Results 101 to 110 of about 300,180 (287)

Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance [PDF]

, 2012
INTRODUCTION Endosomal toll-like receptors (TLRs) have recently emerged as potential contributors to the inflammation observed in human and rodent models of rheumatoid arthritis (RA).
Alzabin, Saba, Kong, Philip, Medghalchi, Mino, Palfreeman, Andrew, Sacre, Sandra, Williams, Richard   +5 more
core   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Toll-like receptor-mediated immune imbalance in asthma: controversies, breakthroughs, and future directions

Frontiers in Immunology
As a chronic inflammatory illness of the respiratory system, asthma occurs due to various factors and is characterized by a T helper 2 (Th2)-skewed immune response, airway hyperresponsiveness, and reversible airflow obstruction. Toll-like receptors (TLRs)
Xinyi Xu, Ruihan Yu, Zhuoqun Yang, Chenyu Li, Huabao Xiong, Chunxia Li   +5 more
doaj   +1 more source

Toll-Like Receptors, Tissue Injury, and Tumourigenesis

Mediators of Inflammation, 2010
Toll-like receptors (TLRs) belong to a class of molecules known as pattern recognition receptors, and they are part of the innate immune system, although they modulate mechanisms that impact the development of adaptive immune responses.
Savvas Ioannou, Michael Voulgarelis
doaj   +1 more source

Highly‐Conductive and Micro‐Structured Transparent Glass Substrates for Efficient and Scalable Photoelectrochemical Applications

Advanced Science, EarlyView.
This work paves the way for practical photoelectrochemical water splitting devices by addressing key upscaling challenges related to substrate conductivity, absorber inhomogeneity, and mass transfer limitations. Integrated improvements in substrate engineering, material processing, device architecture, and operational conditions allow the development ...
Telmo da Silva Lopes, Jeffrey Capitão, Amin Khan, Leonardo Rodrigues, Dzmitry Ivanou, Tânia Lopes, Paula Dias, Adélio Mendes   +7 more
wiley   +1 more source

Emerging targets in human lymphoma: targeting the MYD88 mutation [PDF]

, 2016
B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link ...
Horikawa, Keisuke, Jeelall, Yogesh S., Wang, James Q.   +2 more
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Toll-like Receptors and Inflammatory Bowel Disease

Frontiers in Immunology, 2018
Inflammatory bowel disease (IBD) is one relapsing and lifelong disease that affects millions of patients worldwide. Increasing evidence has recently highlighted immune-system dysfunction, especially toll-like receptors (TLRs)-mediated innate immune ...
Yue Lu, Xinrui Li, Shanshan Liu, Yifan Zhang, Dekai Zhang, Dekai Zhang   +5 more
doaj   +1 more source

Creating a new Ontology: a Modular Approach [PDF]

, 2010
Creating a new Ontology: a Modular ApproachComment: in Adrian Paschke, Albert Burger, Andrea Splendiani, M. Scott Marshall, Paolo Romano: Proceedings of the 3rd International Workshop on Semantic Web Applications and Tools for the Life Sciences ...
Dmitrieva, Julia, Verbeek, Fons J.
core   +2 more sources

The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release [PDF]

, 2013
<p>Objectives: Macrophages are central to the inflammatory processes driving rheumatoid arthritis (RA) synovitis. The molecular pathways that are induced in synovial macrophages and thereby promote RA disease pathology remain poorly understood.</
Ananth, Antoniv, Asquith, Asquith, Baeten, Bresnihan, Darren Lee Asquith, Enevold, Feldmann, Fontaine, Gerlag, Haringman, He, Huang, Iain B McInnes, Iwahashi, J Alastair Gracie, Jagtar Singh Nijjar, Jahangier, James H Reilly, Janowski, Kauffmann, Kinne, Koch, Long, Lucy E Ballantine, Manhal Khuder Makdasy, Mariola Kurowska-Stolarska, Mulherin, Ospelt, Pamela B Wright, Radstake, Ridley, Sabina Patel, Sack, Sacre, Sattar, Shauna Kerr, Tamaki, van der Heijden, van Halm, van Sijl, Zhao   +42 more
core   +1 more source