Results 141 to 150 of about 363,419 (348)
NF-{kappa}B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [PDF]
, 2006 Activation of mammalian innate and acquired immune responses must be tightly regulated by elaborate mechanisms to control their onset and termination. MicroRNAs have been implicated as negative regulators controlling diverse biological processes at the ...
Baltimore, David +3 more
core
Advanced Science, EarlyView.Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang +12 more
wiley +1 more source
Journal of the Egyptian Womenʼs Dermatologic Society, 2018 Eman Nofal +3 more
openaire +1 more source
A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4
Advanced Science, EarlyView.This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He +11 more
wiley +1 more source
The Soluble Form of Toll-Like Receptor 2 Is Elevated in Serum of Multiple Sclerosis Patients: A Novel Potential Disease Biomarker [PDF]
, 2018 Md Jakir Hossain +8 more
openalex +1 more source
Advanced Science, EarlyView.Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei +10 more
wiley +1 more source
Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer [PDF]
, 2022 Fraser R. Millar +22 more
openalex +1 more source
Advanced Science, EarlyView.Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye +12 more
wiley +1 more source
Expression of Toll-Like Receptor 2 on Human Schwann Cells: a Mechanism of Nerve Damage in Leprosy
, 2003 Rosane B. de Oliveira +6 more
openalex +1 more source
The R753Q Polymorphism Abrogates Toll‐Like Receptor 2 Signaling in Response to Human Cytomegalovirus [PDF]
, 2009 Robert A. Brown +2 more
openalex +1 more source