Results 141 to 150 of about 7,251 (175)

Quercetin Enhances the Antibacterial Activity of Polymyxin E Against MCR-1-Positive Bacteria by Inhibiting the Biological Functions of the Cell Membrane. [PDF]

Animals (Basel)
Zhang Y, Guo L, Wang S, Zhang J, Ren X, Li R, Li J, Chen C.   +7 more
europepmc   +1 more source

Strain-dependent contribution of the AcrAB-TolC efflux pump to Klebsiella pneumoniae physiology

Bhogal K, Clough B, Emmerson C, Organ A, Chen Y, Buckner MM, Alav I.   +6 more
europepmc   +1 more source

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Lpp positions peptidoglycan at the AcrA-TolC interface in the AcrAB-TolC multidrug efflux pump

Biophysical Journal, 2021
The multidrug efflux pumps of Gram-negative bacteria are a class of complexes that span the periplasm, coupling both the inner and outer membranes to expel toxic molecules. The best-characterized example of these tripartite pumps is the AcrAB-TolC complex of Escherichia coli.
James C, Gumbart, Josie L, Ferreira, Hyea, Hwang, Anthony J, Hazel, Connor J, Cooper, Jerry M, Parks, Jeremy C, Smith, Helen I, Zgurskaya, Morgan, Beeby   +8 more
openaire   +2 more sources

The tip region of the MacA α-hairpin is important for the binding to TolC to the Escherichia coli MacAB–TolC pump

Biochemical and Biophysical Research Communications, 2010
The tripartite efflux pump MacAB-TolC found in gram-negative bacteria is involved in resistance to antibiotics. We previously reported the funnel-like hexameric structure of the adaptor protein MacA to be physiologically relevant. In this study, we investigated the role of the tip region of its alpha-hairpin, which forms a cogwheel structure in the ...
Saemee Song, Kangseok Lee, Nam-Chul Ha   +2 more
exaly   +3 more sources

Detergent headgroups control TolC folding in vitro

Biophysical Journal, 2023
TolC is the trimeric outer membrane component of the efflux pump system in Escherichia coli that is responsible for antibiotic efflux from bacterial cells. Overexpression of efflux pumps has been reported to decrease susceptibility to antibiotics in a variety of bacterial pathogens.
Ayotunde Paul Ikujuni, S. Jimmy Budiardjo, Rik Dhar, Joanna S.G. Slusky   +3 more
openaire   +2 more sources

Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12

Applied and Environmental Microbiology, 2021
Antibiotics and other drugs that reach the gut must pass through stomach acid. However, little is known of how extreme acid modulates the effect of drugs on gut bacteria.
Katarina M Bischof, Joan L Slonczewski
exaly   +4 more sources

Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae [PDF]

Research in Microbiology, 2018
Bacterial multidrug efflux systems are a major mechanism of antimicrobial resistance and are fundamental to the physiology of Gram-negative bacteria. The resistance-nodulation-division (RND) family of efflux pumps is the most clinically significant, as it is associated with multidrug resistance.
Vito Ricci, Laura J V Piddock
exaly   +3 more sources

Vibrio cholerae TolC Is Required for Expression of the ToxR Regulon

Infection and Immunity, 2021
Vibrio cholerae is a Gram-negative bacterium that causes the enteric disease cholera. V. cholerae colonization of the human intestine is dependent on the expression of both virulence genes and environmental adaptation genes involved in antimicrobial resistance.
Yuding Weng, Edith G. Fields, Thomas F. Bina, James A. Budnick, Dillon E. Kunkle, X. Renee Bina, James E. Bina   +6 more
openaire   +2 more sources