Results 71 to 80 of about 4,151 (204)

Advancement in research of anti-cancer effects of toad venom (ChanSu) and perspectives

World Journal of Traditional Chinese Medicine, 2015
Toad venom, called as ChanSu in China, is a widely used traditional Chinese medicine (TCM) whose active components are mainly bufadienolides. ChanSu could exhibit cardiotonic, anti-microbial, anti-inflammatory and, most importantly, anti-cancer effects ...
Miao Liu, Li-Xing Feng, Li-Hong Hu, Xuan Liu, De-An Guo   +4 more
doaj   +1 more source

Histological Study of Glandular Variability in the Skin of the Natterjack Toad—Epidalea calamita (Laurenti, 1768)—Used in Spanish Historical Ethnoveterinary Medicine and Ethnomedicine

Veterinary Sciences, 2022
Common toads have been used since ancient times for remedies and thus constitute excellent biological material for pharmacological and natural product research. According to the results of a previous analysis of the therapeutic use of amphibians in Spain,
José Ramón Vallejo, José A. González, María Eugenia Gómez-Navarro, José María López-Cepero   +3 more
doaj   +1 more source

A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (+/-)-xenovenine [PDF]

, 2013
Total syntheses of alkaloid cis-223B and xenovenine are reported in 3 and 4 steps respectively using a two-directional synthesis/triple reductive amination strategy, and their neurotoxic properties ...
Alexandre Barthelme, Arredondo, Asano, Ayer, Badio, Brior, Daly, David Richards, Garraffo, Gignoux, Ian R. Mellor, Jiang, Jones, Jones, King, Lathbury, Legeay, Liddell, Liu, Narberhaus, Newton, Prakash, Robbins, Robert A. Stockman, Roe, Schmeller, Takahata, Takahata, Toyooka, Toyooka, Tsuneki, Tursch, Tursch, Wang   +33 more
core   +2 more sources

The impacts of biological invasions

Biological Reviews, Volume 101, Issue 3, Page 1255-1310, June 2026.
ABSTRACT The Anthropocene is characterised by a continuous human‐mediated reshuffling of the distributions of species globally. Both intentional and unintentional introductions have resulted in numerous species being translocated beyond their native ranges, often leading to their establishment and subsequent spread – a process referred to as biological
Phillip J. Haubrock, Teun Everts, Neil Angelo S. Abreo, Jamie Bojko, Victor Deklerck, James W. E. Dickey, Ana Clara S. Franco, Emili García‐Berthou, Stelios Katsanevakis, Natalia I. Kirichenko, Stefano Mammola, Martin A. Nuñez, Ben Parker, Riccardo Scalera, Ismael Soto, Diederik Strubbe, Ali Serhan Tarkan, Lorenzo Vilizzi, Tim Adriaens, Paride Balzani, Dagmara Błońska, Elizabeta Briski, Rein Brys, Amy L. Burgess, James E. Byers, Carlos Cano‐Barbacil, Giuseppe Castaldelli, Jaimie T.A. Dick, Victoria Dominguez Almela, Romina D. Dimarco, Margarita Florencio, Antonín Kouba, Melina Kourantidou, Irmak Kurtul, Irene Martín‐Forés, Olivier Morissette, Julian D. Olden, Bruno E. Soares, Jakub Truszkowski, Hugo Verreycken, Marc Kenis, Ronaldo Sousa, J. Robert Britton   +42 more
wiley   +1 more source

Bufarenogin induces intrinsic apoptosis via Bax and ANT cooperation

Pharmacology Research & Perspectives, 2021
Toads have high medicinal value and have been used for medicinal purposes since the Tang Dynasty period (7th‐10th Century AD). Bufarenogin, an active anti‐tumor constituent of toad venom, shows anti‐tumor activity.
Qinrui Han, Chun Zhang, Yongbin Zhang, Yuan Li, Liyi Wu, Xuegang Sun   +5 more
doaj   +1 more source

Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway

Pharmaceutical Biology, 2022
Context Acute promyelocytic leukaemia (APL) is a malignant hematological tumour characterized by the presence of promyelocytic leukaemia–retinoic acid receptor A (PML-RARA) fusion protein. Cinobufagin (CBG) is one of the main effective components of toad
Yaoyao Bian, Mei Xue, Xinlong Guo, Wenjuan Jiang, Ye Zhao, Zhaofeng Zhang, Xian Wang, Yongkang Hu, Qi Zhang, Wenliang Dun, Liang Zhang   +10 more
doaj   +1 more source

Helmeted hornbill cranial kinesis: Balancing mobility and stability in a high‐impact joint

The Anatomical Record, Volume 309, Issue 5, Page 1299-1312, May 2026.
Abstract Prokinesis—in which a craniofacial joint allows the rostrum to move relative to the braincase—is thought to confer diverse advantages in birds, mostly for feeding. A craniofacial joint would, however, be a weak link if cranial stability is important. Paradoxically, we have identified a craniofacial joint in helmeted hornbills (Rhinoplax vigil),
Mike Schindler, Benjamin Flaum, Armita Razieh Manafzadeh, Viktoriia Kamska, Kanmani Chandra Rajan, Maria Jose Robles Malagamba, Ruien Hu, Daniel Baum, Mason N. Dean   +8 more
wiley   +1 more source

Hypotheses for the Adaptive Maintenance of Phenotypic Polymorphisms

Ecology and Evolution, Volume 16, Issue 5, May 2026.
Phenotypic polymorphisms offer easily observable diversity ideal for empirical and theoretical exploration, but developing and comparing hypotheses for the adaptive maintenance of polymorphism can be a challenge. Here, we propose a framework categorizing polymorphisms based on (i) one of five distinct types of maintenance selection and (ii) the context
Jay J. Falk, Michael S. Webster, Dustin R. Rubenstein   +2 more
wiley   +1 more source

Population‐Level Laterality of Ambush Posture in the Chinese Green Tree Pit Viper (Trimeresurus stejnegeri) in Northern Taiwan

Ecology and Evolution, Volume 16, Issue 5, May 2026.
In the Chinese green tree pit viper (Trimeresurus stejnegeri), we tested whether ambush posture shows population‐level laterality using 283 photographic records from nocturnal field surveys and verified iNaturalist observations across three regions in northern Taiwan.
Hung‐Chia Chang, Si‐Min Lin
wiley   +1 more source

Telecological Collapse: The Inevitability of Climate Breakdown in the Transmedial Podcast Drama Forest 404

Future Humanities, Volume 4, Issue 1, May 2026.
ABSTRACT This paper presents a close‐hearing analysis of Forest 404, a transmedial audio drama that was released to BBC Sounds in 2019. Despite the drama's eco‐dystopian critique of teleological ‘progress’ narratives (that enable and perpetuate the destruction of the natural world), I argue that the series ultimately propagates a sense of inevitability
Matilda Jones
wiley   +1 more source