Results 201 to 210 of about 460,890 (351)

Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine Macrophages

Infection and Immunity, 2001
M. Hirschfeld, J. Weis, V. Toshchakov, C. Salkowski, M. J. Cody, D. Ward, N. Qureshi, S. Michalek, S. Vogel   +8 more
semanticscholar   +1 more source

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

The function of Toll-like receptor 2 in control of transcriptome responses to the microbiome and microbiome composition. [PDF]

Anim Microbiome
Liu L, Spaink HP.
europepmc   +1 more source

Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis.

Proceedings of the National Academy of Sciences of the United States of America, 2004
E. Kurt-Jones, M. Chan, Shenghua Zhou, Jennifer P. Wang, G. Reed, R. Bronson, M. Arnold, D. Knipe, R. Finberg   +8 more
semanticscholar   +1 more source

Mechanisms by which interleukin-4 suppresses inflammatory cytokine production by activated human monocytes

, 2011
Improving understanding of how inflammatory responses by monocytes and macrophages are regulated may aid in the development of more targeted therapies for chronic inflammatory disease.
Woodward, Eleanor
core  

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Toll-like receptor 2 drives liver senescence and fibrosis in aging through gut-derived microbial signaling. [PDF]

Cell Mol Biol Lett
Brandt A, Staltner R, Baumann A, Burger K, Jelleschitz J, Prada PO, Höhn A, Kopp F, Mayneris-Perxachs J, Fernández-Real JM, Bergheim I.   +10 more
europepmc   +1 more source

Repression of Toll-like receptor-4 by microRNA-149-3p is associated with smoking-related COPD

, 2017
Wen Shen,1,* Jia Liu,2,* Guohou Zhao,1 Minjuan Fan,1 Gao Song,3 Yang Zhang,1 Zhiying Weng,3 You Zhang4 1Department of Respiratory Medicine, 2Department of Experimental Zoology, The Second Affiliated Hospital of Kunming Medical University, 3School of ...
Liu J, Zhang Y, Zhao G, Fan M, Weng Z, Song G, Shen W   +6 more
core  

Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts

Animal Models and Experimental Medicine, EarlyView.
Chronic alcohol exposure disrupts intestinal barrier integrity, resulting in a leaky gut and enhanced translocation of lipopolysaccharide (LPS) and microbial products into the systemic circulation. Alcohol‐induced endotoxemia drives exaggerated pro‐inflammatory responses, mitochondrial damage, and activation of the cGAS–STING pathway, particularly in ...
Thansita Bhunyakarnjanarat, Chatsuree Suksamai, Dhammika Leshan Wannigama, Kent Doi, Wiwat Chancharoenthana, Asada Leelahavanichkul   +5 more
wiley   +1 more source

The role of soluble toll-like receptor-2 and 4 in children with pneumonia: a combined analysis of saliva and serum samples. [PDF]

Front Immunol
Necipoglu O, Demir OO, Aykac K, Karahan S, Cengiz AB, Aydin M, Ozsurekci Y.   +6 more
europepmc   +1 more source