Results 251 to 260 of about 202,194 (309)

Environmental specificity of tolerance

Trends in Neurosciences, 1984
In this article we summarize research which demonstrates that the display of tolerance is often more pronounced in the usual drug-administration environment than in an alternative environment. This environmental specificity of tolerance is consistent with a Parlovian conditioning model which suggests that tolerance is partially mediated bydrug ...
A.J. Goudie, J.W. Griffiths
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Tolerance to Liver‐Specific Antigens

Immunological Reviews, 1991
We have described a TG model for peripheral tolerance of alloreactive CTL. Expression of Q10/L on hepatocytes renders mice functionally tolerant, although in vitro we observe that TG animals have normal numbers of CTL.Pf directed against this antigen.
J, Forman, K, Wieties, R E, Hammer
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Subject-specific compressive tolerance estimates

Technology and Health Care, 2003
Spinal load models have become an increasingly valuable tool for the evaluation of the stress placed on the spine. In order to get an accurate representation of these spinal loads, they must be compared to known tolerance values. Bone mineral content and density of the lumbar spine of 23 males and 21 females was measured using a dual energy x-ray ...
K G, Davis, M, Parnianpour
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Engineering antigen-specific immunological tolerance

Current Opinion in Immunology, 2015
Unwanted immunity develops in response to many protein drugs, in autoimmunity, in allergy, and in transplantation. Approaches to induce immunological tolerance aim to either prevent these responses or reverse them after they have already taken place.
Stephan, Kontos, Alizée J, Grimm, Jeffrey A, Hubbell   +2 more
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Environment-specific tolerance to nicotine

Psychopharmacology, 1989
Research has shown that tolerance to the behavioral effects of numerous drugs is mediated by learning. The present study was designed to test whether animals develop tolerance to the antinociceptive effects of nicotine, and whether these effects are also learned. Rats were given dally injections of nicotine in the same environment. After each injection,
L H, Epstein, A R, Caggiula, R, Stiller
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Insulin-Specific Tolerance in Diabetes

Clinical Immunology, 2002
At present it is possible to predict the development of type 1A diabetes (immune-mediated diabetes) in man and prevent the disorder in animals. Studies of immunity to insulin play a prominent role in both disease prediction and disease prevention. For both man and the NOD mouse, insulin autoantibodies usually precede the development of diabetes and can
Peter A, Gottlieb, George S, Eisenbarth
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Achieving Antigen-Specific Tolerance in Diabetes: Regulating Specifically

International Reviews of Immunology, 2005
Autoreactive T cells that escape negative selection in the thymus do not normally cause productive immune responses to self-antigens because of a number of regulatory mechanisms. Studies with anti-CD3 monoclonal antibodies (mAbs) have suggested that immune regulatory mechanisms are induced by drug treatments that are able to stop on-going unwanted ...
Wei, Chen, Jeffrey A, Bluestone, Kevan C, Herold   +2 more
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Geometric Tolerance Specification

2011
In conventional tolerancing, the efforts of designers are mainly directed at selecting suitable values for linear tolerances on part dimensions. These are either determined by trial and error through analysis calculations or optimized according to cost functions.
ARMILLOTTA, ANTONIO, SEMERARO, QUIRICO
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Specific Transplantation Tolerance

New England Journal of Medicine, 1991
IN 1945 Ray Owen reported a remarkable finding.1 He had examined the blood groups of freemartin cattle, which are fraternal twins born from a common placenta, and concluded that their blood groups ...
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Task-specific tolerance to d-amphetamine

Neuropharmacology, 1984
Rats were trained concurrently on sweetened-milk drinking and bar-press-responding behavior, which alternated on a daily basis. Dose-response functions for d-amphetamine were determined before and after conditions of chronic treatment. When given before chronic treatment, d-amphetamine decreased both milk consumption and reinforcement received for ...
M W, Emmett-Oglesby, D G, Spencer, D M, Wood, H, Lal   +3 more
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