Results 91 to 100 of about 396,801 (209)

Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease [PDF]

open access: yes, 2014
Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease (ALD). Currently, ALD is considered to be one of the major causes of death worldwide.
Alisi, A., Ceccarelli, S, Nobili, V
core   +1 more source

Cell-free synthesis of human toll-like receptor 9 (TLR9): Optimization of synthesis conditions and functional analysis.

open access: yesPLoS ONE, 2019
The Toll-like receptor family belongs to the group of pathogen recognition receptors which is responsible for the discrimination of self and non-self pathogen-associated molecular patterns (PAMP's).
Srujan Kumar Dondapati   +4 more
doaj   +1 more source

Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6 [PDF]

open access: yes, 2011
The Toll/interleukin-1 receptor (TIR) domain is a protein-protein interaction domain that is found in both animal and plant immune receptors. In animal Toll-like receptor signalling, both homotypic TIR-domain interactions between two receptor molecules ...
Dodds, Peter N.   +5 more
core   +1 more source

Host genetic factors modulating dengue virus: a systematic review of TLR polymorphisms

open access: yesBMC Infectious Diseases
Background Dengue virus (DENV) infection is a substantial global public health burden, affecting ~ 390 million people every year, with a mortality rate of ~ 2.5% of those requiring hospitalization.
Damiana Sapta Candrasari   +4 more
doaj   +1 more source

let-7 microRNAs regulate microglial function and suppress glioma growth through Toll-like receptor 7 [PDF]

open access: yes, 2019
Microglia express Toll-like receptors (TLRs) that sense pathogen- and host-derived factors, including single-stranded RNA. In the brain, let-7 microRNA (miRNA) family members are abundantly expressed, and some have recently been shown to serve as TLR7 ...
Buonfiglioli, Alice   +2 more
core   +1 more source

Serum soluble toll-like receptor 4 and risk for clinical severity in COVID-19 patients

open access: yesPneumonia
Toll-like receptor 4 (TLR4) signaling mediates sustained systemic inflammation in(COVID)-19 patients. We aimed to assess the serum levels of sTLR4 and sCD14 as negative regulators of Toll like receptor signaling and their association with laboratory ...
Maha E. Houssen   +7 more
doaj   +1 more source

Species-Specific Recognition of Aspergillus fumigatus by Toll-like Receptor 1 and Toll-like Receptor 6 [PDF]

open access: yes, 2017
Background. Aspergillus fumigatus causes invasive aspergillosis, a potentially fatal infection in oncohematological patients. Innate immune detection of A. fumigatus involves Toll-like receptor (TLR) 4 and TLR2, which forms a heterodimer with either TLR1
Bochud, Pierre-Yves   +9 more
core  

Toll-Like Receptor 3 in Liver Diseases

open access: yesGastroenterology Research and Practice, 2010
Toll-like receptor 3 (TLR3) is a member of the TLR family that can recognize double-stranded RNA (dsRNA), playing an important role in antiviral immunity.
Shi Yin, Bin Gao
doaj   +1 more source

Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis

open access: yesCell Reports, 2014
Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice.
Isabelle K. Vila   +18 more
doaj   +1 more source

Bacterial Lipopolysaccharide Activates Toll-Like Receptor 2 and Toll-Like Receptor 4 Gene Expression in PBMC of Vechur Cattle

open access: yesInternational Journal of Bio-Resource and Stress Management, 2021
Vechur cattle, an indigenous breed of Kerala and it is the smallest cattle breed in the world. They are highly disease resistant. The occurrence of mastitis is very Rare in this breed as compared to crossbred cattle.
R. Lakshmi   +3 more
doaj  

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