Results 181 to 190 of about 300,180 (287)

Systematic review of structural and immunological features of mollusk toll-like receptors in aquaculture context. [PDF]

Front Immunol
Li H, Li X, Zhu Y, Xu J, Zhao Q, Chen X, Zhang Y, Zhao L, Chen Y, Weng R, Chen K.   +10 more
europepmc   +1 more source

Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1‐mediated macrophage polarization via the PI3K/Akt pathway

Animal Models and Experimental Medicine, EarlyView.
Transcriptome sequencing identified secreted phosphoprotein 1 (SPP1) as a crucial target through which methylophiopogonanone A (MOA) ameliorates pulmonary fibrosis. Molecular docking and microscale thermophoresis (MST) assays confirmed a favorable binding affinity between MOA and SPP1.
Fan Yang, Tian Li, Weiran Jia, Dingjie Xu, Liangdan Sun, Yanlei Ge, Yiwei Shi, Hong Xu, Xudong Song, Fuyu Jin, Na Mao   +10 more
wiley   +1 more source

Toll-like Receptors in Immuno-Metabolic Regulation of Emotion and Memory. [PDF]

Cells
Crespo-Quiles C, Femenía T.
europepmc   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

Impact of toll-like receptors on food allergy: mechanisms involved and scientific evidence. [PDF]

J Physiol Biochem
Álvarez-Azcarreta S, Mountasar-Didouch W, González AM, Muniz FJS.   +3 more
europepmc   +1 more source

Complementary multi‐omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes

Animal Models and Experimental Medicine, EarlyView.
This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu, Xia Zheng, Yajun Zhang, Yinghui Fang, Yanan Zhen   +4 more
wiley   +1 more source

Increased expression of Toll-like receptors and associated alarmins in temporal arteries of patients with giant cell arteritis. [PDF]

Mol Med
Seidlberger S, Schirmer M, Wietzorrek G, Jiménez-Heffernan JA, Pardines M, de Las Fuentes Monreal M, González-Gay MA, Castañeda S, Santos-Sierra S.   +8 more
europepmc   +1 more source

A high‐fat diet with vitamin D and propylthiouracil produces a pro‐atherogenic phenotype in rats

Animal Models and Experimental Medicine, EarlyView.
Male Sprague–Dawley rats received a cholesterol‐rich high‐fat diet supplemented with vitamin D and propylthiouracil for 11 weeks. The model induced dyslipidemia (increased total cholesterol/low‐density lipoprotein, decreased triglycerides), inflammation (increased interleukin‐6 and serum amyloid A), hypercalcemia, and reduced circulating endothelial ...
Angélique Lewies, Vitaris Kodogo, Johannes Frederik Wentzel, Francis Edwin Smit   +3 more
wiley   +1 more source

Bio‐Propelled Stomatocyte Nanomotors with Glutathione‐Responsiveness for Osteoarthritis Treatment

Angewandte Chemie, EarlyView.
Glutathione (GSH)‐responsive stomatocyte nanomotors with encapsulated MTX utilize oxygen to achieve autonomous motion and undergo GSH‐induced dissociation, enhancing cellular uptake, tissue penetration, and MTX release within the osteoarthritis (OA) region, thereby improving therapeutic efficacy.
Jianhong Wang, Mengsi Zhan, Hanglong Wu, Maarten Bransen, Ioanna Balmpouzi, Xianwen Lou, Junjie Liu, Nina Wang, Zhiqiang Wang, Heiner Friedrich, Jingxin Shao, Jan C. M. van Hest, Xiangyang Shi   +12 more
wiley   +2 more sources

Gonadocorticoids Have Different Effects on the Expression of Toll-like Receptors When Infected with Various HIV-1 Subtypes. [PDF]

Viruses
Nosik M, Ryzhov K, Berezhnaya E, Bystritskaya E, Lobach O, Kiseleva I, Kostyuchenko E, Kuzina A, Meremianina E, Kireev D, Svitich O.   +10 more
europepmc   +1 more source