Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies
Advanced Science, EarlyView.In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang +4 more
wiley +1 more source
Upregulating miR-27a-3p inhibits cell proliferation and inflammation of rheumatoid arthritis synovial fibroblasts through targeting toll-like receptor 5. [PDF]
Exp Ther Med, 2021 Chen L, Lu Q, Chen J, Feng R, Yang C.
europepmc +1 more source
NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity
Advanced Science, EarlyView.Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li +7 more
wiley +1 more source
Exosomal microRNA-150-5p from bone marrow mesenchymal stromal cells mitigates cerebral ischemia/reperfusion injury via targeting toll-like receptor 5. [PDF]
Bioengineered, 2022 Li X, Bi T, Yang S.
europepmc +1 more source
Advanced Science, EarlyView.Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes +15 more
wiley +1 more source
Insights into structure and dynamics of extracellular domain of Toll-like receptor 5 in Cirrhinus mrigala (mrigala): A molecular dynamics simulation approach. [PDF]
PLoS One, 2021 Rout AK +8 more
europepmc +1 more source
The immunomodulatory properties of helminth-derived products on dendritic cell maturation and function [PDF]
, 2009 Parasitic worms and molecules derived from them drive Th2/Treg immune responses in mammalian hosts and have powerful anti-inflammatory properties which are shown to have therapeutic effects on inflammatory diseases.
Dowling, David J.
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