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Natural Products as Novel Therapeutic Agents for Triple-Negative Breast Cancer: Current Evidence, Mechanisms, Challenges, and Opportunities. [PDF]

Molecules
Li Q, Ye Z, Wang G, Chen Y, Deng J, Wang D, Wang Y.   +6 more
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Toosendanin relatives, trypanocidal principles from Meliae Cortex

Journal of Natural Medicines, 2020
Africa Trypanosomiasis remains a serious health problem, but the approved drugs for this disease are so few that novel trypanocidal compounds are demanded. In search for trypanocidal principles from medicinal plants, we found MeOH extracts of Meliae Cortex with potent activity through the screening from about 300 kinds of methanolic extract.
Michel N. Mifundu, Nobutoshi Murakami, Tomikazu Kawano, Satoru Tamura   +3 more
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Toosendanin induced hepatotoxicity via triggering PERK-eIF2α-ATF4 mediated ferroptosis

Toxicology Letters, 2023
Toosendanin (TSN) is the main active compound of Melia toosendan Sieb et Zucc with various bioactivities. In this study, we investigated the role of ferroptosis in TSN-induced hepatotoxicity. The characteristic indicators of ferroptosis were detected including reactive oxygen species (ROS), lipid-ROS, glutathione (GSH), ferrous ion and the expression ...
Yonghong, Liang, Sixin, Chen, Suqin, Han, Li, Luo, Feihai, Shen, Zhiying, Huang   +5 more
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Development of an enzyme-linked immunosorbent assay for toosendanin

Analytica Chimica Acta, 2008
Enzyme-linked immunosorbent assays (ELISAs) were developed by using polyclonal antibody for toosendanin (TSN), a biopesticide from Melai toosendan Sieb. et Zucc. Their application in the determination of this analyte in spiked cabbage, tomato and apple samples was studied.
Jing, Zhang, Gang, Feng, Li, Luo, Xiang Yang, Yu, Zhi Qing, Ma, Jun Tao, Feng, Xian Jin, Liu, Xing, Zhang   +7 more
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Toosendanin triggered hepatotoxicity in zebrafish via inflammation, autophagy, and apoptosis pathways

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2021
Toosendanin (TSN) is a crucial component from Toosendan Fructus with a promising anti-tumor capacity. It is also the primary suspect hepatotoxic component of Toosendan Fructus. However, the mechanisms underlying TSN-induced liver injury are still largely unknown.
Meng, Sun, Qing, Liu, Qiuxia, Liang, Shuo, Gao, Kaiyan, Zhuang, Yun, Zhang, Huazheng, Zhang, Kechun, Liu, Gaimei, She, Qing, Xia   +9 more
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Toosendanin Reprograms Macrophages to Enhance Antitumor Immunity

Cancer Discovery, 2023
Abstract Toosendanin (TSN) converts macrophages from immunosuppressive to immunostimulatory in glioblastoma.
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Evaluation of toosendanin as a botulinum neurotoxin antagonist

The Botulinum J., 2008
Toosendanin (TSN), a tetranortriterpenoid compound from the plant Melia toosendan, has been reported to protect rats and non-human primates from the lethal actions of botulinum neurotoxin A (BoNT/A). TSN was tested in isolated mouse phrenic nerve-hemidiaphragm preparations against BoNT serotypes A, B and E.
Michael Adler, James D. Nicholson
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Design, synthesis, and anti-triple negative breast cancer activity of novel Toosendanin derivatives

Bioorganic & Medicinal Chemistry Letters, 2023
Toosendanin (TSN) is a natural anti-cancer compound that is isolated from the traditional Chinese herbal Melia toosendan Sieb et Zucc. However, the research effect of TSN in the treatment of Triple negative breast cancer (TNBC) is still far from ideal.
Honglin Zhang, Yiyan Chen, Qiuyu Liu, Wen-Wen Xiao, Li-Dong Shao, Zheng-Hong Pan, Chuan-Huizi Chen, Dashan Li   +7 more
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Anti-cancer effect of toosendanin and its underlying mechanisms

Journal of Asian Natural Products Research, 2018
Toosendanin (TSN) is a triterpenoid purified from the medicinal herb Melia toosendan Sieb. et Zucc and has been used as an insecticide for decades. Recent studies have attracted increasing interest of TSN due to its novel anti-cancer effect in diverse cancer models.
Sha, Zhang, Liang, Cao, Zong-Ren, Wang, Zhe, Li, Jing, Ma   +4 more
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Toosendanin facilitates [³H]noradrenaline release from rat hippocampal slices

Natural Toxins, 1996
AbstractSlices of hippocampus of the rat, preincubated with [3H]noradrenaline ([3H]NA), were used to investigate the effects of toosendanin on the release of [3H]NA. Toosendanin potently enhanced spontaneous 3H outflow. Seventy‐four percent of the enhancement was inhibited by reserpine pretreatment.
H, Hua-Yu, Z, Cheng-Wen, S, Yu-Liang
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