Results 261 to 270 of about 347,248 (305)

Platelets express functional Toll-like receptor-4

Blood, 2005
AbstractProfound thrombocytopenia occurs in humans with sepsis and in mice administered lipopolysaccharide (LPS). Growing evidence indicates that platelets may contribute to these abnormalities, but whether that is a direct result of LPS activation of platelets or an indirect result of other inflammatory mechanisms remains unclear.
Graciela, Andonegui, Steven M, Kerfoot, Kelly, McNagny, Kirsten V J, Ebbert, Kamala D, Patel, Paul, Kubes   +5 more
openaire   +2 more sources

Role of Toll-Like Receptor 4 in Diabetic Retinopathy.

Pharmacological Research, 2021
Diabetic retinopathy (DR) is the most frequent microvascular complication of diabetes mellitus (DM) and a leading cause of blindness worldwide. Evidence has shown that DR is an inflammatory disease with hyperglycemia playing a causative role in the ...
Nikoo Bayan, Niloufar Yazdanpanah, N. Rezaei   +2 more
semanticscholar   +1 more source

Toll-like receptor 2 and Toll-like receptor 4 polymorphisms in invasive pneumococcal disease

Microbes and Infection, 2007
Toll-like receptors (TLRs) recognize distinct pathogen-associated molecular patterns and trigger anti-microbial host defense responses. Several in vitro and in vivo studies in mice indicate that TLR2 and TLR4 are involved in the defense against Streptococcus pneumoniae. Studies have revealed associations between polymorphisms in TLRs and human diseases.
Moens, L., Verhaegen, J., Pierik, M.J., Vermeire, S., de Boeck, K., Peetermans, W.E., Bossuyt, X.   +6 more
openaire   +3 more sources

Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders

Expert opinion on therapeutic targets, 2019
Introduction: Adverse immune activation contributes to many central nervous system (CNS) disorders. All main CNS cell types express toll-like receptor 4 (TLR 4).
Gunnar R Leitner, Tyler J. Wenzel, Nick Marshall, Ellen J Gates, A. Klegeris   +4 more
semanticscholar   +1 more source

Expression of Toll-like Receptor 2 and Toll-like Receptor 4 in Tuberculous Pleural Effusion

Medicinal Chemistry, 2017
Toll-like receptor-2 (TLR2) and Toll-like receptor-4 (TLR4) have been reported to play a crucial role in tuberculosis, however, little is known about their expression in tuberculous pleuritis.The goal of this work is to explore the expressions of TLR2 and TLR4 in tuberculous pleuritis and their predominant expressions on cells.Levels of soluble TLR2 ...
Yingzhong, Lin, Tingmei, Feng, Jiao, Lan, Chunxia, Chen, Zhiqiang, Qin, Yanbin, Wu, Huanzhong, Shi, Jianbo, Ye, Caizhou, Wei, Wu, Wang, Luying, Huang   +10 more
openaire   +2 more sources

Toll‐like Receptor‐2 and Toll‐like Receptor‐4 Expression on Maternal Neutrophils During Pregnancy

American Journal of Reproductive Immunology, 2010
Nitsche JF, Jiang S‐W, Brost BC. Toll‐like receptor‐2 and toll‐like receptor‐4 expression on maternal neutrophils during pregnancy. Am J Reprod Immunol 2010; 64: 427–434Problem  Toll‐like receptors (TLR) are an important part of the innate immune system and are present in a variety of human tissues.
Joshua F, Nitsche, Shi-Wen, Jiang, Brian C, Brost   +2 more
openaire   +2 more sources

Comparative fine maps of bovine toll-like receptor 4 and toll-like receptor 2 regions

Mammalian Genome, 2003
Toll-like receptors are cell-surface receptors that activate innate and adaptive immune responses. We have used a 5000-rad, whole-genome radiation hybrid panel to map Toll-like receptor 4 (TLR4) to the distal end of bovine Chromosome (Chr) 8, and Toll-like receptor 2 (TLR2) to the proximal end of bovine Chr 17.
Stephen N, White, Srinivas R, Kata, James E, Womack   +2 more
openaire   +2 more sources

Human melanocytes express functional Toll‐like receptor 4

Experimental Dermatology, 2008
AbstractBackground:  Melanocytes are not simply pigment‐producing cells, but produce substances with a range of biological functions including antimicrobial defense. Recent studies suggest that Toll‐like receptors (TLRs) play an important role in the cellular response through the recognition of pathogens.Objectives:  To investigate whether TLR4 and ...
Joo Hee, Ahn, Tae Jun, Park, Sun Hee, Jin, Hee Young, Kang   +3 more
openaire   +2 more sources

Toll-Like Receptor 4

Exercise and Sport Sciences Reviews, 2006
Evidence is emerging that exercise training has anti-inflammatory effects. Our early finding that blood cultures from trained subject had a reduced responsiveness to lipopolysaccharide led to a series of studies in which we measured toll-like receptor 4--the primary signaling receptor for lipopolysaccharide.
Michael G, Flynn, Brian K, McFarlin
openaire   +2 more sources

Toll-like receptor 4 – a multifunctional virus recognition receptor

Trends in Microbiology
Since the initial description of Toll receptors in Drosophila and their mammalian counterparts Toll-like receptors (TLRs), numerous fundamental and applied studies have explored their crucial role as sensors of pathogen-associated molecular patterns (PAMPs).
Elina Gerber-Tichet, Fabien P. Blanchet, Karim Majzoub, Eric J. Kremer   +3 more
openaire   +2 more sources