Results 311 to 320 of about 460,890 (351)

Evaluation of Lipopeptides as Toll-like Receptor 2 Ligands

Current Drug Delivery, 2017
Peptide-based vaccines are considered to be the next generation of modern immunizations, as they are safe, easy to produce and well-defined. However, due to their weak immunogenic effect, it is important to first develop an appropriate adjuvant for peptide-based vaccines.The aim of this work was to synthesize a series of four adjuvanting moieties as ...
Hussein, Waleed, Choi, Phil, Zhang, Cheng, Su, Mei, Sierecki, Emma, Johnston, Wayne, Fagan, Vincent, Alexandrov, Kirill, Skwarczynski, Mariusz, Gambin, Yann, Toth, Istvan, Simerska, P.   +11 more
openaire   +4 more sources

Toll‐like Receptor‐2 and Toll‐like Receptor‐4 Expression on Maternal Neutrophils During Pregnancy

American Journal of Reproductive Immunology, 2010
Nitsche JF, Jiang S‐W, Brost BC. Toll‐like receptor‐2 and toll‐like receptor‐4 expression on maternal neutrophils during pregnancy. Am J Reprod Immunol 2010; 64: 427–434Problem  Toll‐like receptors (TLR) are an important part of the innate immune system and are present in a variety of human tissues.
Joshua F, Nitsche, Shi-Wen, Jiang, Brian C, Brost   +2 more
openaire   +2 more sources

Comparative fine maps of bovine toll-like receptor 4 and toll-like receptor 2 regions

Mammalian Genome, 2003
Toll-like receptors are cell-surface receptors that activate innate and adaptive immune responses. We have used a 5000-rad, whole-genome radiation hybrid panel to map Toll-like receptor 4 (TLR4) to the distal end of bovine Chromosome (Chr) 8, and Toll-like receptor 2 (TLR2) to the proximal end of bovine Chr 17.
Stephen N, White, Srinivas R, Kata, James E, Womack   +2 more
openaire   +2 more sources

Role of genetic variants of Vitamin D receptor, Toll-like receptor 2 and Toll-like receptor 4 in extrapulmonary tuberculosis

Microbial Pathogenesis, 2021
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB). Vitamin D deficiency and vitamin D receptor (VDR) gene abnormalities confer susceptibility to tuberculosis. Toll-like receptors (TLRs), such as TLR-2, are also important mediators of inflammatory response against Mycobacterium tuberculosis.
Bilal Ahmad Wani, Faheem Shehjar, Sonaullah Shah, Ajaz Koul, Adfar Yusuf, Muzamil Farooq, Mohmad Iqbal Mir, Rajni Singh, Dil Afroze   +8 more
openaire   +2 more sources

Toll-Like Receptor 2 and Renal Allograft Function

American Journal of Nephrology, 2008
<i>Background:</i> Toll-like receptors (TLR) modulate the immune response. We analyzed the relationships between TLR expression in renal tissue with infection, rejection and graft function after kidney transplantation. <i>Methods:</i> TLR-2 and TLR-4 expression was detected by immunohistochemistry in 257 protocol biopsies ...
Kirsten, de Groot, Katharina, Kuklik, Verena, Bröcker, Anke, Schwarz, Wilfried, Gwinner, Hans, Kreipe, Hermann, Haller, Danilo, Fliser, Michael, Mengel   +8 more
openaire   +2 more sources

Simple synthetic toll-like receptor 2 ligands

Bioorganic & Medicinal Chemistry Letters, 2011
Stimulation of toll-like receptor 2 (TLR2) by bacterial lipoproteins induces fast non-specific immune responses against pathogens followed by slow but specific adaptive immune responses. Development of synthetic TLR2 agonists/antagonists would be useful in the prevention of different infectious and immunologic disorders.
Abdel-Aal, Abu-Baker M., Al-Isae, Kalifa, Zaman, Mehfuz, Toth, Istvan   +3 more
openaire   +5 more sources

Function and Phenotype of Microglia Are Determined by Toll-Like Receptor 2/Toll-Like Receptor 4 Activation Sequence

DNA and Cell Biology, 2009
Toll-like receptors (TLRs) initiate and maintain host defenses. These receptors play important roles in innate immunity and in various diseases. Different TLRs bind to diverse ligands that trigger distinct protein expression patterns. Few studies have focused on the interaction between different TLRs.
Weixin, Li, Guodong, Gao, Qingdong, Guo, Dong, Jia, Julei, Wang, Xuelian, Wang, Shiming, He, Qinchuan, Liang   +7 more
openaire   +2 more sources

Core fucose is essential glycosylation for CD14-dependent Toll-like receptor 4 and Toll-like receptor 2 signalling in macrophages

Journal of Biochemistry (Tokyo), 2018
Core fucosylation, catalysed by α-1, 6 fucosyltransferase (FUT8), regulates growth factor receptors in immune function. Although core fucose regulates many immune cell types, few reports confront the association between core fucose activity and an innate
Kotarosumitomo Nakayama, K. Wakamatsu, Hironobu Fujii, S. Shinzaki, S. Takamatsu, S. Kitazume, Y. Kamada, T. Takehara, N. Taniguchi, E. Miyoshi   +9 more
semanticscholar   +1 more source

[Expression and significance of Toll like receptor 2 and Toll like receptor 4 in chronic rhinosinusitis].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery, 2015
To explore the role of the innate immune factors TLR2 and TLR4 in the pathogenesis of chronic rhinosinusitis (CRS) by detecting their expression in different clinical types of CRS and the normal control group.Immunohistochemistry was used to detect the expression of TLR2 and TLR4 respectively in 21 cases (chronic rhinosinusitis with nasal polyps ...
Xin, Wang, Wenjun, Ji, Yuan, Xu, Huamin, Guo, Chunyuan, Zhao   +4 more
openaire   +1 more source

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.

Science, 1999
A. Aliprantis, Ruey-Bing Yang, M. Mark, Shelly Suggett, B. Devaux, J. Radolf, G. Klimpel, P. Godowski, A. Zychlinsky   +8 more
semanticscholar   +1 more source