Results 11 to 20 of about 10,905 (230)
Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket-Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target. [PDF]
Adv Sci (Weinh)Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Ding X +15 more
europepmc +2 more sources
Vaccine development for mosquito-borne viral diseases
Frontiers in Immunology, 2023 Mosquito-borne viral diseases are a group of viral illnesses that are predominantly transmitted by mosquitoes, including viruses from the Togaviridae and Flaviviridae families.
Zhiwei Huang +7 more
doaj +1 more source
An Unusual Case of Myelitis with Myositis [PDF]
Journal of Clinical and Diagnostic Research, 2016 The Chikungunya virus belonging to genus alphavirus and family togaviridae causes an arthropod-borne self-limiting febrile illness in humans. Neurological complications are rare with myelitis being even a rarer presentation.
Neera Choudhary +4 more
doaj +1 more source
Epidemic Alphaviruses: Ecology, Emergence and Outbreaks
Microorganisms, 2020 Over the past century, the emergence/reemergence of arthropod-borne zoonotic agents has been a growing public health concern. In particular, agents from the genus Alphavirus pose a significant risk to both animal and human health.
Sasha R. Azar +4 more
doaj +1 more source
Multiple interferon stimulated genes synergize with the zinc finger antiviral protein to mediate anti-alphavirus activity. [PDF]
PLoS ONE, 2012 The zinc finger antiviral protein (ZAP) is a host factor that mediates inhibition of viruses in the Filoviridae, Retroviridae and Togaviridae families.
Sophiya Karki +5 more
doaj +1 more source
A mini-review on sofosbuvir and daclatasvir treatment in coronavirus disease 2019
New Microbes and New Infections, 2021 Sofosbuvir and daclatasvir have been used successfully since 2013 for hepatitis C treatment. It has been shown by different studies that sofosbuvir can inhibit RNA polymerase of other positive-strand RNA viruses including Flaviviridae and Togaviridae ...
M. Shabani +3 more
doaj +1 more source