Results 201 to 210 of about 537,344 (241)

The Toll of Toll-Like Receptors, Especially Toll-Like Receptor 2, on Murine Atherosclerosis

Current Drug Targets, 2007
At one time, atherosclerosis was thought to be a simple lipid storage disease. However, it is now recognized as a chronic and progressive inflammation of the arterial wall. Gene deletion experiments in murine models of atherosclerosis that reduce the inflammatory process also reduce disease severity.
L K, Curtiss, P S, Tobias
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Expression of Toll-like Receptor 2 and Toll-like Receptor 4 in Tuberculous Pleural Effusion

Medicinal Chemistry, 2017
Toll-like receptor-2 (TLR2) and Toll-like receptor-4 (TLR4) have been reported to play a crucial role in tuberculosis, however, little is known about their expression in tuberculous pleuritis.The goal of this work is to explore the expressions of TLR2 and TLR4 in tuberculous pleuritis and their predominant expressions on cells.Levels of soluble TLR2 ...
Yingzhong, Lin, Tingmei, Feng, Jiao, Lan, Chunxia, Chen, Zhiqiang, Qin, Yanbin, Wu, Huanzhong, Shi, Jianbo, Ye, Caizhou, Wei, Wu, Wang, Luying, Huang   +10 more
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Toll‐like Receptor‐2 and Toll‐like Receptor‐4 Expression on Maternal Neutrophils During Pregnancy

American Journal of Reproductive Immunology, 2010
Nitsche JF, Jiang S‐W, Brost BC. Toll‐like receptor‐2 and toll‐like receptor‐4 expression on maternal neutrophils during pregnancy. Am J Reprod Immunol 2010; 64: 427–434Problem  Toll‐like receptors (TLR) are an important part of the innate immune system and are present in a variety of human tissues.
Joshua F, Nitsche, Shi-Wen, Jiang, Brian C, Brost   +2 more
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Comparative fine maps of bovine toll-like receptor 4 and toll-like receptor 2 regions

Mammalian Genome, 2003
Toll-like receptors are cell-surface receptors that activate innate and adaptive immune responses. We have used a 5000-rad, whole-genome radiation hybrid panel to map Toll-like receptor 4 (TLR4) to the distal end of bovine Chromosome (Chr) 8, and Toll-like receptor 2 (TLR2) to the proximal end of bovine Chr 17.
Stephen N, White, Srinivas R, Kata, James E, Womack   +2 more
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Toll-Like Receptor 2 and Renal Allograft Function

American Journal of Nephrology, 2008
<i>Background:</i> Toll-like receptors (TLR) modulate the immune response. We analyzed the relationships between TLR expression in renal tissue with infection, rejection and graft function after kidney transplantation. <i>Methods:</i> TLR-2 and TLR-4 expression was detected by immunohistochemistry in 257 protocol biopsies ...
Kirsten, de Groot, Katharina, Kuklik, Verena, Bröcker, Anke, Schwarz, Wilfried, Gwinner, Hans, Kreipe, Hermann, Haller, Danilo, Fliser, Michael, Mengel   +8 more
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Salivary and Plasma Levels of Toll‐Like Receptor 2 and Toll‐Like Receptor 4 in Chronic Periodontitis

Journal of Periodontology, 2011
Background: This cross‐sectional study was planned to investigate whether patients with chronic periodontitis exhibit different salivary or plasma concentrations of Toll‐like receptor (TLR) 2 and TLR4 compared to subjects who are clinically healthy.Methods: Whole saliva and plasma samples were obtained and full‐mouth clinical periodontal measurements ...
Buduneli, Nurcan, Ozcaka, Ozgun, Nalbantsoy, Ayse   +2 more
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Decreased Toll-Like Receptor 2 and Toll-Like Receptor 7/8-Induced Cytokines in Parkinson's Disease Patients

Neuroimmunomodulation, 2016
<b><i>Objectives:</i></b> Toll-like receptors (TLRs) are expressed in several immune cells including blood monocytes and resident macrophages, such as microglia in the central nervous system. TLRs recognize pathogen- or damage-associated molecular patterns, leading to the release of inflammatory and toxic molecules, which can ...
Delson José, da Silva, Arissa Felipe, Borges, Priscila Oliveira, Souza, Patrícia Reis, de Souza, Cristina Ribeiro de Barros, Cardoso, Miriam Leandro, Dorta, Milton Adriano Pelli, de Oliveira, Antônio Lúcio, Teixeira, Fátima, Ribeiro-Dias   +8 more
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Nicotine Treatment Improves Toll-Like Receptor 2 and Toll-Like Receptor 9 Responsiveness in Active Pulmonary Sarcoidosis

Chest, 2013
New evidence links nicotine to the regulation of T cell-mediated inflammation via a 7 nicotinic cholinergic receptor activation, and chronic nicotine exposure (smoking) reduces the incidence of granulomatous diseases. We sought to determine whether nicotine treatment was well tolerated while effectively normalizing immune responses in patients with ...
Mark W, Julian, Guohong, Shao, Larry S, Schlesinger, Qin, Huang, David G, Cosmar, Nitin Y, Bhatt, Daniel A, Culver, Robert P, Baughman, Karen L, Wood, Elliott D, Crouser   +9 more
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Reduced soluble Toll-like receptors 2 in type 2 diabetes

Archives of Physiology and Biochemistry, 2017
Soluble forms of Toll-like receptors (sTLR) 2 and 4 exert negative regulatory control on membrane-bound receptor activation. The study estimates the sTLR2 and sTLR4's serum levels in type 2 diabetes (T2D) and evaluates their relationship with metabolic and inflammatory parameters.Sixty three patients with T2D and 25 controls were enrolled.
Emanuela, Zaharieva, Tsvetelina, Velikova, Adelina, Tsakova, Zdravko, Kamenov   +3 more
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Toll-like receptor 2-mediated human B cell differentiation

Clinical Immunology, 2006
Human B cells likely have a major role in the adjuvant activity of Toll-like receptor (TLR) 9 agonists by enhancing innate and adaptive immune responses. As several TLR2 ligands are promising vaccine adjuvant candidates, our aim was to characterize the effects of TLR2 stimulation on human B cell activation and differentiation using cells derived from ...
Lisa M, Ganley-Leal, Xiuping, Liu, Lee M, Wetzler   +2 more
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