Results 201 to 210 of about 219,955 (241)

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
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Molecular cloning and functional analysis of duck Toll-like receptor 5

Research in Veterinary Science, 2014
Toll-like receptor 5 (TLR5) is responsible for the recognition of bacterial flagellin in vertebrates. In this study, we cloned the single-exon TLR5 gene of the Maya breed of Common Shelduck (Tadorna tadorna). The TLR5 open reading frame is 2580 bp in length and encodes an 859-amino acid protein.
Dan, Xiong, Zhiming, Pan, Xilong, Kang, Jing, Wang, Li, Song, Xinan, Jiao   +5 more
openaire   +2 more sources

Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin

Journal of Structural Biology, 2012
The structure of full-length human TLR5 determined by electron microscopy single-particle image reconstruction at 26Å resolution shows that TLR5 forms an asymmetric homodimer via ectodomain interactions. The structure shows that like TLR9, TLR5 dimerizes in the absence of ligand. The asymmetry of the dimer suggests that TLR5 may recognize two flagellin
Kaifeng, Zhou, Ryuta, Kanai, Phong, Lee, Hong-Wei, Wang, Yorgo, Modis   +4 more
openaire   +2 more sources

Molecular cloning and functional studies on magang goose toll-like receptor 5

Veterinary Immunology and Immunopathology, 2021
Disease outbreaks heavily impact the economic viability of animal industries. Little is known about the mechanisms of immune system-related diseases in geese. Toll-like receptors (TLRs) play a major role in the anti-inflammatory immunity process in most animal species, but they have not been studied in the Magang goose.
Lian-Yun Wu, Shao-Feng Liu, Guo-Hong Hua, Ru-Min Jia, Yan-Hong Yong, Ravi Gooneratne, Xiang-Hong Ju   +6 more
openaire   +2 more sources

Toll like receptor-5: protecting the gut from enteric microbes

Seminars in Immunopathology, 2007
The intestine is normally colonized by a large and diverse commensal microbiota and is occasionally exposed to a variety of potential pathogens. In recent years, there has been substantial progress made in identifying molecular mechanisms that normally serve to protect the intestine from such enteric bacteria and which may go awry in chronic idiopathic
Matam, Vijay-Kumar, Jesse D, Aitken, Andrew T, Gewirtz   +2 more
openaire   +2 more sources

Toll-Like Receptor-5 and the Innate Immune Response to Bacterial Flagellin

2002
The innate immune system identifies the presence of infection by detecting structures that are unique to microbes and that are not expressed in the host. The bacterial flagellum (Latin, a whip) confers motility, on a wide range of bacterial species. Vertebrates, plants, and invertebrates all have evolved flagellar recognition systems that are activated
K D, Smith, A, Ozinsky
openaire   +2 more sources

Molecular cloning, characterization and expression of goose Toll-like receptor 5

Molecular Immunology, 2012
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) that are vital to activation of the innate immune system in response to invading pathogens through their recognition of pathogen-associated molecular patterns (PAMPs). TLR5 is responsible for the recognition of bacterial flagellin in vertebrates. In this study, we cloned the goose TLR5
Qiang, Fang, Zhiming, Pan, Shizhong, Geng, Xilong, Kang, Jinlin, Huang, Xiaolin, Sun, Qiuchun, Li, Yinqiang, Cai, Xinan, Jiao   +8 more
openaire   +2 more sources

Human conjunctival epithelial cells express functional Toll-like receptor 5

British Journal of Ophthalmology, 2008
The expression and function of Toll-like receptor 5 (TLR5) was analysed in human conjunctival epithelial cells (HCjEC).The expression of TLR5 in HCjEC was studied by reverse transcriptase (RT) PCR and flow cytometry. The amount of interleukin (IL) 6 and IL-8 proteins was determined by ELISA.
K, Kojima, M, Ueta, J, Hamuro, Y, Hozono, S, Kawasaki, N, Yokoi, S, Kinoshita   +6 more
openaire   +2 more sources

Increased expression of Toll-like receptor 5 during progression of cervical neoplasia

International Journal of Gynecological Cancer, 2008
The purpose of this study was to determine whether Toll-like receptor 5 (TLR5) expression was associated with disease progression in cervical neoplasia. TLR5 expression was evaluated by immunohistochemistry (IHC) in 55 formalin-fixed paraffin-embedded cervical tissues; 10 normal cervical specimens, 9 low-grade cervical intraepithelial neoplasias (CINs),
W Y, Kim, J-W, Lee, J-J, Choi, C H, Choi, T-J, Kim, B-G, Kim, S Y, Song, D-S, Bae   +7 more
openaire   +2 more sources

Regulation of adipogenesis by toll-like receptor 5 pathway

2016
Toll-like receptor 5 (TLR5) recognizes the bacterial product, flagellin. Its activation leads to cytokine production that is important for host defense against invading pathogens. In spite of the pro-inflammatory nature of TLR5, deficiency of TLR5 exacerbated metabolic dysfunction in diet-induced obese mouse model (Gewirtz et al. Science, 328: 228-231,
YIU, JHC, LI, J, Xu, A, Woo, WHC
openaire   +2 more sources