Results 121 to 130 of about 352,273 (289)

Activation of Dendritic Cells by the Novel Toll-Like Receptor 3 Agonist RGC100

Clinical and Developmental Immunology, 2013
Toll-like receptor (TLR) 3 agonists emerged as attractive candidates for vaccination strategies against tumors and pathogens. An important mechanism of action of such agonists is based on the activation of TLR3-expressing dendritic cells (DCs), which ...
Kai Naumann, Rebekka Wehner, Anett Schwarze, Christiane Petzold, Marc Schmitz, Jacques Rohayem   +5 more
doaj   +1 more source

SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells [PDF]

, 2011
Background: Severe Acute Respiratory Syndrome (SARS) is characterized by acute respiratory distress (ARDS) and pulmonary fibrosis, and the monocyte/macrophage is the key player in the pathogenesis of SARS. Methods: In this study, we ...
Betty A. Wu-Hsieh, Chuan-Liang Kao, Sher Singh, Wan-Jiung(Wan-Chung) Hu, Yu-Ting Yen   +4 more
core   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Genetic Polymorphism of Toll-like Receptor 4 — Predictor of Susceptibility to Recurrent Course of Chronic Pyelonephritis in Children

Zdorovʹe Rebenka, 2013
Objective of investigation: to study the role of Toll-like receptor 4 Asp299Gly gene polymorphism in the implementation of susceptibility to chronic pyelonephritis, to analyze its association with the major manifestations of the disease and to assess the
T.A. Kryuchko, V.P. Ostapenko, T.V. Kushnereva   +2 more
doaj   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review

Revista da Sociedade Brasileira de Medicina Tropical
Invasive aspergillosis is a common fungal infection in immunocompromised individuals. Some studies have shown that toll-like receptor and dectin-1 genetic polymorphisms may alter signaling pathways, thus increasing an individual’s susceptibility to ...
Daiane de Oliveira Cunha, Jacqueline Andréia Bernardes Leão-Cordeiro, Hellen da Silva Cintra de Paula, Fábio Silvestre Ataides, Vera Aparecida Saddi, Cesar Augusto Sam Tiago Vilanova-Costa, Antonio Márcio Teodoro Cordeiro Silva   +6 more
doaj   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

TLR-9 Expression in Human Bronchial Epithelial Cells induced with Lipopolysaccharide [PDF]

, 2010
The study conducted here was to investigate the gene and protein expression of Toll like receptor 9 when human bronchial epithelial cells were induced by lipopolysaccharide.
Sangeetha Dharmalingam, Shanmuga Saravanabhavan   +1 more
core   +1 more source

Exploring regulation in the Toll‐like receptor 3 pathway

The FASEB Journal, 2011
The innate immune system is the body's first line of defense against infectious agents. Essential to this response are cellular mechanisms that recognize, sequester and eradicate these invading organisms. Toll‐like receptor 3 (TLR3), a pathogen recognition receptor, is stimulated by the viral genomic material double stranded RNA (dsRNA).
James D. Marion, Charlotte F. Roberts, Jessica K. Bell   +2 more
openaire   +1 more source