Results 181 to 190 of about 347,248 (305)

Urothelial collective-gliding response acts as a toll-like receptor 4-associated defense mechanism. [PDF]

iScience
Zhang N, Sano T, Ito K, Ito S, Ikeuchi R, Takada H, Nakamura K, Sakatani T, Hamada A, Takeda M, Murakami K, Kita Y, Sumiyoshi T, Goto T, Saito R, Ogawa O, Matsuda M, Kobayashi T.   +17 more
europepmc   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

The innate immune response in SARS-CoV2 infection: focus on toll-like receptor 4 in severe disease outcomes. [PDF]

Front Immunol
Maggi E, Landolina N, Mariotti FR, Munari E, Tumino N, Vacca P, Azzarone B, Moretta L.   +7 more
europepmc   +1 more source

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.

Immunity, 2014
M. Venkatesh, Subhajit Mukherjee, Hongwei Wang, Hao Li, Katherine Y. Sun, Alexandre P Benechet, Zhijuan Qiu, Leigh Maher, M. Redinbo, Robert S. Phillips, J. Fleet, Sandhya Kortagere, Paromita Mukherjee, Alessio Fasano, Jessica Le Ven, Jeremy K. Nicholson, M. Dumas, K. Khanna, S. Mani   +18 more
semanticscholar   +1 more source

Selenium Nanomaterials for Wound Healing: Synergistic Strategies from Anti‐Infection to Tissue Regeneration

Advanced NanoBiomed Research, EarlyView.
Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen, Xiaoshuang Liang, Sirui Li, Shuoshan Li, Wei Liu, Yingping Lin, Siqi Li, Zehang Zhang, Judun Zheng, Tianfeng Chen, Rongyi Chen   +10 more
wiley   +1 more source

Necrotizing Enterocolitis: A Comprehensive Review on Toll-like Receptor 4-Mediated Pathophysiology, Clinical, and Therapeutic Insights. [PDF]

Biomedicines
Ishiyama A, Jang HS, Dintaman JM, Duess JW, Tragesser C, Sodhi CP.   +5 more
europepmc   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

Toll-like receptor-4 antagonism mediates benefits during neuroinflammation

Neural Regeneration Research, 2016
Sagar Gaikwad, Challagundla Naveen, Reena Agrawal-Rajput   +2 more
doaj   +1 more source

Activation of chicken macrophages by isomalto/malto-polysaccharide (IMMP) is facilitated by toll-like receptor 4 (TLR4). [PDF]

Poult Sci
Ijaz A, Putman M, Broere F, Rutten VPMG, Jansen CA, Veldhuizen EJA.   +5 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source