Results 81 to 90 of about 9,025 (290)

Tolerance before Secularism: Models of Tolerance in Nineteenth-Century Arabic

Religions
By analyzing temporal language, this study investigates the intellectual origins and the conceptual history of three concepts of tolerance that emerged in the Arabic context towards the end of the 19th century.
Wael Abu-ʿUksa
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

İSPANYA'DA İSLAM VE HRİSTİYAN MANEVİYATI: Özet TEMASLAR, TESİRLER, BENZERLiKLER

Cumhuriyet Üniversitesi İlahiyat Fakültesi Dergisi, 2012
İspanya'da üç tek tanrılı dinin -özellikle Hıristiyanlık ve İslam'ındokuz yüzyıl bir arada bulunuşu çok sayıda temaslar, karşılıklı etkilenmeler ve inkar edilemez benzerlikler ortaya çıkarmıştır. Yazar, Kastilyalı III.
Francisco de Borja de Medina, Rıza BAKIŞ   +1 more
doaj  

Mémoires de la Saint-Barthélemy

Etudes Epistémè
At the start of the twenty-first century, 450 years after the massacre of St Bartholomew’s Day, the remembrance of this tragic ‘bloody night’ has re-emerged with force in the collective memory and in the public sphere. This revival is not just the result
Tatiana Debbagi Baranova, Julien Goeury, Anne-Marie Miller-Blaise   +2 more
doaj   +1 more source

Becoming Begrudgingly Tolerant

Central Europe, 2021
The concept of religious tolerance and toleration has been the subject of much scholarly discussion for centuries. In the wake of the Reformation, however, it became a much more practical concept, with Europeans living next door to people perceived as ...
Andrew Wood-Martin
doaj  

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Review of Everyone Orthodox to Themselves: John Locke and His American Students on Religion and Liberal Society by John Colman

Locke Studies
A review of John Colman’s recent book Everyone Orthodox to Themselves: John Locke and His American Students on Religion and Liberal Society (Lawrence: University of Kansas Press, 2023)
Benjamin Haines
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source