Results 251 to 260 of about 352,273 (289)

The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection

British Journal of Biomedical Science, 2018
Single nucleotide polymorphisms (SNPs) of Toll-like receptors (TLRs) are linked with functional modification of cytokine responses. In chronic hepatitis C virus (HCV) infection, studies of TLR polymorphisms have primarily targeted receptor pathways implicated in viral immune responses.
M El-Bendary, M Neamatallah, H Elalfy, T Besheer, A Elkholi, M El-Diasty, M Elsareef, M Zahran, B El-Aarag, A Gomaa, D Elhammady, M El-Setouhy, A Hegazy, G Esmat   +13 more
openaire   +2 more sources

Impaired responses to toll-like receptor 4 and toll-like receptor 3 ligands in human cord blood

Journal of Autoimmunity, 2003
Toll-like receptor (TLR)-4 signaling pathway plays an essential role in host defense against gram-negative bacteria while TLR-3-mediated signaling is critically involved in anti-viral immunity. To gain insight into the defects responsible for impaired Th1 responses in human newborns, we investigated the responses of human cord blood cells to ...
De Wit, Dominique, Tonon, Sandrine, Olislagers, Véronique, Goriely, Stanislas, Boutriaux, Michaël, Goldman, Michel, Willems, Fabienne   +6 more
openaire   +3 more sources

Toll-like receptor 3 involvement in vascular function

European Journal of Pharmacology
Maintaining endothelial cell (EC) and vascular smooth muscle cell (VSMC) integrity is an important component of human health and disease because both EC and VSMC regulate various functions, including vascular tone control, cellular adhesion, homeostasis and thrombosis regulation, proliferation, and vascular inflammation.
Takayuki Matsumoto, Takayuki Nagano, Kumiko Taguchi, Tsuneo Kobayashi, Naoko Tanaka-Totoribe   +4 more
openaire   +2 more sources

A key receptor in apoptosis: Toll-like receptor 3 (TLR3).

Journal of Molecular Oncology Research, 2018
The mammals have two types of immune system as innate and acquired immunity. The innate immune system initiates inflammatory response as well as phagocytosis to microbial attack, thus forming the organism's first line of protection. This inflammatory response is the result of induction of pattern recognition receptors (PRRs) which is inherited in the ...
Asuman Deveci Ozkan, Humeyra Nur Kaleli, Suleyman Kaleli   +2 more
openaire   +1 more source

Toll like receptor 3 and viral infections of nervous system

Journal of the Neurological Sciences, 2017
Members of the toll-like receptor (TLR) family are pathogen recognition receptors that recognize pathogen-associated molecular patterns. TLRs mediate the modulation of innate immune responses and influence the development of adaptive immunity. TLR3 is the first identified antiviral TLR that recognizes dsRNA.
Rajesh, Verma, Kavita, Bharti
openaire   +2 more sources

Toll-like receptor 3 is necessary for dsRNA adjuvant effects

Vaccine, 2009
Toll-like receptors (TLR) recognize pathogen associated molecular patterns, and the binding of their specific ligands triggers a proinflammatory response that helps to fight invading microorganisms, and can be harnessed to increase vaccine efficiency.
Salaun B, Greutert M, Romero P
openaire   +3 more sources

The Exploitation of Toll-like Receptor 3 Signaling in Cancer Therapy

Current Pharmaceutical Design, 2014
Toll-like receptors (TLRs) are a group of transmembrane receptors that recognize molecular motifs of pathogen origin and activate immune response. Although TLRs were first identified in immune system cells, recent studies show they can also be expressed in tumor cells.
Tanja Matijevic, Glavan, Jasminka, Pavelic   +1 more
openaire   +2 more sources

Toll-Like Receptor 3: Involvement with Exogenous and Endogenous RNA

International Reviews of Immunology, 2010
The recognition of pathogens is assigned to an evolutionarily conserved family of receptors, the Toll-like receptors (TLRs). The investigation of RNA-based immunology has been reinvigorated with the observation that TLR3s interact with RNA (dsRNA of viral origin, poly (I:C) and endogenous RNA).
Marla Karine, Amarante, Maria Angelica Ehara, Watanabe   +1 more
openaire   +2 more sources

Activation of Toll-Like Receptor 3 Augments Myofibroblast Differentiation

American Journal of Respiratory Cell and Molecular Biology, 2009
Abstract Airway remodeling is observed in the airways of patients with asthma, and differentiation of fibroblasts to myofibroblasts plays a critical role in the progress of airway remodeling. Viral infection induces not only the disease development and exacerbations but also airway remodeling.
Hisatoshi, Sugiura, Tomohiro, Ichikawa, Akira, Koarai, Satoru, Yanagisawa, Yoshiaki, Minakata, Kazuto, Matsunaga, Tsunahiko, Hirano, Keiichiro, Akamatsu, Masakazu, Ichinose   +8 more
openaire   +2 more sources

The toll (like receptor 3) to the pathogenesis of herpes simplex encephalitis

Neurology, 2014
Herpes simplex virus 1 (HSV-1) is a ubiquitous human virus that infects the majority of the world's population. Following primary infection, it becomes latent in neurons in cranial and dorsal root ganglia, from which periodic reactivations typically result in oral and less commonly genital mucosal lesions. In contrast to mucosal disease, herpes simplex
Israel, Steiner, Kenneth L, Tyler
openaire   +2 more sources