Results 71 to 80 of about 10,453,112 (207)

A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Advanced Science, EarlyView.
A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao, Yufei Lan, Min‐Goo Lee, Jinjun He, Yueran Pan, Eunji Kim, Xin Fu, Sungwook Jung, Wanxia Lu, Jinyue Fan, Haoxiang Chen, Yuanbo Zhao, Yuling Xu, Jong Seung Kim, Chao Zhang   +14 more
wiley   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Upper Iowa University campus, 1908

, 1908
Two photographic views of campus. Top view is taken looking uphill from the west. Left to right: (some buildings behind trees) are Science Hall [no longer exists; now location of Colgrove-Walker]; Main Building [now Alexander-Dickman]; Ladies Hall [no ...
Upper Iowa University
core   +1 more source

ERICA: intake of macro and micronutrients of Brazilian adolescents

Revista de Saúde Pública, 2016
OBJECTIVE To describe food and macronutrient intake profile and estimate the prevalence of inadequate micronutrient intake of Brazilian adolescents.
Amanda de Moura Souza, Laura Augusta Barufaldi, Gabriela de Azevedo Abreu, Denise Tavares Giannini, Cecília Lacroix de Oliveira, Marize Melo dos Santos, Vanessa Sá Leal, Francisco de Assis Guedes Vasconcelos   +7 more
doaj   +4 more sources

Dietary minerals intake by lactating women in three cities of China and comparison with Chinese Dietary Reference Intakes (estimated average requirement, EAR; recommended nutrient intake, RNI; adequate intake, AI, tolerable upper intake level, UL and proposed intakes for preventing non-communicable chronic disease, PI-NCD; N = 468).

, 2016
Dietary minerals intake by lactating women in three cities of China and comparison with Chinese Dietary Reference Intakes (estimated average requirement, EAR; recommended nutrient intake, RNI; adequate intake, AI, tolerable upper intake level, UL and ...
Yong Xue (307664), Peiyu Wang (398406), Yumei Zhang (415982), Wenjun Li (41954), Ai Zhao (650312), Kai Yu (50223)   +5 more
core   +1 more source

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

Advanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma, Lingyun He, Xinru Wang, Yuanyuan Wei, Chengcheng Li, Jiaqi Yan, Weijian Sun, Xian Shen, Hongbo Zhang   +8 more
wiley   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Are low tolerable upper intake levels for vitamin A undermining effective food fortification efforts? [PDF]

, 2008
Vitamin A deficiency (VAD) is a major health problem, particularly in low-resource countries, putting an estimated 125-130 million preschool-aged children at increased risk of morbidity and mortality from infectious diseases.
Waelti, Monika, Moench-Pfanner, Regina, Kraemer, Klaus, De Pee, Saskia, Bloem, Martin W, Hathcock, John N, Semba, Richard D   +6 more
core   +1 more source

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

Food and nutrient intake in pregnant women with singletons or multiples and post-delivery changes in intake in Korea: an observational study [PDF]

Korean Journal of Community Nutrition
Objectives Nutrient intake during pregnancy and lactation is crucial for the health of both mother and offspring. Diet and nutrient metabolism potentially vary according to ethnicity and fetal number; nevertheless, recent studies validating this are ...
Cheawon Lee, Dahyeon Kim, Yoon Ha Kim, Myeong Gyun Choi, Jong Woon Kim, Clara Yongjoo Park   +5 more
doaj   +1 more source