Results 211 to 220 of about 347,248 (305)

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Toll-Like Receptor-4 Signaling Pathway Influenced the Exosome Biogenesis and Angiogenesis in Human Triple-Negative Breast Cancer Cells. [PDF]

Adv Pharm Bull
Khanicheragh P, Biray Avci Ç, Abbasi-Malati Z, Sabour Takanlou M, Sabour Takanlou L, Rahbarghazi R, Hasani A.   +6 more
europepmc   +1 more source

A Cooperative Release of Mitochondrial DNA From Platelets and Neutrophils Drives an Interferon Signature in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Retraction: Olanzapine-induced activation of hypothalamic astrocytes and toll-like receptor-4 signaling via endoplasmic reticulum stress were related to olanzapine-induced weight gain. [PDF]

Front Neurosci
Frontiers Editorial Office.
europepmc   +1 more source

Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide‐Induced Toll‐Like Receptor 4 Endocytosis and Macrophage Activation

Immunity, 2018
Michael S. Schappe, K. Szteyn, M. Stremska, Suresh K. Mendu, Taylor K. Downs, Philip V Seegren, Michelle Mahoney, Sumeet Dixit, Julia K. Krupa, Eric J. Stipes, Jason S. Rogers, Samantha E. Adamson, N. Leitinger, Bimal N. Desai   +13 more
semanticscholar   +1 more source

CD14 plays a critical role in pain and inflammation across multiple models of post‐traumatic osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine OA models that vary in severity of pathology and rate of progression, to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Toll-like receptor 4 (TLR-4) polymorphisms and asthma risk in rural and urban settings: findings from the UK biobank. [PDF]

Ups J Med Sci
Kisiel MA, Rask-Andersen M, Johansson Å, Ek WE, Rask-Andersen A.   +4 more
europepmc   +1 more source

Toll-like receptor 4 is a sensor for autophagy associated with innate immunity.

Immunity, 2007
Yi Xu, C. Jagannath, Xian-de Liu, A. Sharafkhaneh, E. Katarzyna, Kolodziejska, N. Eissa   +6 more
semanticscholar   +1 more source

Long Non‐Coding RNA H19 mediates STAT3 dependent activation of keratinocytes and fibroblasts in Systemic Sclerosis skin

Arthritis &Rheumatology, Accepted Article.
Objective Dermal Systemic Sclerosis (SSc) fibroblasts and their exosomes can activate keratinocytes in SSc, with lncRNA H19 (H19) highlighted as the most upregulated RNA in their cargo compared to healthy control (HC). The role of H19 in SSc pathogenesis has never been investigated.
Begoña Caballero‐Ruiz, Christopher W Wasson, Rebecca L Ross, Francesco Del Galdo   +3 more
wiley   +1 more source

In Vitro Effects of Lipopolysaccharide on Rabbit Sperm: Toll-like Receptor 4 Expression, Motility, and Oxidative Status. [PDF]

Antioxidants (Basel)
Quattrone A, Fehri NE, Agradi S, Menchetti L, Barbato O, Castrica M, Sulçe M, Castellini C, Muça G, Mattioli S, Vigo D, Migni G, Nompleggio L, Belabbas R, Gualazzi F, Ricci G, Postoli R, Di Federico F, Moretti E, Zalla P, Collodel G, Brecchia G, Curone G.   +22 more
europepmc   +1 more source