Results 211 to 220 of about 24,183 (235)

Potential of tolerogenic dendritic cells for transplantation

Seminars in Immunology, 2001
Dendritic cells (DC) are professional antigen (Ag)-presenting cells considered traditionally as the passenger leukocytes that, after migration from transplanted tissues, stimulate allospecific naive T cell responses and trigger acute rejection. However, there is recent evidence that, besides their role in central T lymphocyte deletion in the thymus, DC
A E, Morelli, H, Hackstein, A W, Thomson
openaire   +2 more sources

Tolerogenic dendritic cells

Current Opinion in Organ Transplantation, 2012
We discuss the use of tolerogenic dendritic cells (TolDCs) as a therapeutic tool in solid organ transplantation, with particular emphasis on recent experimental and preclinical data supporting the clinical translation of TolDC therapy.TolDC have been successfully used in rodents to promote long-term allograft survival.
Gaelle, Beriou, Aurelie, Moreau, Maria C, Cuturi   +2 more
openaire   +2 more sources

Tolerogenic dendritic cells for autoimmune disease and transplantation

Annals of the Rheumatic Diseases, 2008
Dendritic leucocytes are professional antigen-presenting cells with inherent tolerogenic properties and are regarded as critical regulators of innate and adaptive immunity. Modification of dendritic cells (DCs) in the laboratory can enhance and stabilise their tolerogenic properties. Numerous reports suggest that such immature, maturation-resistant or "
A W, Thomson, P D, Robbins
openaire   +2 more sources

Use of Rapamycin in the Induction of Tolerogenic Dendritic Cells

2008
Rapamycin (RAPA), a macrocyclic triene antibiotic pro-drug, is a clinically-utilized 'tolerance-sparing' immunosuppressant that inhibits the activity of T, B, and NK cells. Furthermore, maturation-resistance and tolerogenic properties of dendritic cells (DC) can be supported and preserved by conditioning with RAPA. Propagation of murine bone marrow (BM)
Ryan, Fischer, Heth R, Turnquist, Timuçin, Taner, Angus W, Thomson   +3 more
openaire   +2 more sources

Tolerogenic Dendritic Cells: The Ins and Outs of Outcome

Journal of Immunotherapy, 2006
Recent studies point to an important role for dendritic cells (DCs) in the induction of peripheral tolerance, revealing that the maturation and/or activation state of DCs might be a control point for the induction of peripheral tolerance. Recent progress in our understanding of the mechanisms mediating immune tolerance indicates them to be far more ...
Bao-Guo, Xiao, Yu-Min, Huang, Hans, Link
openaire   +2 more sources

Potential of Tolerogenic Dendritic Cells in Transplantation

Current Transplantation Reports, 2016
Dendritic cells (DC) are the most important subset of antigen presenting cells (APC) that are able to polarize the immune response to pro-inflammatory or anti-inflammatory response. This duality places DC in the axis between tolerance and immunogenicity.
Marín, Eros, Cuturi, Maria Cristina, Moreau, Aurélie   +2 more
openaire   +2 more sources

Tolerogenic Dendritic Cells for Type 1 Diabetes

Immunotherapy, 2013
Evaluation of: Pujol-Autonell I, Ampudia RM, Monge P et al. Immunotherapy with tolerogenic dendritic cells alone or in combination with rapamycin does not reverse diabetes in NOD mice. ISRN Endocrinol. doi:10.1155/2013/346987 (2013) (Epub ahead of print).
openaire   +2 more sources

Tolerogenic dendritic cells and their potential applications.

Immunology, 2011
Dendritic cells (DCs) play a pivotal role in regulating the balance between immunity and tolerance of the immune system. Recent advancements in DC biology and techniques for manipulating the function of these cells have shown their immense therapeutic potential for treating a variety of immune disorders.
Jim, Hu, Yonghong, Wan
openaire   +1 more source

Immunomodulation by subcutaneously injected methacrylic acid-based hydrogels and tolerogenic dendritic cells in a mouse model of autoimmune diabetes

Biomaterials, 2023
Sean M Kinney, Michael V Sefton
exaly  

Therapeutic effects of tolerogenic dendritic cells

Nature Reviews Rheumatology, 2010
openaire   +2 more sources