Results 81 to 90 of about 9,068 (239)

Effect of esomeprazole on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader, in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this study is to evaluate the effects of multiple doses of esomeprazole, a strong proton pump inhibitor and acid‐reducing agent, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader.
Lana Tran, Naihan Chen, Jennifer A. Winton, Kyle T. Matschke, Smita P. Goodman, Kimberly C. Lee, Yuanyuan Zhang, Weiwei Tan   +7 more
wiley   +1 more source

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

ERICA: intake of macro and micronutrients of Brazilian adolescents

Revista de Saúde Pública, 2016
OBJECTIVE To describe food and macronutrient intake profile and estimate the prevalence of inadequate micronutrient intake of Brazilian adolescents.
Amanda de Moura Souza, Laura Augusta Barufaldi, Gabriela de Azevedo Abreu, Denise Tavares Giannini, Cecília Lacroix de Oliveira, Marize Melo dos Santos, Vanessa Sá Leal, Francisco de Assis Guedes Vasconcelos   +7 more
doaj   +4 more sources

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

Tailoring drug‐to‐lipid ratio in redox‐responsive lipid‐mimetic prodrug liposomes for superior cabazitaxel delivery and antitumor efficacy

BMEMat, EarlyView.
Redox‐responsive lipid‐mimetic prodrug liposomes with high drug‐to‐lipid ratios enhance cabazitaxel delivery, prolong circulation, and enable tumor‐selective drug release for superior antitumor efficacy and safety. Abstract Liposomes represent one of the most extensively investigated nanocarriers in drug delivery.
Shengyao Xu, Danping Wang, Si Zheng, Zhiyu Kuang, Ya Gao, Haiyu Zhao, Lurong Zhang, Jiayu Guo, Jingyi Zhang, Weiyao Li, Anhua Wang, Hongrui Lei, Zhonggui He, Ken‐ichiro Kamei, Jianzhao Niu, Lingyun Ma, Bingjun Sun   +16 more
wiley   +1 more source

Do High Temperatures Affect Firm Demography? Evidence From Italy

Business Strategy and the Environment, EarlyView.
ABSTRACT This study analyses the impact of high temperatures and heat stress on Italian firm demography during 2009–2022. Combining provincial‐firm‐level data with a high‐resolution multidecadal meteorological dataset, we investigate whether high temperatures—absolute and anomalous—affect firm entry and exit rates.
Concetta Carnevale, Danilo Drago, Francesco Trivieri, Francesco De Simone   +3 more
wiley   +1 more source

Food and nutrient intake in pregnant women with singletons or multiples and post-delivery changes in intake in Korea: an observational study [PDF]

Korean Journal of Community Nutrition
Objectives Nutrient intake during pregnancy and lactation is crucial for the health of both mother and offspring. Diet and nutrient metabolism potentially vary according to ethnicity and fetal number; nevertheless, recent studies validating this are ...
Cheawon Lee, Dahyeon Kim, Yoon Ha Kim, Myeong Gyun Choi, Jong Woon Kim, Clara Yongjoo Park   +5 more
doaj   +1 more source

Knowledge Management and AI‐Driven Green Practices for Sustainable Performance

Business Strategy and the Environment, EarlyView.
ABSTRACT Organizations increasingly face strategic pressure to translate sustainability‐oriented knowledge and digital transformation initiatives into measurable environmental and organizational outcomes. In response, this study investigates how green knowledge management (GKM) contributes to sustainable business performance through the organizational ...
Hafiz Mudassir Rehman, Sofiane Laradi, Sandra Moffett, Amina Elfekair   +3 more
wiley   +1 more source

Safety of trimagnesium dicitrate anhydrous (TMDC) to be used as a food additive in food supplements in solid and chewable forms

EFSA Journal, 2016
The present scientific opinion deals with the safety of trimagnesium dicitrate anhydrous (TMDC) when used as a stabiliser and anticaking agent in food supplements in solid and chewable forms. TMDC is a magnesium salt of citric acid in the anhydrous form.
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), Alicja Mortensen, Fernando Aguilar, Riccardo Crebelli, Alessandro Di Domenico, Birgit Dusemund, Maria José Frutos, Pierre Galtier, Ursula Gundert‐Remy, Claude Lambré , Jean‐Charles Leblanc, Oliver Lindtner, Peter Moldeus, Pasquale Mosesso, Agneta Oskarsson, Dominique Parent‐Massin, Ivan Stankovic, Ine Waalkens‐Berendsen, Rudolf Antonius Woutersen, Matthew Wright, Maged Younes, Paul Tobback, Camilla Smeraldi, David Gott   +23 more
doaj   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source