Results 261 to 270 of about 202,194 (309)
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Determination of Organ-Specific Anemia Tolerance*
Critical Care Medicine, 2013Utilization of anemia tolerance reduces the need for and risks of perioperative transfusion. Recent publications indicate that the critical limit for oxygen supply might not be the same for each organ system. Therefore, we investigated the effects of acute dilutional anemia on heart, brain, kidneys, liver, small intestine, and skeletal muscle to ...
Patrick, Lauscher +6 more
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Tolerance and Specificity of Polyketide Synthases
Annual Review of Biochemistry, 1999▪ Abstract Polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis. Like fatty acids, polyketides are assembled by successive decarboxylative condensations of simple precursors.
C, Khosla +3 more
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Specific Tolerance Induction and Organ Transplantation
Leukemia & Lymphoma, 1998Induction of tolerance to histocompatibility antigens of an organ donor would eliminate the need for long-term administration of nonspecific immunosuppressive drugs associated with an increased risk of infection and malignancies. Recently, we established a murine model in which recipient mice were treated with a single dose of anti-CD3, anti-CD4, low ...
A, de Vries-van der Zwan +4 more
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Peripheral Tolerance and Organ Specific Autoimmunity
2001Concepts of specific immunotolerance were first introduced after the clonal selection theory gained acceptance. In early days Burnet and Lederberg formulated the simple concept that there was a fundamental difference between immature and mature, antigen-receptor bearing lymphocytes such that binding of antigen by the former would result in cell death ...
H, von Boehmer, E, Jaeckel
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Tolerance to d-amphetamine: Behavioral specificity
Life Sciences, 1976Abstract In a Y-maze exploratory task mice tend to enter that compartment which was least recently visited (spontaneous alternation). Low doses of d-amphetamine (1.0 mg/kg) reduce alternation to chance levels, while high doses (10.0 mg/kg) result in animals successively visiting only two compartments of the Y-maze (perseveration).
L, Kokkinidis +3 more
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Antigen‐specific transplantation tolerance
Clinical Transplantation, 1990Two animal models are described which are currently being studied in this laboratory in attempts to induce specific transplantation tolerance across major histocompatibility barriers. One model involves the use of minature swine selectively inbred at the MHC.
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Tolerance Specification for Cost Reduction
Volume 3: 7th Design for Manufacturing Conference, 2002The paper presents a novel optimal tolerance specification technique to minimize product cost. By introducing the properties of order statistics and the theory of tolerance limit to the traditional simulation method, a n dimensional tolerance search problem is transformed into a two dimensional one.
Jianmin Zhu, Kwun-Lon Ting
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Biofilm-specific antibiotic tolerance and resistance
European Journal of Clinical Microbiology & Infectious Diseases, 2015Biofilms are heterogeneous structures composed of bacterial cells surrounded by a matrix and attached to solid surfaces. The bacteria here are 100 to 1,000 times more tolerant to antimicrobials than corresponding planktonic cells. Biofilms can be difficult to eradicate when they cause biofilm-related diseases, e.g., implant infections, cystic fibrosis,
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A SPECIFIC IMMUNOLOGICAL TOLERANCE IN RADIATION CHIMERAS
Plastic and Reconstructive Surgery, 1962Repopulation of the bone marrow and lymph nodes with donor-type cells was demonstrated in C57BL/Rij and (CBA/Rij x C57BL/Rij)F/sub 1/ mice that had been exposed to a lethal dose of total body x irradiation and treated with CBA bone marrow cells. No apparent symptom s of secondary disease were found in those chimeras that survived 100 days after ...
Vos, O, Weyzen, W W
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Glycosylphosphatidylinositol-specific phospholipase D improves glucose tolerance
Metabolism, 2010Insulin regulation of energy metabolism is complex and involves numerous signaling cascades. Insulin has been suggested to stimulate a phospholipase that cleaves glycosylphosphatidylinositols resulting in the generation of an inositol glycan that serves as an insulin mediator.
Nandita S, Raikwar +4 more
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