Results 61 to 70 of about 6,334 (187)

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

First Phosphonic‐Type Inhibitors and Activity‐Based Probes Specific to the O'nyong‐nyong Virus Capsid Protease

ChemMedChem, Volume 20, Issue 12, June 17, 2025.
The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska, Agnieszka Łupicka‐Słowik, Renata Grzywa, Yuliya Chykunova, Krzysztof Pyrć, Marcin Sieńczyk   +5 more
wiley   +1 more source

Seroprevalence of antibodies to Venezuelan equine encephalitis complex (subtypes IAB and VI) in humans from General Belgrano Island, Formosa, Argentina

Revista do Instituto de Medicina Tropical de São Paulo, 2003
This work presents the results of the detection of antibodies (immunoglobulin G) for subtypes I and VI of VEE viruses complex (Togaviridae family) in people from the General Belgrano island, Formosa province (Argentina).
Cámara Alicia, Díaz Gladis, Vega Victor, Basualdo María, Contigiani Marta   +4 more
doaj  

Mosquito‐Borne Diseases in Canada: Integrated Perspectives on Disease Management and Influences of Environmental and Anthropogenic Factors Affecting the Transmission Cycle

Public Health Challenges, Volume 4, Issue 2, June 2025.
ABSTRACT Globally, mosquito‐borne diseases (MBD) cause the highest morbidity and mortality in humans and animals. Currently, in Canada, endemic MBDs that are significant public health problems are all zoonoses and are caused primarily by West Nile virus, Eastern equine encephalitis virus, and Californian serogroup viruses, including the Jamestown ...
Antoinette Ludwig, David Lapen
wiley   +1 more source

Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition

The FEBS Journal, Volume 292, Issue 11, Page 2865-2881, June 2025.
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda, Karine Alvarez, Benjamin Morin, Bruno Canard, François Ferron, Nadia Rabah   +5 more
wiley   +1 more source

The Journey of in vivo Virus Engineered Dendritic Cells From Bench to Bedside: A Bumpy Road

Frontiers in Immunology, 2018
Dendritic cells (DCs) are recognized as highly potent antigen-presenting cells that are able to stimulate cytotoxic T lymphocyte (CTL) responses with antitumor activity.
Cleo Goyvaerts, Karine Breckpot
doaj   +1 more source

The Mayaro virus and its potential epidemiological consequences in Colombia: an exploratory biomathematics analysis

Parasites & Vectors, 2020
Background Mayaro virus (Togaviridae) is an endemic arbovirus of the Americas with epidemiological similarities with the agents of other more prominent diseases such as dengue (Flaviviridae), Zika (Flaviviridae), and chikungunya (Togaviridae).
Bryan Steven Valencia-Marín, Irene Duarte Gandica, Oscar Alexander Aguirre-Obando   +2 more
doaj   +1 more source

Silver Nanoparticle‐Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review

Global Challenges, Volume 9, Issue 5, May 2025.
Silver nanoparticles (AgNPs) exhibit broad‐spectrum antiviral activity by targeting key viral structures and processes. They disrupt viral envelopes, compromising integrity, and bind to nucleocapsids, impairing viral replication. AgNPs also inhibit glycoprotein interactions, preventing viral attachment and entry into host cells.
Ekaterine Mosidze, Gianluigi Franci, Federica Dell'Annunziata, Nicoletta Capuano, Marica Colella, Flora Salzano, Massimiliano Galdiero, Aliosha Bakuridze, Veronica Folliero   +8 more
wiley   +1 more source

The Aedes aegypti Domino Ortholog p400 Regulates Antiviral Exogenous Small Interfering RNA Pathway Activity and ago-2 Expression

mSphere, 2020
Arboviruses are pathogens of humans and animals. A better understanding of the interactions between these pathogens and the arthropod vectors, such as mosquitoes, that transmit them is necessary to develop novel control measures.
Melanie McFarlane, Floriane Almire, Joy Kean, Claire L. Donald, Alma McDonald, Bryan Wee, Mathilde Lauréti, Margus Varjak, Sandra Terry, Marie Vazeille, Rommel J. Gestuveo, Isabelle Dietrich, Colin Loney, Anna-Bella Failloux, Esther Schnettler, Emilie Pondeville, Alain Kohl   +16 more
doaj   +1 more source

Alphavirus nsP2: A Multifunctional Regulator of Viral Replication and Promising Target for Anti‐Alphavirus Therapies

Reviews in Medical Virology, Volume 35, Issue 2, March 2025.
ABSTRACT Alphaviruses are re‐emerging vector‐born pathogens that cause arthralgia or encephalitic diseases on a global scale. While a vaccine against chikungunya virus was recently approved, no vaccines currently exist for other alphaviruses, nor are there antiviral drugs for the treatment of alphavirus infections. Alphaviruses have positive‐strand RNA
Sainan Wang, Suresh Mahalingam, Andres Merits   +2 more
wiley   +1 more source