Results 251 to 260 of about 245,171 (291)

A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin [PDF]

Journal of Experimental Medicine, 2007
The molecular basis for Toll-like receptor (TLR) recognition of microbial ligands is unknown. We demonstrate that mouse and human TLR5 discriminate between different flagellins, and we use this difference to map the flagellin recognition site on TLR5 to 228 amino acids of the extracellular domain.
Kelly D Smith, Richard Bonneau, Roland K Strong   +2 more
exaly   +3 more sources

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The Effect of Denatured Flagellin on Toll-Like Receptor-5 (TLR-5) in Mice

Endocrine, Metabolic & Immune Disorders - Drug Targets, 2018
Previous studies have demonstrated that flagellin, a component of bacterial flagella, engages Toll-Like receptor 5 (TLR-5) causing the activation of the Myeloid Differentiation Factor-88 (MYD-88) pathway that leads to the production of pro-inflammatory cytokines including Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-12 (IL-12).
Soha, Mcheik, Nayla S, Al-Akl, Alexander M, Abdelnoor   +2 more
openaire   +2 more sources

Molecular cloning and functional analysis of duck Toll-like receptor 5

Research in Veterinary Science, 2014
Toll-like receptor 5 (TLR5) is responsible for the recognition of bacterial flagellin in vertebrates. In this study, we cloned the single-exon TLR5 gene of the Maya breed of Common Shelduck (Tadorna tadorna). The TLR5 open reading frame is 2580 bp in length and encodes an 859-amino acid protein.
Dan, Xiong, Zhiming, Pan, Xilong, Kang, Jing, Wang, Li, Song, Xinan, Jiao   +5 more
openaire   +2 more sources

Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin

Journal of Structural Biology, 2012
The structure of full-length human TLR5 determined by electron microscopy single-particle image reconstruction at 26Å resolution shows that TLR5 forms an asymmetric homodimer via ectodomain interactions. The structure shows that like TLR9, TLR5 dimerizes in the absence of ligand. The asymmetry of the dimer suggests that TLR5 may recognize two flagellin
Kaifeng, Zhou, Ryuta, Kanai, Phong, Lee, Hong-Wei, Wang, Yorgo, Modis   +4 more
openaire   +2 more sources

Toll-like receptors 1, 2, 4, 5, and 6 in gastric cancer

Virchows Archiv, 2023
Toll-like receptors (TLRs) are expressed on both immune cells and tumor cells, triggering both anti-tumor and pro-tumor responses. Therefore, TLRs have potential as prognostic biomarkers and immunotherapeutic targets. The aim of this study was to investigate TLR1, TLR2, TLR4, TLR5, and TLR6 expression and association with clinicopathological variables ...
Maarit Eskuri, Niko Kemi, Olli Helminen, Heikki Huhta, Joonas H Kauppila   +4 more
openaire   +2 more sources

Toll like receptor-5: protecting the gut from enteric microbes

Seminars in Immunopathology, 2007
The intestine is normally colonized by a large and diverse commensal microbiota and is occasionally exposed to a variety of potential pathogens. In recent years, there has been substantial progress made in identifying molecular mechanisms that normally serve to protect the intestine from such enteric bacteria and which may go awry in chronic idiopathic
Matam, Vijay-Kumar, Jesse D, Aitken, Andrew T, Gewirtz   +2 more
openaire   +2 more sources

Toll-Like Receptor-5 and the Innate Immune Response to Bacterial Flagellin

2002
The innate immune system identifies the presence of infection by detecting structures that are unique to microbes and that are not expressed in the host. The bacterial flagellum (Latin, a whip) confers motility, on a wide range of bacterial species. Vertebrates, plants, and invertebrates all have evolved flagellar recognition systems that are activated
K D, Smith, A, Ozinsky
openaire   +2 more sources

Molecular cloning, characterization and expression of goose Toll-like receptor 5

Molecular Immunology, 2012
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) that are vital to activation of the innate immune system in response to invading pathogens through their recognition of pathogen-associated molecular patterns (PAMPs). TLR5 is responsible for the recognition of bacterial flagellin in vertebrates. In this study, we cloned the goose TLR5
Qiang, Fang, Zhiming, Pan, Shizhong, Geng, Xilong, Kang, Jinlin, Huang, Xiaolin, Sun, Qiuchun, Li, Yinqiang, Cai, Xinan, Jiao   +8 more
openaire   +2 more sources

Toll‐like receptors ‐4 and ‐5 in oral and cutaneous squamous cell carcinomas

Journal of Oral Pathology & Medicine, 2014
BackgroundOral squamous cell carcinoma (OSCC) has a worse prognosis than cutaneous squamous cell carcinoma (CSCC). Toll‐like receptor‐ 4 (TLR‐4) and TLR‐5 are transmembrane proteins that recognize endogenous and microbial agents. Their activation has been connected to cancer invasion.ObjectiveThe aim was to study the expression of TLR‐4 and TLR‐5 in ...
Abdirisak Ahmed Haji, Omar, Johanna, Korvala, Caj, Haglund, Susanna, Virolainen, Valtteri, Häyry, Timo, Atula, Risto, Kontio, Jarmo, Rihtniemi, Antti, Pihakari, Timo, Sorsa, Jaana, Hagström, Tuula, Salo   +11 more
openaire   +2 more sources

Different genetic patterns in avian Toll-like receptor (TLR)5 genes

Molecular Biology Reports, 2011
Toll-like receptors (TLRs) mediate immune response via recognition of pathogen-associated molecular patterns (PAMPs), thus play important roles in host defense. Polymorphisms of TLR5 may affect their recognition of bacterial flagellin, leading to varied host resistance to pathogenic infections.
Wenke, Ruan, Yanhua, Wu, Shijun J, Zheng
openaire   +2 more sources