaj   +1 more source

Intoxicação por veneno de sapo em um canino Toad venom intoxication in a dog

Ciência Rural, 2008
O sapo do gênero Bufo possui nas suas glândulas paratóides uma secreção mucóide contendo toxinas como bufaginas e Bufotoxinas, que são esteróides cardiogênicos. Os cães podem atacar os sapos, entrando em contato com o veneno por meio das mucosas.
Luciana Sonne, Daniela Bernadete Rozza, Adriana Nunes Wolffenbüttel, Adriana Erica Wilkes Burton Meirelles, Pedro Miguel Ocampos Pedroso, Eduardo Conceição de Oliveira, David Driemeier   +6 more
doaj   +1 more source

Toad poisoning in three dogs: case reports

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
Toad poisoning is frequent in dogs, but has been infrequently addressed in published case reports and review articles. Dogs can be poisoned when they bite a toad or otherwise ingest the venom. The venom effects manifest soon after the accident, since the
CM Barbosa, MS Medeiros, CCM Riani Costa, AC Camplesi, M. Sakate   +4 more
doaj   +1 more source

Uncovering the antimalarial potential of toad venoms through a bioassay-guided fractionation process

International Journal for Parasitology: Drugs and Drug Resistance, 2022
Malaria remains to date one of the most devastating parasitic diseases worldwide. The fight against this disease is rendered more difficult by the emergence and spread of drug-resistant strains. The need for new therapeutic candidates is now greater than
Mathilde Wells, Mathieu Fossépré, Stéphanie Hambye, Mathieu Surin, Bertrand Blankert   +4 more
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Chromatographic study of toad venoms for taxonomic purposes [PDF]

Bolletino di zoologia, 1989
Abstract The secretion of the parotoid glands of six species of toads of the genus Bufo has been analysed with circular chromatograpy. From the resulting bands a ≪dissimilarity matrix≫ was constructed. The numerical data, derived from a computer program, yielded a den drogram of the evolution of the analysed secretion that fits well with dendrograms ...
Giovanni Ceriotti, Pietro Cardellini, Paola Marian, Mario Sala   +3 more
openaire   +1 more source

Miniaturized Bioaffinity Assessment Coupled to Mass Spectrometry for Guided Purification of Bioactives from Toad and Cone Snail

Biology, 2014
A nano-flow high-resolution screening platform, featuring a parallel chip-based microfluidic bioassay and mass spectrometry coupled to nano-liquid chromatography, was applied to screen animal venoms for nicotinic acetylcholine receptor like (nAChR ...
Ferry Heus, Reka A. Otvos, Ruud L. E. G. Aspers, Rene van Elk, Jenny I. Halff, Andreas W. Ehlers, Sébastien Dutertre, Richard J. Lewis, Sybren Wijmenga, August B. Smit, Wilfried M. A. Niessen, Jeroen Kool   +11 more
doaj   +1 more source