Results 51 to 60 of about 1,312 (166)

Bufarenogin induces intrinsic apoptosis via Bax and ANT cooperation

Pharmacology Research & Perspectives, 2021
Toads have high medicinal value and have been used for medicinal purposes since the Tang Dynasty period (7th‐10th Century AD). Bufarenogin, an active anti‐tumor constituent of toad venom, shows anti‐tumor activity.
Qinrui Han, Chun Zhang, Yongbin Zhang, Yuan Li, Liyi Wu, Xuegang Sun   +5 more
doaj   +1 more source

Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway

Pharmaceutical Biology, 2022
Context Acute promyelocytic leukaemia (APL) is a malignant hematological tumour characterized by the presence of promyelocytic leukaemia–retinoic acid receptor A (PML-RARA) fusion protein. Cinobufagin (CBG) is one of the main effective components of toad
Yaoyao Bian, Mei Xue, Xinlong Guo, Wenjuan Jiang, Ye Zhao, Zhaofeng Zhang, Xian Wang, Yongkang Hu, Qi Zhang, Wenliang Dun, Liang Zhang   +10 more
doaj   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, Volume 13, Issue 16, 18 March 2026.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Community‐level effects of Müllerian mimicry on pollinator diversity and functioning

Functional Ecology, Volume 40, Issue 3, Page 599-610, March 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Müllerian mimicry, a mutualistic interaction in which harmful species evolve similar warning signals, is often accompanied by niche divergence among mimetic species. While these aspects have traditionally been studied in an evolutionary context, their community‐level ...
Paola Laiolo, José Ramón Obeso
wiley   +1 more source

New Diagnoses Cover Venomous Toads and Exploding Spacecrafts [PDF]

Primary Health Care: Open Access, 2014
Many of us are shaking our heads as another deadline looms for health care reform (exhibiting diagnostic code Z734, inadequate social skills not elsewhere classified). October 1, 2015, is the newest date for conversion to a new classification for diseases used by virtually all medical practices for billing purposes.
openaire   +1 more source

The Influence of Climate and Livestock Grazing on Two Species of Burrowing Desert Frogs

Austral Ecology, Volume 51, Issue 3, March 2026.
ABSTRACT Frogs are one of the most vulnerable groups of vertebrates globally, occupying a range of environments including arid deserts. They are threatened by many interacting factors, including climate change and livestock grazing. In this study, we present the first long‐term research (over 30 years) on two arid‐dwelling frogs in Australia, the ...
R. J. Cairncross, G. M. Wardle, C. R. Dickman   +2 more
wiley   +1 more source

We Licked the Toads so You Don’t Have to: A Comprehensive Analysis of the Chemical Syntheses of the Classical Psychedelics Bufotenin(e) and 5‐Methoxy‐N,N‐Dimethyltryptamine

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
The psychedelics 5‐MeO‐DMT and bufotenin—famously secreted by some toads—have been made in many different ways since 1936. Bufotenin (also spelt as bufotenine) and its methylated derivative, 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT), are potent psychedelics that are found in many plants but also excreted by some species of toads.
Anton Homon, Jaxon Laramie, John J. Hayward, John F. Trant   +3 more
wiley   +1 more source

Securing Generative Artificial Intelligence with Parallel Magnetic Tunnel Junction True Randomness

Advanced Intelligent Systems, Volume 8, Issue 2, February 2026.
True random numbers can protect generative artificial intelligence (GAI) models from attacks. A highly parallel, spin‐transfer torque magnetic tunnel junction‐based system is demonstrated that generates high‐quality, energy‐efficient random numbers.
Youwei Bao, Shuhan Yang, Hyunsoo Yang
wiley   +1 more source

Antiplasmodial and Cytotoxic Activities of Toad Venoms from Southern Amazon, Brazil [PDF]

The Korean Journal of Parasitology, 2016
The drug-resistance of malaria parasites is the main problem in the disease control. The huge Brazilian biodiversity promotes the search for new compounds, where the animal kingdom is proving to be a promising source of bioactive compounds. The main objective of this study was to evaluate the antiplasmodial and cytotoxic activity of the compounds ...
Banfi, Felipe Finger, Guedes, Karla de Sena, Andrighetti, Carla Regina, Aguiar, Ana Carolina, Debiasi, Bryan Wender, Noronha, Janaina da Costa, Rodrigues, Domingos de Jesus, Júnior, Gerardo Magela Vieira, Sanchez, Bruno Antonio Marinho   +8 more
openaire   +2 more sources