Results 151 to 160 of about 225,548 (263)

MiR‐146a‐5p Suppresses M1 Polarization of Tumor‐Associated Macrophages via IRAK1/NF‐κB Signaling in Colorectal Polyps

Annals of Gastroenterological Surgery, EarlyView.
MiR‐146a‐5p is downregulated in colorectal polyps, leading to IRAK1 upregulation and NF‐κB activation, which promotes M1 macrophage polarization and inflammation. Overexpression of miR‐146a‐5p suppresses IRAK1/NF‐κB signaling, reduces M1 polarization, and alleviates inflammatory responses.
Peng Song, Lianhui Wu, Huabin Qiu, Lei Luo, Jianzhao Qiu, Shuping Xiao, Jincai He   +6 more
wiley   +1 more source

Dual-Action Theranostic Nanoparticles Delivering Toll-Like Receptor 2 Inhibitors and Chemotherapy Target Breast Cancer Cells and the Tumor Microenvironment. [PDF]

Int J Nanomedicine
Di Lorenzo A, Romiti C, Amaolo A, Cossu C, Iacoviello A, Curcio C, Forni M, Zanini C, Cavallo F, Ferrauto G, Di Gregorio E, Conti L.   +11 more
europepmc   +1 more source

The psychosocial toll of Dublin III on asylum seekers in the Netherlands

American Journal of Community Psychology, EarlyView.
Abstract The Dublin III Regulation determines which EU Member State is responsible for examining asylum claims, but its implementation carries significant consequences for those subjected to it. This study examines how Dublin III, as implemented in the Netherlands, affects asylum seekers' psychosocial wellbeing using Silove′s Adaptation and Development
Imen El Amouri
wiley   +1 more source

<i><b>Muribaculum intestinale</b></i> <b>negatively impacts glioma growth in mice through the toll-like receptor 2</b>. [PDF]

Gut Microbes
Marrocco F, Cocozza G, Antonangeli F, Khan R, Pietropaolo G, Elkihel A, Favaretto G, Lin X, Mancinelli R, Busdraghi LM, Reccagni A, Scarno G, Sciumè G, Laffranchi M, Peng L, Iebba V, Sozzani S, D'Alessandro G, Limatola C.   +18 more
europepmc   +1 more source

Diagnosing the system: Mental health, necropolitical uncare, and the abolition of migration detention

American Journal of Community Psychology, EarlyView.
Abstract This article examines the psychological effects of migration detention in the European Union's Closed Controlled Access Center (CCAC) on Samos through an ecological lens. It explores a double normalization of suffering: the brutalization of necropolitical migration governance and the simultaneous understanding of resulting distress as an ...
Julia Manek
wiley   +1 more source

Induced pluripotent stem cell-derived platelets kill multidrug-resistant <i>Staphylococcus aureus</i> via Toll-like receptor 2-MyD88 signaling and immunoglobulin G/FcγRIIA engagement. [PDF]

Res Pract Thromb Haemost
Lin Q, Nonomura K, Stirblyte I, Nakamura S, Uchiyama S, Yamaguchi M, Kawabata S, Nagao M, Suzuki-Inoue K, Nizet V, Eto K, Sugimoto N.   +11 more
europepmc   +1 more source

The Diagnosis That Arrived Decades Late: Living Without and Then With Myhre Syndrome

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MIM #139210) is a rare multisystem disorder first described in 1981, characterized by short stature, neurodevelopmental delay, joint contractures, and cardiopulmonary complications. Its molecular basis, recurrent pathogenic variants in SMAD4, was not discovered until 2011. This narrative is based on a review of medical records,
Abdallah F. Elias
wiley   +1 more source

Toll like receptor 2 mediated exacerbation of sepsis associated acute kidney injury by renal congestion in mice. [PDF]

Sci Rep
Nakamura I, Umehara M, Yagi-Tomita A, Yamamoto S, Sawai S, Nakamura M, Minamida A, Yamauchi-Sawada H, Sunahara Y, Matoba Y, Okuno-Ozeki N, Nakai K, Nakata T, Kitani T, Yamashita N, Komaki K, Kirita Y, Tamagaki K, Matoba S, Kusaba T.   +19 more
europepmc   +1 more source

Navigating Whiteness in Australia's Anti‐Racism Movement: A Duoethnographic Inquiry by Women of Colour Scholars

Australian Journal of Social Issues, EarlyView.
ABSTRACT This paper applies Critical Race Theory (CRT) to explore how whiteness operates within Australia's anti‐racism movement as a structuring force that shapes discourse, practice and policy. Despite the anti‐racism movement offering crucial spaces for resistance and reform, it remains entangled in Australia's settler‐colonial present and systemic ...
Franka Vaughan, Aish Ravi
wiley   +1 more source

Toll-like receptor 2 deficiency exacerbates corneal angiogenesis in injury by impairing regulatory T cells. [PDF]

Theranostics
Ko JH, Lee HJ, Kim HJ, Ryu JS, Choi YR, Yoon CH, Song HB, Kim D, Lee RH, Oh JY.   +9 more
europepmc   +1 more source