Results 41 to 50 of about 316,585 (246)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Optimization of Chinese Postman Problem Using Fuzzy-Based Priority Weighted Graph

Inquietud Empresarial
: In the early 1960s, Chinese mathematician Mei-Ko Kwan (M. Guan) introduced a method aimed at minimizing mail carriers’ route lengths. This method led to the exploration of various formulations of the Chinese Postman Problem (CPP), resulting in at ...
Jay Chandra Yadav, Mohammad Rizwanullah
doaj   +2 more sources

Toll-dependent and Toll-independent immune responses in Drosophila [PDF]

Journal of Endotoxin Research, 2004
The multifaceted response of the fruitfly Drosophila melanogaster to infection by a wide range of microbes is complex and remarkably efficient. Its most prominent aspect is the immune-inducible expression of a set of potent antimicrobial peptides. Genetic analysis of the regulation of the genes encoding these peptides has led to the identification of ...
Imler, Jean-Luc, Ferrandon, Dominique, Royet, Julien, Reichhart, Jean-Marc, Hetru, Charles, Hoffmann, Jules   +5 more
openaire   +4 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Psychological profiles of COVID vaccine-hesitant individuals and implications for vaccine message design strategies

Vaccine: X, 2023
COVID-19 has caused tremendous consequences in the U.S., and combating the pandemic requires a significant number of Americans to receive COVID-19 vaccines.
Yanmengqian Zhou, Ruobing Li, Lijiang Shen   +2 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Multi-Output Power Converter, Operated from a Regulated Input Bus, for the Sireus Rate Sensor

E3S Web of Conferences, 2017
This paper describes a DC to DC converter designed to meet the power supply requirements of the SiREUS Coarse Rate Sensor (CRS) which is a 3-axis MEMS Rate Sensor (MRS) that uses a resonating ring gyro and will be used in different ESA missions.
Torrecilla Marcos Compadre, Weinberg Alan H, Hutton Patrick, Clark Craig   +3 more
doaj   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Fusion of Simulation and AI Methods for Understanding HOV/HOT Lane Operational Flow Dynamics

Vehicles
This study investigated the impact of converting High Occupancy Vehicle (HOV) lanes to High Occupancy Toll (HOT) lanes on fundamental traffic flow characteristics, focusing on speed, density, and flow relationships.
Deo Chimba, Therezia Matongo, Hellen Shita, Erickson Senkondo, Masanja Madalo, Afia Yeboah   +5 more
doaj   +1 more source