Results 71 to 80 of about 8,134 (194)

Potential amelioration of liver function by low-dose tolvaptan in heart failure patients

Toxicology Reports
Aim: This study aimed to evaluate the relationships between the pharmacokinetics of tolvaptan and its metabolites (DM-4103 and DM-4107) and liver injury in heart failure patients, using relevant laboratory test values and markers of hepatocyte injury and
Yasuaki Mino, Kohei Hoshikawa, Takafumi Naito, Shunta Akutsu, Yumi Imoto, Emi Nakatsugawa, Masao Saotome, Yuichiro Maekawa, Junichi Kawakami   +8 more
doaj   +1 more source

Effectiveness and safety of combining thiazides with loop diuretics vs. loop diuretics monotherapy in patients with acute decompensated heart failure: A retrospective cohort study

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 220-229, January 2026.
Aims This study investigated factors associated with and outcomes of combined loop diuretics with hydrochlorothiazide (HCTZ) for acute decompensated heart failure (ADHF). Methods In this retrospective study, adults hospitalized for ADHF and who received intravenous loop diuretics between January 2016 and March 2023 were enrolled.
Chia‐Chen Hsu, Hsien‐Chih Chiu, Ju‐Chieh Wung, Yueh‐Ching Chou, Yuh‐Lih Chang, Chian‐Ying Chou, Chin‐Chou Huang   +6 more
wiley   +1 more source

Renal ultrasonography predicts worsening renal function in patients with heart failure under tolvaptan administration

ESC Heart Failure
Aims Renal dysfunction in patients with chronic heart failure predicts a poor prognosis. Tolvaptan has a diuretic effect in patients with chronic kidney disease and heart failure without adverse effects on renal function.
Nobukiyo Tanaka, Yoshio Furukawa, Takuya Maeda, Hiroki Ishihara, Kazuhiro Dan, Masanori Teramura, Kei Ichihashi, Tetsuro Takase, Yuya Takahashi, Daichi Tsuzura, Akira Shinoda, Masato Fujii, Hisashi Okada, Fumiharu Itabashi, Tomohiko Teramoto   +14 more
doaj   +1 more source

Fármacos que atuam modulando a ação da vasopressina [PDF]

, 2015
Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências FarmacêuticasA vasopressina, também é designada por hormona antidiurética (ADH), a nível renal aumenta a
Cardoso, Ana Catarina Santos
core  

Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
The management of cancer and tissue regeneration remains a substantial challenge to global health. Organoids, which are stem cell‐derived three‐dimensional multicellular structures, are revolutionizing biomedical research. Therefore, this review highlights their applications in cancer research and regenerative medicine, while discussing current ...
Ruiyang Li, Yuezhou Wu, Zhu'anzhen Zheng, Fengjin Zhou, Ke Xu, Jiacan Su   +5 more
wiley   +1 more source

Miscellanea. Folyóirat-referátumok. Beszámoló. OH-KVÍZ [PDF]

, 2016
Folyóirat-referátumok.Diabetológia Egészséges fiataloknál a terhelés alatti maximális zsírégetés kapcsolatban van a 24 órás zsírégetéssel és az inzulinérzékenységgel (Maximal fat oxidation during exercise is positively associated with 24 ...
Apor, Péter, Fischer, Tamás, Gáspárdy, Géza, Jakobovits, Antal, Nagy, László Béla, Schmidt, Péter   +5 more
core   +1 more source

Diagnosis and management of hyponatraemia: AGREEing the guidelines [PDF]

, 2015
Hyponatraemia is a common electrolyte disorder associated with significant complications and controversies regarding its optimal management. Clinical practice guidelines and consensus statements have attempted to provide clinicians with evidence-based ...
Maxwell, Alexander P
core   +1 more source

REDUCE-IT USA: Results From the 3146 Patients Randomized in the United States. [PDF]

, 2020
BackgroundSome trials have found that patients from the United States derive less benefit than patients enrolled outside the United States. This prespecified REDUCE-IT (Reduction of Cardiovascular Events with Icosapent Ethyl - Intervention Trial ...
Ballantyne, Christie M, Bhatt, Deepak L, Brinton, Eliot A, Budoff, Matthew J, Chung, Mina K, Doyle, Ralph T, Gibson, C Michael, Giugliano, Robert P, Granowitz, Craig, Jacobson, Terry A, Jiao, Lixia, Juliano, Rebecca A, Ketchum, Steven B, Miller, Michael, Olshansky, Brian, REDUCE-IT Investigators, Steg, Ph Gabriel, Tardif, Jean-Claude   +17 more
core   +1 more source

Severe Hyponatremia in the Emergency Department Incidence of Cerebral Edema and Risk of Osmotic Demyelination Syndrome

Academic Emergency Medicine, Volume 33, Issue 1, January 2026.
ABSTRACT Study Objective Treatment strategies in severe hyponatremia aim at rapid sodium correction to prevent or treat cerebral edema but limit sodium rise to prevent osmotic demyelination syndrome (ODS). The true risk of edema or ODS in ED patients is unknown.
Volker Burst, Ramon Rabii, Julian Peto‐Madew, Thorsten Persigehl, Stefan Haneder, Matthias Johannes Hackl, Christoph Hüser, Moritz Trappe, Sadrija Cukoski, Kathrin Möllenhoff, Victor Suárez   +10 more
wiley   +1 more source

Tolvaptan for Primary Aldosteronism and Autosomal Dominant Polycystic Kidney Disease: A Case Report

Case Reports in Nephrology and Dialysis, 2018
A 59-year-old Japanese woman was admitted for evaluation of muscle weakness. Autosomal dominant polycystic kidney disease had been diagnosed at the age of 47 years, followed by primary aldosteronism at 53 years.
Kyohei Kunizawa, Junichi Hoshino, Hiroki Mizuno, Tatsuya Suwabe, Keiichi Sumida, Masahiro Kawada, Masayuki Yamanouchi, Akinari Sekine, Noriko Hayami, Rikako Hiramatsu, Eiko Hasegawa, Naoki Sawa, Kenmei Takaichi, Shigeru Shibata, Yoshifumi Ubara   +14 more
doaj   +1 more source